The Jackson Laboratory
@jacksonlab
Followers
21K
Following
26K
Media
5K
Statuses
23K
Est. 1929, JAX is a non-profit scientific research institute specializing in 🧬 genetics, 🧮 genomics & 🐁 mouse models of disease. https://t.co/SrWBTGUJ00
Joined June 2009
It's not always about researching what goes wrong when we age -- but what goes *right* in those with long and healthy lives:
6
39
105
Calorie-restricted mice can live incredibly long life spans -- some reaching a human age equivalent of 160 years:
13
35
84
$3.2M grant goes to JAX's @albertwcheng!.👉 “This toolkit will transform the ways we study #epigenetics by providing a fine and scalable technique to directly edit epigenetic states at defined targets.”
0
17
82
It started with an idea from @futuredrdukes, and within a few weeks, nearly 2 dozen neuroscientists banded together to create @BlackInNeuro. The goal: to develop a community for Black scientists who often feel alone or overlooked. Read more from @statnews:.
0
27
83
Bioinformatics is an indispensable part of life science. However, most professors did not study it during their own training. To address this, a team including JAX's @jeffgenome developed a short course to train profs with these essential skills:.
0
29
79
A big welcome to new Assistant Professor @ewang2323! Eric joins the JAX Genomic Medicine faculty to devise new strategies to overcome drug resistance in cancers such as acute myeloid #leukemia:.
5
4
82
🐁 Play with our animated JAX mouse #nomenclature tutorial and learn key details about your strain of choice:
0
13
78
In @naturemethods, a new 3D culture technique enables mouse Sox9+ embryonic lung progenitors to expand long-term, generate all epithelial lineages:
5
27
58
JAX's Stitzel receives a $1.6M Pathway to Stop Diabetes Accelerator Award from @AmDiabetesAssn to pursue #type2diabetes research:
1
16
62
🎵 Back by popular demand. this week we feature JAX's 'Splice Girls' 🧬 . Splice, as in RNA splicing-- we have multiple ongoing research projects about splicing here at JAX:.
4
7
66
New in @CellStemCell, @FlorianMerkle @Michael_E_Ward_ @MarkRCookson1 & JAX's @BillSkarnes labs I.D. the KOLF2.1J iPSC line as having high genomic stability post editing, allowing the modeling of 💯s of genetic alterations relevant to disease:
0
14
63
BREAKING 🗞️: We're sending "Mighty Mice" to space! 🐁🚀. Over 4️⃣0️⃣ days in space aboard the @ISS_CASIS, JAX mouse models will be used to study the effect myostatin (a 🧬 pathway that inhibits 💪) has on muscle loss in microgravity. Stay tuned for #miceinspace updates:
2
30
70
🎉🧠 Congrats to the @KaczorowskiLab on receiving a $6.8M grant from the National Institute on Aging to study cognitive aging: .
1
7
58
We are so lucky to have brilliant, dedicated scientists like @Laura_Reinholdt continue their work at JAX after starting their careers here. Congratulations on your promotion Laura, wonderful work! 💯
1
5
62
🎉 Today we celebrate our 90th birthday!! Our long history includes .some great (🏅) and tough (🔥) moments, but we've chosen a few that best represent who JAX is. Visit our birthday page to get to know more about your favorite nonagenarian!
6
15
61
💪 An immunotherapy used against cancer is now armed for the fight against #COVID19! New in @ClinTransImmuno, JAX's @Derya_ lab generates anti-Spike & anti-ACE2 T-cells for CAR-T therapy that can track & eliminate COVID-19 infected cells:.
4
21
55
Now accepting JAX #Scholarship applications from teachers for students entering college and meeting these criteria:
2
20
49
📣 We are pleased to welcome world-class data scientist @PaulFlicek as JAX's inaugural Chief Data Science Officer. In this new leadership role, Flicek will be responsible for building and executing a comprehensive #datascience strategy across JAX:.
7
4
56
New mouse atlas allows scientists to crowdsource brain-imaging data to easily share data, results with collaborators. New in @NatureNeuro via @Spectrum:
1
31
56
🎓Announcing Emaly Piecuch, Ph.D., and Jufen Zhu, Ph.D.-- the first 2 grads from JAX/@uconnhealth's joint doctoral program: .
