Fátima Sanchís-Calleja
@fatima_snc
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she/her | On a journey from neural organoid patterning @TreutleinLab @GrayCampLab (PhD @ETH_BSSE) to the cycling endometrium @karalmckinley lab (Postdoc @HSCRB)
Joined July 2009
If you're into 🧠organoid morphogenesis, this is your call 🤙
TOMORROW: DDD seminar, Tue. July 23, 2024 @ 1pm Eastern US. 2 talks on in vitro cerebral organoid regionalization from @TreutleinLab: Dr. @fatima_snc and Dr. @Jain_Akanksha_. seminar info:
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🚀Super happy that our latest research has finally been published in @NatureNeuro! We delve into the world of human neural development. Our findings shed light on the dynamic epigenetic changes that guide cell fate from pluripotency to fully differentiated neural cells.🧠🔬🧵
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Huge thanks to everyone contributing to this preprint in the @GrayCampLab & @TreutleinLab: @Jain_Akanksha_ @zhisong_he @JasperJanssens7 @josch_f & Ryoko & Gosia & Makiko, with special mention to our amazing collaborators @Kirkeby_Lab @gauravsinghrat & Pedro & Charlotte 👏🎉
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If you want to know more, dive into many more details in the manuscript! 🧐🤓 https://t.co/gcUS6JyZU0 And, most importantly...
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(6/6) We also compared dorso-ventral forebrain patterning using microfluidic gradients 🌈 (the amazing “MiSTR” from the @Kirkeby_Lab) with step-wise changes in morphogen concentrations🪜 The same regional cell types emerged... but in different proportions 📊
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(5/6) We found that the choice of neural induction media 🧫🧠 can lead to different patterning outcomes 🐪🐫 in response to the same morphogen treatments.
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(4/6) Our screen included different cell lines, which produced similar cell types with varying efficiency 🥇🥈🥉in response to the same morphogen treatment.
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(3/6) We could also delimit patterning windows 🪟 for each morphogen and detect powerful interactions 💬between different morphogen pathways.
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(2/6) We examined the induced cell types and regulons, noting that the effects of some morphogens are highly time-dependent 🕙, while others are more concentration-dependent 📶
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(1/6) We systematically tested variations in morphogen concentrations📶, timing 🕙, and combinations🧩over 97 conditions, using a multiplexed single-cell transcriptomic screen.
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Thrilled to share my PhD work in the @TreutleinLab & @GrayCampLab! In this 🚨preprint🚨, we present an integrated perspective on how morphogens impact early human neural organoid development: https://t.co/yueNr6ULWb Tweetorial landing in 3, 2, 1...
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I am very excited to share my postdoc work “Morphodynamics of human early brain organoid development”, where we take a multiscale morphodynamic view of human brain organoid development. In collaboration with @GillesGut @GrayCampLab @TreutleinLab
https://t.co/3I96Gl1KbL🧵(1/9)
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A new collaboration between @ETH_en and @Roche trains doctoral students and postdocs in bio-engineered #TranslationalMedicine in Basel. The call for applicants for the doctoral programme is open now > https://t.co/sYcnkOn8nk. Please RT!
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Exciting times at @IHB_Research! A new PhD program with @ETH_BSSE -> https://t.co/17h5Q3Gakr. A search for new group leaders (early career) -> https://t.co/CdcRHL2kG6. It is a very interesting intersection at the moment: Exploration, Engineering, Translation! #Organoids #Basel
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📢Sign up now! Registration is open until 7 April 2023 for the 2nd annual #BaCell3D meeting on 8–9 May 2023 in Basel🇨🇭! The meeting will focus on the latest developments in #organoid and #3D model research! For more information visit our website! https://t.co/Zh2odqvqI1
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Ever wonder what a piece of marble has to do with cell death🤔? My friend @GesuitaLorenzo made the most amazing video series where he explains brain development🧠 using art analogies. So beautiful🤩! Everybody go check it out!! https://t.co/sI26Eeo6Ns
THE BEAUTIFUL BRAIN, the web series that breaks down boundaries between Science and Art, is finally online! Check it out! https://t.co/Y8uHyhzPpj
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Please retweet: Two PhD positions are available in my new lab at @UZH_en. Interested candidates can contact me directly or apply via the @LifeScienceZH Graduate School. Application deadline December 1st 2022!
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Finally this baby is out!! A big thank you to all the amazing collaborators! ❤️@VerdonTaylorLab Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis
embopress.org
image image Understanding brain development requires detailed insight into the temporal transcription dynamics associated with cell lineage determination. This genome‐wide profiling study provides a...
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Comprehensive cell atlas of the first-trimester developing human brain https://t.co/nzEPAIkJ7S
#bioRxiv
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Happy to see JiSoo Park’s work on mouse neural tube organoids published https://t.co/rZyDHby1fk 👏🎉!! Not quite a #SyntheticEmbryo… but still impressive display of the self-organization capacity of stem cells. Check out the neural crest cells that emerge from these organoids!
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