Synthetic Regeneration Laboratory at Columbia
@SynRegLab
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#SyntheticRegeneration & Systems Physiology Laboratory @Columbia | Engineering Tissue Healing through Systems Physiology
Manhattan, NY
Joined April 2022
CRISPR screens revolutionized genetics; but what if the method itself introduces noise? 🤔 📣We developed RESTRICT-seq, a next-gen screening method to address this📣. #PrecisionGenomics
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People say, “you become the average of your five closest friends.” But in tissues, a perturbed cell does NOT simply become the average of its nearest neighbors. Sometimes a cell breaks from the crowd. Sometimes signals travel far. Sometimes niches overpower proximity. That is
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🗨️ Just published in @NatureBiotech: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper link and annotated walkthrough in the thread below (1/11)
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For readers interested in therapies that harness regulatory T cells to treat disease, here's a review on this topic https://t.co/5BCUo8O9RN
https://t.co/4CVfcN5qcT and a review discussing their potential to reset the immune system https://t.co/TdFxd8wjli
https://t.co/oYPCyIOa8c
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CZI pivots, going "all in" on AI models of the cell and now whole physiological systems..starting with the virtual immune system.
apnews.com
For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — “to cure, prevent or manage all disease” — if not in their lifetime,...
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I'm thrilled to deliver the @ColumbiaBME "Growing Up in Science" lecture this semester and share the journey behind the data!
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Our spatio-temporal map of lesion repair in the heart at single-cell resolution is now published in @NatureCVR. https://t.co/90dWoRfL9i We dissected dynamics of multicellular niches that control cardiac repair. See 🧵for highlights.
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Squidiff: Predicting cellular development and responses to perturbations using a diffusion model https://t.co/Us2v0OebqQ
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A guide on how to select the appropriate statistical test based on the type of research question and data. https://t.co/N3uWOD2gla
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This week's @Nature cover highlights a report of A.I. mediated distortion When #ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants https://t.co/qTSHdxF8Ia
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A wonderful afternoon well spent learning frm Simon van deursen @DrWoappi lab abt their elegant work with visium on skin wounding n their analysis pipelines and Aleks Janjic @10xGenomics 4 practical guidelines. Thank you attendees for making it an interactive successful event!
Join @SynRegLab @10Xgenomics to learn @Drwoappi work on spatial morpho-transcriptomics. Register https://t.co/Uj4BlP2otv.
@Cancer_dynamics @ColumbiaMed @ZuckermanBrain @columbiacancer @columbia @CUMCNeurology @TaubInstitute @CSCIColumbia @ColumbiaSysBio
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Systemic immune activity occurs during human immune system maturation @CellCellPress
https://t.co/0iQXq2jUXX 🇨🇳
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Pre-print alert! And this one really is a must read for anyone that does spectral flow cytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? https://t.co/BG3DVIM13r
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Parity and breastfeeding reduce the risk of breast cancer via accumulation of resident memory CD8 T cells in breast tissue @Nature @LoiSher @LMackayLab
@PeterMacCC @UniMelb @BalajiVirassamy @pssavas
https://t.co/EeOabttNsr 🇦🇺
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Join @SynRegLab @10Xgenomics to learn @Drwoappi work on spatial morpho-transcriptomics. Register https://t.co/Uj4BlP2otv.
@Cancer_dynamics @ColumbiaMed @ZuckermanBrain @columbiacancer @columbia @CUMCNeurology @TaubInstitute @CSCIColumbia @ColumbiaSysBio
docs.google.com
In this session, we will have two presenters. Simon Van Deursen from Dr. Yvon Woappi’s group from Columbia University will present their research on immunodynamics that utilizes Visium HD assay and...
Spatial biology has transformed our understanding of physiology and disease. Our team @SynRegLab recently developed a comprehensive framework for spatial morpho-transcriptomics. We're excited to partner with @10xGenomics to make this knowledge more widely available!
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Spatial biology has transformed our understanding of physiology and disease. Our team @SynRegLab recently developed a comprehensive framework for spatial morpho-transcriptomics. We're excited to partner with @10xGenomics to make this knowledge more widely available!
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Indoor Rewilding of Laboratory Mice Recalibrates Pulmonary Mucosal Immunity and Mechanics https://t.co/H8jxd1FEw3
#biorxiv_immuno
biorxiv.org
Laboratory mice raised under specific-pathogen-free (SPF) conditions experience restricted microbial and antigenic exposure, which favours an immature immune system and limits their translational...
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🤔How do you design a promoter for stable titration of expression? 💡Try programmable promoter editing with DIAL! 📰Now published at @NatureBiotech 🧵 [1/n] 🔗 below
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γδ T cells are a unique population of immune cells that can recognize and kill tumors. A 2024 #ScienceReview explores current research efforts focused on how γδ cells naturally discriminate cancers from healthy tissues. https://t.co/VmJfWd95Um
#ScienceMagArchives
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So proud and excited about this the next generation of engineers and scientists! Their creativity, drive, and vision give me much optimism for the future of science. It was such a joy to return @MIT and experience it firsthand as a program Alum.
My @MIT journey began when I was nominated as a MIT Rising Star in Biomedical Sciences; an honor that transformed my academic path. I’m honored to return this year to co-lead and mentor the next generation of rising leaders and engineers. Mens et Manus! https://t.co/pZybOcZCYA
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A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice @CincyResearch @LeeGrimesLab @KyleFerchen @nsalomonis
https://t.co/EboiRPTOEm
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