0
10
55
New study shows that gut 🦠 and the 🧠 may communicate bidirectionally. Via @nresearchnews, @MireiaVallesc shows an association between specific bacterial genera and mental wellness. @VIBLifeSciences @VIB_microbes:.
2
30
49
“At JAX we are committed to finding #Alzheimers treatments and even stopping it before it starts," said JAX Pres & CEO @liuedison, in response to the new Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act, authored by @SenatorCollins:
40
8
50
Certain dog breeds have a ⬆️ risk of getting difficult-to-treat glioblastomas. By studying donated pet tumor samples, JAX's @roelverhaak is trying to find a treatment for dogs AND dog's best friend:
2
31
48
A @GHowell_Lab team showed significant differences in microglial gene expression & activation states in 3 wild-derived & 1 B6 strains of healthy & #Alzheimers disease mouse models. @StanleyHYang @cowabunga314 @kwangbom @genomequant @gwcarter: .
0
23
42
It started with an idea from @futuredrdukes, and within a few weeks, nearly 2 dozen neuroscientists banded together to create @BlackInNeuro. The goal: to develop a community for Black scientists who often feel alone or overlooked. Read more from @statnews:.
0
10
48
Congrats to @KaczorowskiLab postdoc Amy Dunn, who received a fellowship from @alzassociation to continue her studies of how genetics and diet interact to determine #Alzheimers risk:
1
14
46
🎊 Congratulations to JAX's Jennifer Trowbridge (@TrowbridgeLab) who received a prestigious Emerging Leader Award from @TheMarkFdn. Trowbridge is 1 of 6 outstanding early-career investigators working on projects addressing unmet #cancerresearch needs:.
0
3
48
New Journal of Neuroinflammation paper from @StanleyHYang & @GHowell_Lab further supports the model that peripheral myeloid cells enter the 🧠 in response to diet-induced obesity:.
0
10
49
💻 Bioinformatics is an indispensable part of life science. However, most professors did not study it during their own training. To address this, a team including JAX's @jeffgenome developed a short course to train 👩🏫 with these essential skills:.
0
14
43
JAX's Catherine @KaczorowskiLab appointed chairholder of the "Evnin Family Endowed Chair in #Alzheimers Research" established with a $1.5M gift from Judith and Anthony Evnin, Ph.D.:
8
11
48
It started with an idea from @futuredrdukes, and within a few weeks, nearly 2 dozen neuroscientists banded together to create @BlackInNeuro. The goal: to develop a community for Black scientists who often feel alone or overlooked. Read more from @statnews:.
0
22
42
Thanks to funding from @theNCI & @NIH's National Institute on Aging, JAX's @TrowbridgeLab seeks to advance the understanding of the role of #aging in #cancer. Joining her will be collaborator, @RossLevineLab @sloan_kettering: #CancerResearch
2
3
43
📣We are excited to announce the appointment of Lon Cardon, PhD, FMedSci as JAX’s next President and CEO. A pioneer in human genetics & drug discovery, Cardon joins us from BioMarin Pharmaceutical and will succeed Ed Liu, M.D. after a decade of leadership:
0
15
46
Large segments of our 🧬 can be duplicated, deleted or inverted. These variants have been associated with disease. A recent @CellCellPress paper from @christinerbeck's lab sheds light on the mechanisms that cause these genomic structural variants:
0
17
36
📙 New in @CD_AACR: "Natural coevolution of tumor and immunoenvironment in glioblastoma" with @roelverhaak: .
0
9
46
💿 @backstreetboys just dropped a new album called 'DNA' -- but our own BACstreet boys (as in Bacterial Artificial Chromosome) are hard at work today too. 📸 George, Danya, @Alexander_Fine, Joe, Andrew (L➡️R):
2
6
39
😂 #FridayFunny! We've all been there after a long day in the lab. 😎 . 📸 : meme credit to u/ThunderKant_1, submission from @dayanaknits.
0
8
43
New in @NatureComms, JAX's @christinerbeck lab studies the role of transposable element-mediated rearrangements (TEMRs) in generating human diversity, finding them responsible for ~10% of structural variants in human genomes:
0
8
41
🎉 Congratulations to Associate Professor Jennifer Trowbridge, Ph.D., (@TrowbridgeLab) the inaugural Dattels Family Chair. We thank JAX trustee Tim Dattels and his family for this newly established endowed chair:.
