❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more! https://t.co/662FGTDaEu

Research | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium. https://t.co/OWmJy0kEms https://t.co/yB43PHzssb

Research | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function. https://t.co/QXrJjsrDgJ https://t.co/ZnCxTIv59M

Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish. https://t.co/my7HOu5kSz https://t.co/fXu3iOpCmV

Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes. @DelbridgeLab https://t.co/ciUNzuYnbs https://t.co/Ixp6ISZwsf

Our chief editor, @Vesna_Tod and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work

Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy. @Ikeda_M_Cardiol https://t.co/hL11cGrSUu

❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more! https://t.co/6EaaAbYO63

Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation. https://t.co/zJeaFuD8wc https://t.co/ALuytTx1D3

Ding, Y., Chen, J., Liu, S. et al show that tetraspanin regulates the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport to balance Cdc42 and RhoA activities and influence vascular inflammation. https://t.co/2Kc48Wn60F

Research | Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts. https://t.co/ZmpWiGPO7L

Research| Chou et al. demonstrate that activation of the thrombin receptor PAR1 in the lung lymphatic vasculature augments lung lymphatic drainage in models of lung injury. https://t.co/9kUoLi5U5h https://t.co/veKTEqQYIE

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more! https://t.co/CoI95HqoyL

Research | Yang et al draw evidence from population-based and sibling cohort studies to reveal that women suffering from premenstrual disorders are at an increased risk of cardiovascular disease. https://t.co/N8zLAJqzdo https://t.co/2ULuwGH1Ni

Research | Jafari and colleagues reveal disease severity–linked right ventricle remodelling in pulmonary hypertension and identify key molecules, unveiling mechanisms of right ventricle recovery after pulmonary endarterectomy. https://t.co/eKkgSqWwHZ https://t.co/IV8MONLZb7

Research | Li, Lu et al. Demonstrate that O-GlcNAcylation enhances angiogenic transdifferentiation from fibroblasts to endothelial cells through a HIRE-dependent H3.3 deposition mechanism and facilitates vascular regeneration. https://t.co/bT9oBfj6Fw https://t.co/AoWgcVPPtq

Research | Lai et al. present the machine learning model MAARS to predict arrhythmic sudden cardiac death from multimodal imaging and clinical data in patients with hypertrophic cardiomyopathy. https://t.co/gaxSdu7IlB https://t.co/5Bb6l9f5d5

Research | Pocock et al. reveal that transient activation of 5’ AMP-activated protein kinase and oestrogen-related receptor drives robust maturation of human cardiac organoids, enabling the modelling of desmoplakin cardiomyopathy. https://t.co/i7xJyX4wet https://t.co/mH1O1ildbO

Research | Pampols-Perez et al. identify the mechanosensitive ion channel PIEZO2 as a marker for embryonic coronary artery endothelial cells and a regulator of coronary vascular remodelling and morphogenesis. https://t.co/BbYchfiKGQ https://t.co/5kjDNgoqDU

Research| Das et al. show that the correct editing activity of the methionyl tRNA synthetase, regulated by AIMP3, is required to prevent the accumulation of homocysteine and resulting cardiomyocyte death and cardiac dysfunction. https://t.co/JSgs3DX6rG https://t.co/nxoAerpJcw