De Camilli Lab
@PDClab
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Laboratory of Pietro De Camilli - Department of Neuroscience at Yale University
New Haven, CT
Joined December 2018
Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM
biorxiv.org
Recent studies have identified a family of rod-shaped proteins which includes VPS13 and ATG2 and are thought to mediate unidirectional lipid transport at intracellular membrane contacts by a bridge...
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A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell–cell contacts
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Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles
biorxiv.org
Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV) membranes, their role remains elusive...
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Our new preprint reveals that the interaction of the bridge-like lipid transport protein VPS13A with the lipid scramblase XK at ER-plasma membrane contacts in K562 cells correlates with erythroid differentiation @ChaseAmos15 @YaleCellBio @YaleNeuro
biorxiv.org
Mutations of the bridge-like lipid transport protein VPS13A and of the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS) respectively, two similar conditions...
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Our review on RBG motif bridge-like #lipid transport proteins of the VPS13-ATG2 family is now out in Annual Reviews of Cellular and Development Biology @AnnualReviews @YaleCellBio
annualreviews.org
The life of eukaryotic cells requires the transport of lipids between membranes, which are separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the secretory and...
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Our collaborative study with the Cao lab at Duke-NUS reporting the synergistic pathological defects of mutations in synaptojanin 1 (Synj1) and auxilin (DNAJC6), two Parkinsonism genes, is now published.
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Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
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Our paper demonstrating the segregation of synaptic vesicle proteins from ATG9 when expressed in fibroblastic cells, and their properties to be clustered in different condensates by synapsin, is now out in Nature Communications @YaleCellBio @YaleNeuro
https://t.co/g1plo7OnpR
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And finally on Tuesday, Michael Hanna’s @lifecerealmikey poster (P2715; B327) on lipid channeling proteins that control endocytic traffic and then his talk at the minisymposium on Membrane trafficking and Organelle Homeostasis at 430pm in room 146B.
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On Tuesday, check out posters from Mick Park @Sophistarete about axonal transport and synapse formation (P2789; B403) and Daehun Park @eoqkr159 (P2807; B421) about synaptic vesicle phases,
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On Monday, go hear Shujun Cai @Cai_cryoET present her work on the In situ architecture of VPS13C at the microsymposium on Organelle Structure at 11:30am in Room 201 and then go discuss at her poster (P2107; B431) right after!
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On Sunday, check out the poster of Xinbo Wang @XinboWang8 (P1351; B361) about membrane remodeling properties of LRRK2.
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Our review for Cold Spring Harbor Perspectives in Biology on the role of lipid transport proteins at ER-contacts sites in neurodegenerative disease is now on line.
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Check out our lab's newest work from @HaniehFalahati! Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines @YaleNeuro @YaleCellBio
pnas.org
The spine apparatus is a specialized compartment of the neuronal smooth endoplasmic reticulum (ER) located in a subset of dendritic spines. It cons...
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Our paper describing VPS13A interaction with XK at ER-PM contact sites is now out on PNAS: https://t.co/xzMms7cKRy
@AGuillenSaman @YaleCellBio @YaleNeuro @KavliAtYale
pnas.org
Chorea-acanthocytosis (ChAc) and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectivel...
A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane https://t.co/qradY1keOg
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Membrane remodeling properties of the Parkinson’s disease protein LRRK2 https://t.co/uYfAcPJXYT
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