2
2
42
Congrats to @EwelinaBolcunF for receiving a $2.1M grant from @NICHD_NIH to study how multiple genetic factors regulating #oocyte development determine differences in each woman’s ovarian reserve:
1
7
37
We're partnering with the @CTDPH, @uconnhealth, and @hartfordhosp to provide Connecticut with additional COVID-19 diagnostic testing capacity: .
0
19
39
$3.5M @NIH grant awarded to JAX's Lutz and Murray to develop reporter mouse models, specifically for testing and monitoring gene editing activity, as part of the Somatic Cell Genome Editing program initiative: .
1
12
43
Mighty Mice are scheduled to launch today! 🐁🚀 JAX, @uconnhealth, & @ctchildrens @SeJinLee17 & @EmilyGermainLe1 are co-investigators on this @ISS_CASIS project. Stayed tuned 👀 for live tweets or visit our #miceinspace ⬇️ page for updates:.
4
13
38
A $10.6M @nih grant funds a new JAX center for rare genetic disorders. “So much of the burden of pushing for cures for rare diseases has been on the shoulders of parents. It’s unfortunate and it’s about time that changed," says JAX's Cat Lutz:.
2
22
42
JAX's @VivekDNA received a $467,500 grant from @NIDAnews to use innovative AI tech to 🔎 how 😴 & social behavior influence #addiction:.
6
5
38
JAX's @Derya_ lab & colleagues @BatemanHorne shared a preprint analyzing immunological differences between #mecfs patients and healthy controls:.
0
14
43
"Neurons are super interesting electrical devices and visualizing them helps you figure out the functions they serve." . Neuroscientist @ErikBloss joins JAX as Assistant Professor, bringing high-res instruments & techniques to image #neurons 🧠🔬:.
1
8
39
The @NIGMS awarded a 5️⃣-year, $2.1 million grant to JAX's @OlgaAnczukow to reveal the role of splicing-factor defects in cardiac or neurological disorders, cancer and more:.
3
4
40
Congratulations to @florisbarthel of the @roelverhaak Lab for receiving a prestigious K99 award from @theNCI to determine how cancer cells achieve immortality:
2
3
39
Changes in sleep-wake patterns & circadian rhythm could be early signs of #alzheimers. JAX's Vivek Kumar has received an NIA grant to launch “Impacts of Sleep and Circadian Biology on Alzheimer’s Disease and Aging: A Focus on Genetics and Genomics,” starting in October 2021. 💤
1
8
36
👏 A big congratulations to JAX Assoc. Professor @garethhowell10 @GHowell_Lab for being named Diana Davis Spencer Foundation Chair for #Glaucoma #Research:
1
8
37
🎖️ Congrats @mathandel for this well-deserved award from @SSRepro! The Jansen Distinguished Service Award recognizes “an individual who has demonstrated unselfish service & leadership in advancing the discipline of reproductive biology:"
3
13
32
JAX has established a $1 million fund in honor of Kenneth “Ken” Paigen, Ph.D. (1927 – 2020) and Beverly “Bev” Paigen, Ph.D. (1938 – 2020) for the benefit of @JAX_Education's postdoctoral program:.
0
8
35
So excited to read these #BlackInGeneticsWeek features from @BlackInGenetics. ⬇️ Below is the founder of the group @stutzman_alexis. We will be retweeting more features as the week goes on, but go follow @BlackInGenetics to see ALL of them. 🧬.
1
6
35
Congrats to JAX's Leah Graham on being appointed to chair of the board of directors for @MCOAging: .
1
2
35
A very special $2.8M "New Innovator Award" from the #NIHHighRisk High-Reward Research Program goes to JAX.
3
14
34
🕯 We are sad to share that Ken Paigen, professor emeritus and former JAX director, passed away this weekend surrounded by his loved ones. Born in 1927, Ken was a brilliant scientist, a treasured colleague and mentor, and a towering figure in JAX’s …
1
6
34
JAX's @christinerbeck looks into quirky segments of DNA that were once considered 'junk' 🧬-- "A lot of the beauty in our biology is in the smaller, more nuanced things that people initially cast off as uninteresting." #junkDNA #transposons.
