PacBio
@PacBio
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Our mission is to enable the promise of #genomics to better human health by creating the world’s most advanced #sequencing technologies. #PacBio
Joined May 2009
Luckily, you don't have to wait long for results on the new Sequel IIe System.
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Join our educational webinar to learn the basics of DNA Sequencing! Find out why long reads are beneficial & get your questions answered by our panel of sequencing gurus: @lissagoingviral @OlgaVPettersson & Michael Hardigan @UCDavisPlants .Register:
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BREAKING: Today, we announce our new collaboration with @Google to use machine learning to optimize long-read sequencing data analysis. #HiFiSequencing. Read more here:
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DNA Extraction Tip 3: When sequencing plants, it is recommended to obtain the youngest leaf/shoot tissue from an individual plant that has been dark treated (kept out of light) for 24-72 hours. #Sequencing101 . More at:
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What exactly is "SMRT Sequencing"? What are "long reads," for that matter? Confused about some of the basics of DNA sequencing, but too afraid to ask? Fear not, friends. We're offering a free Sequencing 101 webinar to break it down for you. Feb 27.
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It's here! We’re thrilled to announce the launch of the Sequel II System, reducing project costs & timelines with approximately eight times the data output compared to the previous Sequel System. Look at that beauty! 1/3
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We’ve partnered with the @broadinstitute and @10xgenomics to launch the Multiplexed Arrays Sequencing (MAS-Seq) kit, an accurate and cost-effective long-read single cell #RNASeq solution. Learn more here: #PacBio #ASHG22.
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We are thrilled to announce a new collaboration with medical genetics leader @Invitae to develop an ultra-high-throughput clinical whole genome #sequencing platform. See the details:
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Felicidades, @guarnitron & co of the @CrawLab at @Uniandes! You've been crowned winner of the 2020 Plant & Animal #SMRTGrant! You clearly had many fans (6.264 votes, to be exact) & we truly hope your project will help #SaveTheToads.
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"We have entered a new era of insect genome biology." New preprint from @MtnScience @paulbfrandsen @joannalkelley @John_S_Sproul @AmLarracuente et al examines how long-reads are revolutionizing #entomology & where gaps still remain.
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Checkmate, Chromosome 8: The First End-to-End Sequence of a Human Autosome. Congrats to @glennis_logsdon & the #T2T team on this amazing work! #HiFiReads
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From shipping container to lab floor, the Broad Institute welcomes its first early-access Revio.
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What an epic way to usher in a new era of #sequencing and the announcement of our two new systems, Revio and Onso, with an amazing performance by Maroon 5! . #PacBio #ASHG22
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Another novel way to explain the semantic dependence between the negation of exons, via @hagentilgner in our #ASHG20 #PBWebinar
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Super news from @sangerinstitute! The UK hub of the @darwintreelife & other human & pathogen genetics projects has purchased 7 new Sequel IIe Systems, to add to their 5 current Sequels. They plan to sequence ~2,000 plant & animal genomes in the next 2yrs!
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NEWS FLASH: The kit you've been eagerly awaiting is now available! The SMRTbell gDNA Sample Amplification Kit enables whole genome amplification starting from as little as 5 ng of genomic DNA. Find out more about it & our ultra-low DNA input workflow
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Back to School! Have you checked out our #Sequencing101 series? Whether you're a novice or a pro, you're bound to learn something new!. Evolution of DNA Sequencing: Sequencing steps: Understanding accuracy:
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BREAKING: @ChildrensMercy invests in 4 additional Sequel IIe Systems, enabling the top pediatric center to scale up its innovative whole genome research into #rarediseases. Its 6 Sequels will be installed in the new nine-story @ResearchCM building.
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"We have entered a new era of insect genome biology." New preprint from @MtnScience @paulbfrandsen @joannalkelley @John_S_Sproul @AmLarracuente et al examines how long-reads are revolutionizing #entomology & where gaps still remain.
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Announcing Sequel System 6.0 - what will you do with highly accurate single-molecule long reads? #PoweredbyPacBio.
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IT’S OFFICIAL: PacBio Closes Acquisition of Omniome. Today marks the beginning of a new era! Long-read and short-read #sequencing platforms together under one roof. The next step in enabling the promise of genomics to better human health 🧬 Learn more:
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🦇 Happy #BatAppreciationDay! 🦇. These little balls of fluff are called Honduran bats, also known as Caribbean white tent-making bats, native to the rainforests of Costa Rica. H/T @IFLScience & Milan Zygmunt
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We are excited to partner with @GeneticNijmegen on #raredisease research. Using #Revio, we may be able to identify key variants at scale with extraordinary accuracy and make a real difference in providing rare disease answers.
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BREAKING: PacBio Signs Definitive Agreement to Acquire Omniome!. Our combined forces will challenge the status quo of conventional NGS. How?. Click here to learn more
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A gift for entomologists & geneticists alike! New low-input protocol makes it possible to create high-quality genomes from a single insect. See what @drsarahdoom & @sangerinstitute achieved together in this @biorxiv preprint:
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"We have entered a new era of insect genome biology." New preprint from @MtnScience @paulbfrandsen @joannalkelley @John_S_Sproul @AmLarracuente et al examines how long-reads are revolutionizing #entomology & where gaps still remain.
