Max Prigozhin
@MaxPrigozhin
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Multicolor electron microscopy, time-resolved cryo-vitrification, single-molecule biology @Harvard MCB @MCB_Harvard and Applied Physics @hseas
Cambridge, MA
Joined July 2019
New pre-print! SMLM can detect intermolecular interactions, but how? We describe an algorithm that treats intermolecular interactions probabilistically to determine the absolute number of interacting molecules: https://t.co/CCMgmu4dLF Congrats Xingchi, Polly, Arvind and Sohaib!
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A New Window into Protein Interactions at the Nanoscale @MaxPrigozhin @sohaib_ar @PNASNews @hseas @JeremyBConway @HarvardGSAS @RachelleGaudet @Harvard
https://t.co/zkCW5h1DHr
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We have an openning for a postdoctoral fellow interested in pursuing method development in cryo-vitrification (cryo-plunging and high-pressure freezing) for applications in studying nanoscale cellular organization using super-res imaging and cryo-ET. DM or e-mail me. Plz RT! 🔬🧊
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I’m super excited about the visit of my role model, Pietro! Not only have his contributions advanced our understanding of neuronal membrane biology, but he is also a wonderful mentor. His guidance has shaped the mentor I aspire to be for my trainees. 😊@PDClab @YaleCellBio
Pietro de Camilli to Present 2024 Konrad Bloch Lecture on April 1 @RachelleGaudet @VMurthyLab @PDClab @YaleMed @Harvard
https://t.co/4xHchKIteC
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Inaugural Alma Dal Co @Alma_DalCo lecture delivered today by Uri Alon. This is the first time I saw a seminar speaker give a chalk talk. It actually worked pretty well. Would you try it?
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It cannot be done, they said.. It's too flexible, they said.. 😁 https://t.co/6wDKmXeXfL
#NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf
biorxiv.org
The nuclear pore complex (NPC) is the sole mediator of nucle-ocytoplasmic transport. Despite great advances in understanding its conserved core architecture, the peripheral regions can exhibit...
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Great talk today at @MCB_Harvard by Elçin Ünal from @berkeleyMCB about aging and rejuvenation of gametes in meiosis. The slide on the photo highlights the efforts of Elçin's former PhD student @JGoody1120, who was an UG student working with me at @ChemistryUIUC. Small world 🙂
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We updated our database of POSTDOC fellowships. We identified 316 different fellowships. For each entry, we provide a link to the funder, amount, deadline, and eligibility criteria. Download this free database here: https://t.co/AhCXXsv9kg
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New and improved way to generate difference maps, from my neighbors in the @HekstraLab ! Give it a try. :)
How a "Spot the Difference" Technique Illuminates the Wiggling of Proteins @HekstraLab @doeke_hekstra @JackGreisman @brooks_den29 @mklureza @Harvard @HarvardGSAS @PNASNews @UChicago
https://t.co/EezmkoHfaI
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Interdisciplinary and Inter-Institutional Partnership Studying Neurodegenerative Diseases Wins Support from Chan Zuckerberg Initiative @JeeyunC @czi @cziscience @Harvard @synapsepark @RachelleGaudet
https://t.co/8GJ0wJItlS
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Thrilled to join the CZI neuroscience community together with @synapsepark ! Grateful for the support from @ChanZuckerberg for our team efforts to uncover the roles of brain lipid droplets!
We’re excited to support 64 interdisciplinary teams that are taking innovative approaches to study fundamental #neuroscience + neurodegenerative diseases. Read more about our second cycle of @ChanZuckerberg’s Neuroscience Collaborative Pairs Pilot Projects
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Excited to give my talk about cathodophores for multicolor EM in 1 hr! Not sure who "Xiaowen Zhuang" is but they seem to be doing cool work... 🤷♂️
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Very exciting to be at the BPS @BiophysicalSoc meeting is Philadelphia! The talks yesterday were wonderful. Looking forward to today!
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The authors “advocate for the value of learning and surprise, and for an irreverence for boundaries of all kind — between disciplines, science and technology” This was the Bell Labs culture and became the guiding light for my own research!
nature.com
Nature Reviews Physics - Venkatesh Narayanamurti and Jeffrey Y. Tsao discuss lessons learned from the success of the great 20th-century industrial research labs and warn against three common...
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Looking forward to @BiophysicalSoc BPS2024 meeting in 1 month!
Check out who have been chosen as Symp Select Speakers for the upcoming @BiophysicalSoc meeting in Philadelphia! https://t.co/Hcj25FIyYk
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Happy holidays and a good resolution for 2024 🔬😀!
"It's not a goal that is the goal, it's actually the path towards the goal." 2014 chemistry laureate Stefan Hell shares his best career advice for young scientists and researchers. #NobelPrize
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A #GPCR milestone from @m_madan_babu & @fmheydenreich, with Kobilka @stanford @Michel_Bouvier. Integrating pharmacological and structural data on beta2AR reveals the allosteric network that translates and decodes adrenaline binding into signaling response. https://t.co/MTas25IJ04
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Thrilled to see Mantis🦐🔬 💻, our new platform for high-throughput imaging and analysis of cell dynamics, in the wild. I am proud of and thankful to the team @czbiohub and @BoHuangLab 🙌.
Introducing Mantis, a two-in-one microscope designed at #CZBiohubSF that enables rapid high-dimensional imaging of molecular dynamics in the context of cell morphology. 🧵1/7 Preprint: ⬇️ https://t.co/m4NAOkml9Q
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This is a pretty cool idea for signal amplification in fluorescence imaging: first fuse the target protein with a biotin ligase, then label with a fluorescent streptavidin:
Beyond BioID: Streptavidin outcompetes antibody fluorescence signals in protein localization and readily visualises targets evading immunofluorescence detection. https://t.co/Ww5l35mHfH
#bioRxiv
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So stoked to be sharing this! New proteomics map of human subcellular architecture. CRISPR + organelle IP mass spec at scale. Check out pre-print https://t.co/OLlf1LYyud and https://t.co/Gb1TvlKcCH. 🙌 to fantastic team @czbiohub SF & collabs! 1/2
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