2
9
36
Not a bad view for a parking lot! That’s #acadianationalpark’s Champlain Mountain watching over us on our Bar Harbor, Maine campus. 🏞. #mainelife #barharbormaine #barharbor #ilovemaine #acadia #mountdesertisland #nonprofit #researchinstitute #resear…
3
5
36
🔬🐁 Exciting news from JAX! A research team led by @Vivekdna has developed a stress-free, computer vision-based method to weigh mice. This innovative approach promises more accurate data, enhancing the quality of preclinical studies.
1
14
38
Biomedical researchers worldwide recognize that a lack of data science expertise limits research progress. 📉 JAX offers a bioinformatics training program that equips researchers with critical data science skills:.
0
13
35
Congrats to Gareth Howell & Kristen Onos on receiving the 2021 AD Strategic Fund: Neuroimmune program grant from the @alzassocation for deciphering microglial responses to amyloid and tau with wild-derived mice! 🎉
0
5
34
JAX's @TrowbridgeLab recently received @ISEHSociety's Janet Rowley Award! 🎉 Trowbridge studies cell fate regulation within the hematopoietic system and received this award for her contributions to the field of #cancerresearch: .
3
6
35
JAX CEO Ed Liu hosted @PatrickDempsey and the @DempseyCenter yesterday at our #Maine headquarters. #cancerresearch
0
9
33
Registration for Teaching the Genome Generation is available now! 🧬 #TtGG is a @JAX_Education professional development short course (PAID 💸) for STEM teachers interested in genomics & personal genetics:.
0
12
32
A new method, called ChIA-Drop, applies recent advances in microfluidics for droplet-based, barcode-linked sequencing. Just published in @Nature, JAX’s Ruan and Wei show how ChIA-Drop captures complex chromatin interactions with unprecedented resolution:
0
29
35
👇🏿👇🏿👇🏿👇🏿👇🏿👇🏿👇🏿👇🏿👇🏿👇🏿👇🏿.👉🏿👇🏾👇🏾👇🏾👇🏾👇🏾👇🏾👇🏾👇🏾👇🏾👈🏿.👉🏿👉🏾👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👈🏾👈🏿.👉🏿👉🏾👉🏽👇🏼👇🏼👇🏼👇🏼👇🏼👈🏽👈🏾👈🏿.👉🏿👉🏾👉🏽👉🏼👇🏻👇🏻👇🏻👈🏼👈🏽👈🏾👈🏿.👉🏿👉🏾👉🏽👉🏼🚀🐁🚀👈🏼👈🏽👈🏾👈🏿.👉🏿👉🏾👉🏽👉🏼👆🏻👆🏻👆🏻👈🏼👈🏽👈🏾👈🏿.👉🏿👉🏾👉🏽👆🏼👆🏼👆🏼👆🏼👆🏼👈🏽👈🏾👈🏿.👉🏿👉🏾👆🏽👆🏽👆🏽👆🏽👆🏽👆🏽👆🏽👈🏾👈🏿.👉🏿👆🏾👆🏾👆🏾👆🏾👆🏾👆🏾👆🏾👆🏾👆🏾👈🏿.👉🏿👆🏿👆🏿👆🏿👆🏿👆🏿👆🏿👆🏿👆🏿👆🏿👈🏿. #miceinspace.
0
6
32
"The lack of diversity in our databases and genomic studies should be considered a problem for the entire life-science community, and together we must strive to address it." -JAX's Scientific Director and Professor Charles Lee, in @TheScientistLLC:.
0
18
33
$10.6M grant to JAX Prof @Derya_ for #mecfs center to track down immune, metabolic & #microbiome changes in disease:
0
15
29
👨🔬 “A good scientific mentor respects their trainees and treats them from the outset as a future peer rather than a cheap pair of 🙌.”. This and more advice from JAX Assistant Prof & scientific mentor @stevemunger: .
0
12
33
What mouse ages correspond to aging events in the human lifespan?
1
26
32
🤘How COOL is this shirt?. Credit: headbanger scientist 👩🔬. #cooltshirt #tshirt #scienceshirt #sciencejokes #sciencejoke #genetics #genomics #scientistsofinstagram
1
3
31
🐁 ➡️ 💊 '18 Breakthrough prize goes to the researchers behind Spinraza-- a drug that evolved from a JAX mouse model:
0
7
34
🧠 New research was recently published in @alzdemjournals on how genetic contexts can affect early-stage #Alzheimer's disease's impact on neuronal circuits. The JAX team included first author @Heuerwego, @ErikBloss & @garethhowell10:.
