Implications for Hematopoietic Models Contrary to the idea of a smooth continuum, the findings support a hierarchical model where stable, discrete progenitor states serve as key regulatory nodes. These states are governed by specific gene regulatory architectures, providing

Validation of Hierarchical Lineage Restriction Functional assays, including single-cell lineage tracing, confirmed that MultiLin progenitors can give rise to diverse mature lineages, including erythroid, myeloid, eosinophil, basophil, and mast cells. Notably, these states respond

Gene Regulatory Networks Underpinning Cell States By analyzing TF activity at base-pair resolution within open chromatin regions, we reconstructed hierarchical GRNs. These networks reveal how specific TFs such as GATA, PU.1, and IRF8 drive lineage restriction (multipotent to

Identification of Lin−CD117+Sca−CD27+ MultiLin We discovered and isolated rare bone marrow cell populations termed "MultiLin" characterized by specific surface markers that possess multilineage potential. These cells are distinct from previously categorized MPP and act as

Integration of Multimodal Data @KyleFerchen figured out how to integrate CITE-seq, TEA-seq and InfinityFlow to link cell surface markers, gene expression, and chromatin accessibility to underlying gene regulatory networks (GRNs). The clusters, gene expression and GRN edges are

What is new? Traditionally, hematopoiesis has been understood through flow cytometry, which sorts cells based on surface protein markers, forming a hierarchical model of progenitor states. However, this approach struggles to capture the full heterogeneity and transitional

New “discrete state” model of hematopoiesis published in Nature Immunology. https://t.co/E1bSt1cGN7 We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes. With @nsalomonis @morris_lab @BioLegend @CytekBio @NIH @NIDDKgov and

ISEH in Kumamoto

NEWS …record number of abstracts submitted for ASH2025 meeting in Orlando. See you there! @ASH_hematology

RIP David Baltimore. Here he is in our living room with Anjana Rao as the hand model for the Pappy Van Winkel we let him try. He really liked his visit, and we enjoyed having him over.

Excited to share our latest work @Nature! We show that the total number of hematopoietic stem cells (HSCs) in the body is restricted, challenging the classical model that HSC numbers are determined locally by the niche and introducing a new paradigm. (1/9) https://t.co/kvFqNQ8Nxb

With potential NIH budget cuts and funding freezes putting vital work at risk, the ASH Bridge Grant is helping researchers, and their discoveries stay on track to improve patient care. #Fight4Hematology

This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! 🎉 https://t.co/Ld9o1jedbK #ASHAwards

Hot off the press in@ImmunityCP! 🔥 Proud to share our new perspective — a collaborative effort with fantastic colleagues — proposing a unified framework to classify neutrophil subpopulations. #ThePowerOfMany 👉 https://t.co/cSK5cHssDM

.@RepGregLandsman @SenJonHusted @berniemoreno I am writing to thank Congress for the support for medical research. Please continue making medical research a priority by providing robust & sustained funding for the NIH in fiscal year 26 and beyond.

I am very excited to share our publication, out now in Nature, detailing our developed CRAFTseq methodology for capturing and analysing single cell genomic DNA amplicons alongside the transcriptome and cell surface protein expression. https://t.co/rQRubsK58P

We are excited to announce that The Myeloid Workshop is back on under ASH this year and will be held on Friday, Dec 5, from 3-7PM. ...👇

Are you concerned about how to get your trainees to ASH2025 in Orlando? Massive increase in trainee travel awards for those giving poster or oral presentations. Submit those abstracts and find out! @ASH_hematology

ASH Seeks Fundamental Discovery Science Abstracts for #ASH25 IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25. Its an experiment! Submit your cool basic science before August 5, 2025, at 11:59 p.m.

If you would like to see more fundamental basic science at ASH2025, then you will need to step up and submit abstracts. We are doing an experiment! Details soon.