Elly Tanaka
@Tanaxolotl
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Regeneration Biologist
Joined February 2021
Prayag you beat me to it!😀. So happy to introduce you to this work on positional information in limb regeneration. And a huge applause to Akane Kawaguchi--chromatin artist and Jingkui Wang--computational wizard!!
Check out this exciting💥 MS on @biorxivpreprint from @hoyako & #Jingkui from the @Tanaxolotl. Epigenetic marks of hox loci during axolotl limb homeostasis & regeneration. Congratulation to all involved.👏 @IMPvienna @WHB_Masselink @VBCF_Tweets @CRTDpress
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The second study led by @ejhergenreder presents chemical strategy https://t.co/VDtHL5hAss, to drive maturation in human neurons. The new GENtoniK cocktail can drive maturation in multiple hPSC-derived cell types and trigger maturation related behavior even in non-neural lineages.
biorxiv.org
The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months and years to reach adult-like function. Prolonged...
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Why do human neurons mature so slowly? Two studies from the lab tackle this issue. The first study led by @gabriele_ciceri identifies an epigenetic barrier that sets protracted maturation timing of human neurons already at the neural precursor stage
biorxiv.org
The pace of human brain development is highly protracted compared to most other species. The maturation of cortical neurons is particularly slow, extending over months to years to reach adult-like...
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Yes so proud of Giacomo and Pietro--what a team!
After a fruitful stay in the Tanaka lab (@Tanaxolotl), undergrad @GiacomoGlotzer & his mentor Pietro Tardivo published their work @eLife. They report the unique expression of Canonical Wnt's targets in the axolotl #mesenchyme & more. 👇🏿 https://t.co/F3F4TIjkFF
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At a really nice meeting--seeing work on lits of amazing biology. So inspiring ( and happy that axolotl made it to the top models!)
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Big news! Endangered Art Books is teaming up with NY Times best selling cartoonist and professional amphibian enthusiast @Blackmudpuppy to bring you his latest educational comic book, Moistly Harmless! It'll be fun, funny - and full of newts!
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Yes! An amazing preprint on the Pleurodeles salamander forebrain and its evolutionary implications. Congrats @matosches and lab!!!!💕
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Congratulations @LeoOtsuki for your eliquent chapter one of the fundamental topics in regeneration covered in this book!
Just received the @CSHLPress textbook on Regeneration - a true beauty in print! Thanks to @Tanaxolotl and editors @FoxLabDuke and @Ken_Poss_Lab for the opportunity to contribute, and particularly to Moritz Wegscheider for his cover illustration accompanying our chapter! 😍 1/2
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Cool new concept in a 24 hour round the world meeting!!
The International Society for Regenerative Biology invites you to an exciting Around the World Event! Abstract deadline extended! - https://t.co/Qqvb72QqgF
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...and of course so proud of Katharina, Ashley, Tomas and Jonas in this great collaboration with @TreutleinLab !
What secrets does the amphibian #brain hold? We used single-nucleus sequencing @10xgenomics in #axolotl to find out! Exciting collaboration with @AshleyMaynard10, @tomsgoms, @josch_f, @GrayCampLab, @Tanaxolotl and @TreutleinLab! https://t.co/LGQtEQImz8 🧵👇 1/19
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DOI: 10.1038/s41467-022-28755-1 Catarina Oliveira in Mas Yun’s lab uncovers Tig1 as another component of the pathway that can promixal positional identity in the regenerating axolotl limb.
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DOI: 10.1038/s41467-021-26321-9 Lizard tails show defective spinal cord regeneration that is dominated by sonic expressing cells that cause the tube to be encased in cartilage. Tom Lozito “repaired” this defective patterning by transplantation of CRISPR edited, Smo-/- NSCs
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After tweet holiday, some cool papers DOI: 10.7554/eLife.68584 Kaylee Wells in Kate McCusker’s lab by cross transplantation of tissues between large and small animals, she shows that matching of limb regenerate to the size of the host depends on a nerve mediated process
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Yes! Nominate the regenerative biology scientists you admire most!
New ISRB awards for regenerative biology! See https://t.co/KyNVR4r9ob and nominate your colleagues for Rising Star Award or Lifetime Achievement Award. Nominations due Jan 31, 2022.
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🚨🚨🚨Exciting meeting (in person!) in Vienna this spring!! Come talk about #stemcells with great ECR (@Marta_Shahbazi @MoritzMall) and confirmed ones 😉 (@chribue @NRivron @Tanaxolotl @briscoejames ) Yes I’m biased 🤗 @viennabiocenter @IMPvienna @IMBA_Vienna
#biology #meeting
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We look forward to welcoming the stem cell community back in Vienna next year at #SYStem2022! Keynote speakers are Kathrin Plath @PlathLab and James Briscoe @briscoejames Find out more at ➡️ https://t.co/u5dkeTZ4Rm
@IMPvienna @MaxPerutzLabs @viennabiocenter
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Fantastic opportunities for experimentalists and theorists at @EMBLBarcelona Not one, but two group leader positions Couple weeks left to apply https://t.co/2Br58z4MDE
embl.org
At EMBL Barcelona, we study how tissues and organs develop and function in health and disease
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Sounds very exciting! "alterations subvert the formation of the chick primitive streak into the gastrulation modes seen in amphibians, reptiles and teleost fish [..] suggests that the evolution of gastrulation movements are largely determined by the shape of and cell behaviours"
Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviours in the chick embryo
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Congratulations Leo for this very thoughtful review!
When an organism regenerates limb or spinal cord, how does it 'know' which part to regenerate? Could it regenerate the wrong body part? Very happy to share our review celebrating 100 years of studying positional memory in vertebrate regeneration. A🧵(1/6) https://t.co/FsLDh8l3G0
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