1
6
30
🎉 JAX has appointed 3 faculty members to endowed chairs in order to further research into Alzheimer’s disease, addiction, cancer, and computational biology. Gregory Carter, Ph.D. , (⬅️) has been appointed to The Bernard and Lusia Milch Endowed Chair …
0
3
28
#Postdoc job of the week: Join the @TrowbridgeLab to investigate the biological mechanisms that cause, and may be targeted to prevent, functional decline of blood and immune systems during aging:. #postdocs #postdocjobs #sciencetwitter
0
18
31
🗞 The social media team dove into the JAX news archives this morning and found this note written by Ken Paigen, former Director at JAX, to employees following the 🔥 of 1989. His joining the lab that year was, in fact, a kind of trial by fire. After…
0
5
32
😊.
0
0
33
3
24
31
This @biorxivpreprint is about natural genetic variation determining microglia heterogeneity in wild-derived mouse models of #Alzheimers disease. Out now from @GHowell_Lab, @gwcarter, @genomequant, @kwangbom, @cowabunga314, & @StanleyHYang:.
0
7
29
A new study identifies shortcomings in PhD training when it comes to career planning and awareness, in PLoSONE.
3
21
31
Congrats to Gareth Howell & Kristen Onos on receiving the 2021 AD Strategic Fund: Neuroimmune program grant from the @alzassociation for deciphering microglial responses to amyloid and tau with wild-derived mice! 🎉 @GHowell_Lab @cowabunga314 @garethhowell10
0
3
31
Commonly used mouse models are not optimal for studying infections of the newly discovered coronavirus due to differences in immunity. A transgenic model is now available to fill the unmet need for an in vivo experimental platform for COVID-19 research:
1
16
30
Chan Zuckerberg Initiative @cziscience awards JAX's @duyguucar funding as part of the Human Cell Atlas project ➡️➡️ A global, collaborative, multidisciplinary effort to catalog all the cells in the healthy human body:
4
6
29
🐁 🧬 The Cre/lox system is one of the most powerful tools in the mouse geneticist’s toolbox, giving exquisite control over the location and timing of gene expression. What does this mean? Check out this 2-part blog from our archives to find out!.
0
9
27
Congrats to @Dumont_Lab on receiving a @NSF grant to identify the causes of natural variation in recombination 🧬: .
0
7
28
C57BL/6 is the most widely used mouse strain in research. But how does the reference genome compare to founders 26 generations 🔙? JAX's @Laura_Reinholdt & team re-derived 1st-gen "Eve" to ID structural variants, close seq gaps & add annotation depth:.
0
8
28
🎉 Congrats to JAX's Charles Lee & team on receiving nearly $11M from the National Human Genome Research Institute to identify the full spectrum of haplotype-resolved structural variation in human genomes:
2
8
29
A nearly $50 million grant renewal has been awarded to @Model_ad_alz (incl. JAX researchers @gwcarter, @garethhowell10, @MikeSasner) by @NIHAging to bolster ongoing preclinical research into late-onset #Alzheimers disease:.
0
3
26
#Postdoc #job of the wk: Apply novel high-throughput genetic techniques (MPRA & CRISPR based screens) to comprehensively characterize non-coding regions of the genome to interpret the regulatory grammar of gene expression; @RyanTewhey Lab:
2
6
27
New study shows that the gut 🦠 and 🧠 may communicate with each other to affect mental wellness. Via Nature:
1
12
27
Boss: You are only here because of new hiring regulations.King: We’ll see how long you feel that way #discoversBRCA1.
0
15
24
💻 In this workshop, expert #longreadsequencing users & tech developers will guide you through the different uses of sequencing platforms like @PacBio, @10xGenomics, @bionanogenomics & @nanopore:
0
13
29
JAX/@TuftsUniversity graduate student @Alexander_Fine, from JAX's @gwcarter and @mathandel labs, highlights the importance of combining 💻& 🧪analysis. New study out in @ASCBiology:.
2
6
27
🎉 6️⃣ of our faculty received Maximizing Investigators' Research Awards from the @NIH. Congrats Chris Baker, @christinerbeck, @Dumont_Lab, @KeShengdong, @shengli_jax, & @stevemunger!.
0
10
27