Our paper describing gene regulation in the fly brain is out now in @Nature! So proud of this one and of the amazing team work with @SaraAibar @ibrahimihsan and @joynismail in the @steinaerts lab! Check it out here https://t.co/gkFcgDtLKX with below our main findings:

Our ChromBPNet preprint out! Huge congrats to @panushri25! This was quite a slog for both of us but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Link in the next tweet. Bluetorial coming soon .. 1/

Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to @sdorkenw and Philipp Schlegel, first authors of the connectome papers, @MurthyLab @SebastianSeung for establishing #flywire to make this possible and @dddavi for birthing this dataset.

Happy to share CREsted, our latest package on enhancer modeling! CREsted allows for training sequence-based deep learning models from scATAC-seq data, enhancer decoding and enhancer design through a variety of methods. Check out the GitHub here: https://t.co/hesNelFprs. [1/9]

Last week I got awarded the @ASLeuven award for Biomedical Sciences @KU_Leuven for my PhD research 🪰🧠. Very proud and humbled to receive this award and eternally gratefull to all the amazing scientists who I was able to work with, especially my mentor @steinaerts! Thanks!!🙏🙏

The fly has a full #connectome, basically a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory? We move towards this answer, predicting transmitters from EM! w/@BobQubit, vid @amyneurons, 1/n Published @CellCellPress: https://t.co/yuWZEVWZkx

Very excited to announce our new preprint together with Nikolai Hecker! Dive into our findings on the conserved regulatory codes shaping cell identity across species. 🧬 [1/n] https://t.co/l0eCJXTTZ6

Do you love big data and the brain? We have #ScienceJobs for you! In Drosophila there are >11,000 cell types that define the circuit structure of the connectome – but we don't know their molecular identity. Integrating connectomes and transcriptomes would be revolutionary. RT 1/3

How much of our genome is 'noise' and how much is actually functional? In the de Boer lab's latest paper (along with @DarkMatterDNA) we aim to uncover the truth behind this long standing debate! 1/ https://t.co/68Pyt7JAPK https://t.co/Iis47rVz9Y

Thrilled to share my PhD work in the @TreutleinLab & @GrayCampLab! In this 🚨preprint🚨, we present an integrated perspective on how morphogens impact early human neural organoid development: https://t.co/yueNr6ULWb Tweetorial landing in 3, 2, 1...

Happy to announce the first paper of my postdoc in the @TreutleinLab! A fun collaboration with @HsiuChuan_Lin where we investigated how morphogen signaling pathways can be used to increase the diversity of TF-induced neurons. Check the paper here: https://t.co/ESPXwSOIF0!

Very happy to see my final PhD paper on designing synthetic enhancers for selected tissues in vivo using #AI out in @Nature 🥳 Big thanks to @AlexanderStark8 and whole @stark_lab , as well as collaborators in @Eileen_Furlong lab! Check out our thread below for more details 👇

Exciting news! Our latest research on "Cell type directed design of synthetic enhancers" has been published in @Nature. We've harnessed deep learning to design enhancers with cell-type specificity. Find our paper here: https://t.co/wC44fDMp70. Highlights below: [1/n]

We are recruiting! If you are interested in neuronal evolution or neuronal circuits or you just enjoy generating new tools in different bugs, please consider applying. If not, please retweet :-) More information by email or DM. You can apply here: https://t.co/DSqTwSwHxr

Extremely happy to be awarded an #ERCSyG grant @ETH_en @ETH_BSSE together with Elly Tanaka @Tanaxolotl @IMPvienna & Kevin Briggman @MPINB_outreach! In #AxoBrain, we will map cell types, architecture & circuits of the axolotl brain and explore its amazing regenerative capacity!

Human brain atlas papers by @kimsiletti @MossiAlejandro @ka_wai_rine @ErnestArenasSWE @EmelieBraun1 @MiriDanan Rebecca Hodge Trygve Bakken Ed Lein @LarsBorm Elin Vinsland Erik Sundström and many others. With a stunning double cover illustration by @IKapustova

36 datasets, 26 protocols, 1.7 million harmonized cells! First edition Human Neural Organoid Cell Atlas. Important work from @zhisong_he @josch_f Leander Dony @TreutleinLab @fabian_theis. Strong community effort @Sergiu_P_Pasca @GiorgiaQuadrato. #organoids @ETH_BSSE @IHB_Research

Spatial transcriptomics in adult flies! I feel rejuvenated by finding localised mRNAs in gigantic flight muscles, 20 years after studying bicoid mRNA in oocytes. Fantastic collaboration with @steinaerts @JasperJanssens7 @PierreMangeol & co-thank you all! https://t.co/aYRmcHGywn

And here are some more images for the road ;)

Massive thanks to @PierreMangeol, @KatinaSpanier and @joynismail for creating beautiful slices. To @gapartel, @NikolaiHecker, and @PierreMangeol for analysis and to @SchnorrerL and @steinaerts for mentoring. A fantastic and fun collaboration and very happy with the results!!! 🥳

and mapped unknown scRNA-seq clusters to spatial locations. Check out the paper for all details and analysis!