Structural Biology at St. Jude Children's Hospital
@StJudeStructBio
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Dept. of Structural Biology, St. Jude Children's Research Hospital @StjudeResearch
Memphis, TN
Joined August 2019
Our goal is to understand life and disease at atomic detail. We use #cryoEM, #NMR spectroscopy, #Xray #crystallography, #SingleMolecule spectroscopy, #MassSpectrometry and #computational tools to determine the mechanisms underpinning biological function.
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Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress. Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: . Explore this amazing resource here: .
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Beautiful work from @JunminPengLab, presenting comprehensive proteomics and phosphoproteomics data from 5 different mouse models for Alzheimer’s disease at different ages, with comparison to human data and many insights, out in @NatureComms .Congrats @YarbroJay & all coauthors!.
Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:@JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers.
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Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess.
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RT @StJudeResearch: As 2024 ends, we’re celebrating key discoveries by St. Jude scientists. In this #ResearchWrapUp, we’re highlighting adv….
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Beautiful work from @kriwacki in @NatureComms! .Eric Gibbs and colleagues study the interactions between nucleolar protein NPM1 and tumor suppressor p14-ARF within condensates, revealing new regulatory mechanisms. #NMR #SAXS .
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We have exciting news to share!.Abhay Kotecha (@abhaykot) is joining us as Senior Director of Technologies for Cryo-EM and Cryo-ET. We're thrilled to have him continue his great work in #CryoET, building on his innovation at @thermosciEMSpec. Welcome to @stjuderesearch, Abhay!.
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RT @IRBBarcelona: 📢Don't miss out on our plenary #seminar next week, with Dr. @TanjaMittag, from @StJudeStructBio @StJudeResearch:. 🤝Hosted….
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RT @StJudeResearch: St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomed….
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Still hot off the press — @kellogg_liz and colleagues present the first structure of a Fanzor2!.Fanzors are eukaryotic RNA-guided DNA endonucleases. With the available Fanzor1 structures, the new work offers a comprehensive view of the family's evolution.
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We end the symposium with closing remarks by Madan Babu @m_madan_babu. We thank all speakers and session chairs, and hope all participants enjoyed the exciting science and stimulating discussion. We look forward to continuing the conversation at the reception tonight and beyond!
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Final session is on designing function, chaired by @NancyRGough.@Markus Weingarth, @AlissaHummer and Alexandre Zanghellini @biopraxis talk about the latest advances in antibiotic and protein design, and glimpse into the future!#NMR #antibiotics #MachineLearning #AI #proteindesign.
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Our @TanjaMittag chairs the upcoming session exploring new approaches, featuring Stephan Rauschenbach @ESIBDLab, @IvetBahar and Francis O'Reilly @FJ_OReilly.#samplepreparation #MassSpectroscopy #ComputationalBiology #proteomics #SystemsBiology.
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We continue to explore #membrane signaling in the next session, chaired by Chia-Hsueh Lee @TheCHLeeLab, featuring talks by Willow Coyote-Maestas @willowcoyote, Nurunisa Akyuz and Justin English @JGEnglishLab.#transporters #channels #mechanosensation #GPCR.
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Very excited about the Keynote Lecture by Rod MacKinnon from @RockefellerUniv and HHMI, introduced by former mentee Chia-Hsueh Lee @TheCHLeeLab. The auditorium is jam packed!. #ionchannel #membrane signaling
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Our very own Liz Kellogg @kellogg_liz kicks off the next session, focused on nuclear transactions. We have 3 outstanding speakers: Yuh Min Chook @yuhminchook, Tatiana Kutateladze @CUAnschutz and Juli Feigon @FeigonLab.#cellnucleus #chromatin #telomerase.
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Looking forward to session on decoding protein structure and disorder, chaired by Scott Blanchard @TheBlanchardLab and featuring @TanjaMittag, Edward Lemke @LemkeLab and Kresten @LindorffLarsen.#integrative #IDPs #condensates.
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Session on #microbes and #pathogens, with more spectacular #CryoEM and #CryoET!.We have Susan Lea @S_M_Lea and the bacterial flagellum, and Mimi Ho @mimi1inh on an integrated approach to understand the native translation machinery in situ in #malaria parasites. #molecularmachines
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We are starting our 3rd Structural and Computational Biology Symposium!. Babis Kalodimos @KalodimosLab opens the event, followed by a session on structural cell biology chaired by Yiorgo Skiniotis, with Abhay Kotecha @AbhayKot and Shyamal Mosalaganti @s_mosalaganti #CryoET
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All ready for our upcoming symposium here at St. Jude. We have a stellar lineup of speakers and over 250 registered attendees!.Looking forward to two days of exciting science!
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