Bo Huang Lab
@BoHuangLab
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Watching the inner life of a cell
San Francisco, CA
Joined July 2019
HybriSeq: our venture into single-cell RNA profiling by combing in situ hybridization and single-cell sequencing.
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CELL-E 2 is ready to transform protein sequences to images as well as generate sequences from images.
bohuanglab.github.io
CELL-E 2 is a bidirectional transformer that generates realistic images and sequences of protein localization in the cell.
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Endogenous tagging for structural biology
pnas.org
The ability to produce folded and functional proteins is a necessity for structural biology and many other biological sciences. This task is partic...
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Here is our first step towards predicting cellular activities of proteins from their amino-acid sequences using deep-learning:
biorxiv.org
Predicting the cellular activities of proteins from their primary amino acid sequences is a highly desirable capability that could greatly enhance our functional understanding of the proteome. Here,...
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The OpenCell is now open!
A tribute to team science! @labs_mann @czbiohub @kchev @ADBxMPIB @preethiragh @loicaroyer @marcoyannic @mattersOfLight @JswLab @BoHuangLab @liilii_tweet @heracanaj @yeaarachelll + many other authors. So much fun to work with you all.
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RT @JCellBiol: LR-ExSIM and LR-ExSTORM reveal subcellular protein organization. @XiaoyuShi2, Qi Li and colleagues report the development of….
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LR-ExM and eSPIM also helped resolving endosome structures and dynamics in zebrafish embryo.
We are so happy to help Su Guo lab at UCSF use our new method LR-ExM to visualize Par-3 assisted polarized endosome dynamics in zebrafish. @BoHuangLab, @IanSeiple .
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Thanks to @ReiterLab's cool work. LR-ExM is already helping discoveries in centrosome/ciliary structures.
Dhivya Kumar @dhivkmr, @ReiterLab and colleagues identify a multi-protein complex called DISCO (DIStal centriole COmplex) that is essential for the initiation of cilium assembly. #cilia #centriole #centrosome #cellbiology #biochemistry #cytoskeleton
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Expansion microscopy gets help fron new anchors.
.@XiaoyuShi2, Li, @IanSeiple @BoHuangLab et al. report the development of label-retention expansion #microscopy w/ a set of trifunctional anchors that not only prevent fluorescent signal loss but also enable high-efficiency labeling using SNAP & CLIP tags.
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Tagging and purification of endogenous proteins for single particle cryo-EM. Nice collaboration with @yifan_ucsf !
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Just coming out in @CellCellPress: Our incredible collaboration with the .@BivonaLabUCSF and @TulpuleLab shows how cytoplasmic protein granules formed by a variety of oncogenic kinase fusion mutants can activate RAS/MAPK signaling.
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RT @LeonettiManuel: Endogenous tagging + 3D live-cell imaging + mass-spec interactome = an open-source map of the….
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Transfer learning solves the challenge of training data collection for supervised learning and also improves the performance of self-supervised learning. For image denoising, see bioRxiv and GitHub
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Here is a truly versatile and modular system for split enzymes, as demonstrated for split HaloTag:
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Still more to be done, but here is the 3rd-gen of green-colored split fluorescent protein for protein tagging and signal amplification
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RT @LeonettiManuel: @jeff_hussmann It takes a village: great collaboration between @czbiohub @JswLab @BoHuangLab Barbara Panning @LiGanLab….
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The bright gets brighter: Split red fluorescent proteins for the visualization of endogenous proteins and synapses
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Cytoplasmic protein granules organize kinase-mediated RAS signaling in cancer - our collaboration with Trever Bivona lab:
biorxiv.org
Understanding how cells spatially organize signaling events is important in normal biology and pathological conditions such as cancer. Here, we uncover a membraneless, protein granule-based subcell...
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LR-ExM using tri-functional anchors enhances #expansionmicroscopy labeling efficiency to resolve molecular-scale features in cells. Work by @XiaoyuShi2 in collaboration with @IanSeiple lab.
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