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Want to learn about long-read sequencing? Attend our webinar on Feb. 27 to get an intro to our technology & its applications, followed by a panel discussion among experienced users: @lissagoingviral, @OlgaVPettersson, & Michael Hardigan from @UCDavisPlants
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✨It's here! Introducing Vega - the first benchtop long-read #sequencing system from #PacBio. With #Vega, industry-leading HiFi tech is now within reach. We could go on about why it's so remarkable, but Vega's impact speaks for itself. Learn more here:
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The largest genome (5 Gb) broke almost every tool commonly used in assembly processes, but they did it. AND created some cool new tools & super science along the way. Huge congrats to the @genomeark team on their #VGPFlagship release & @nature special!
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NEW: The power of #PacBio #HiFisequencing shines in this @nature article highlighting the TRGT method, enabling unprecedented detection and comprehensive discovery of repeat expansions linked to dozens of monogenic diseases and #cancer.
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Today we announced that our new HiFiViral SARS-CoV-2 solution has successfully sequenced & captured the entire genome of the #Omicron variant lineage. Read our press release, including results from @inqababiotec, to learn more:
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Highly accurate, no gaps, no mis-joins — just chromosome 8 in all its glory. The completion of the first-ever fully sequenced human autosome is a remarkable feat and we are honored that PacBio #HiFiReads played a pivotal role in helping to achieve it!
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“We are now embarking on an era where all genetic variation in an individual will be completely discovered. Hundreds, and ultimately thousands, of new human reference genomes will be produced.” @glennis_logsdon @mrvollger & Evan Eichler in @nresearchnews
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News about a new 'complete' human genome was v exciting. What does it mean & how did #HiFiReads help the #T2T team fill in the final 8% gap? We dive in on our blog: Insider insight from @ArangRhie #SMRTLeiden talk also available:
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Happy #DNADay2021! Want to learn a bit more about DNA sequencing? We've got the series for you:. Evolution of tech: Sequencing steps: Ploidy, haplotypes & phasing: #Sequencing101
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Tracking the SWEET tooth of TALEs: @AdamBogdanove of the @BogLabCU has used SMRT Sequencing to uncover host resistance to rice and cotton pathogens. Learn more about his work with TAL effector genes &the creation of a 'TALome'
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Researchers have sequenced all the centromeres in a multicellular organism showing that telomere-to-telomere assemblies are now possible! Congrats to @AmLarracuente & her colleagues @UofR who used SMRT Sequencing for the study published in @PLOSBiology
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When preparing samples for HiFi sequencing, you not only want DNA free from nicks and degradation, but you also want long fragments (tens of kilobases) to achieve those coveted long reads. Get some top DNA extraction tips on our latest #Sequencing101 post.
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We’re excited to announce new long-read #sequencing chemistry for #Revio that will increase the system’s output & enable customers to reduce their sequencing cost per genome by up to 50%. Discover more enhancements here: #PacBio #ASHG24
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NEWSFLASH: Today we're launching new HiFi Sequencing workflow & software updates for the Sequel II + Sequel IIe Systems. 👍 New primers, clean up & binding kits.🙌 New library prep protocol w/ 3x reduction in DNA input.💪 SMRTLink boost .
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Help poor @seemaychou get her mom - and half the @UCSFMedicine community? - off her back. Her lab would love to have the Pacific Tick genome sequenced. Agree? Vote here: #pacificusdreams.@ucsf_biochem @czbiohub
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Meet the Sequel System: SMRT Sequencing w/higher throughput (~7x more reads), lower project costs & reduced footprint http://t.co/o86MOltMgs.
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Given the state of the pandemic & for the safety of our attendees, staff, colleagues, clients & their communities, we will no longer be hosting/ livestreaming our in-person workshop at #PAGXXIX. We look forward to hosting our workshop in a safer environment virtually soon.
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Live now - keynote talks from #SMRTLeiden online! We're thrilled to share 20+ speakers from around the world presenting their research powered by SMRT Sequencing. Watch: @LUMC_Leiden @erichjarvis @hagentilgner @anaconesa @sergekoren @NEBiolabs @corteva
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This cheeky parrot is one of only 148 left in the wild & one of the first 15 genomes to be released by the @GenomeArk. Learn more about the #VGP project & the bird @takapodigs @Spokesbird #forJane @erichjarvis
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Two genomes from one cross-bred cattle, distinguishing maternal & paternal haplotypes? It's possible, thanks to a trio-binning method from @aphillippy @sergekoren @ArangRhie @tplsmith. Popular at #PAGXXVI, now in preprint & on our blog:
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Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome via @NatureBiotech. De novo genome assembly produced a contiguous and accurate genome with a contig N50 of >15 Mb & concordance of 99.997% #HiFiReads
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LATEST: We’ve always known that high quality, long reads begin with high quality HMW DNA 🧬. That’s why today’s news is so important:. #HiFiSequencing #DNAextraction #acquisition @circulomics
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Happy Friday! As a reward for getting through the week, we'd like to show you the amazing photography of @TimFlach . These two made us think of our friends at @genomeark and @bat1kgenomes. Enjoy, @erichjarvis & @Sonja_Vernes! #TGIF #naturerocks.
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With the release of the Sequel II System earlier this year, it is now affordable for scientists to access highly accurate long-read sequencing data. DYK we've added enhancements already? Find out more in a webinar w/ product guru Marty Badgett next Wed.
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Holy exquisite genomes Batman! The genetic basis of bats’ superpowers revealed in @nature by @bat1kgenomes. Congrats to @EmmaTeeling1 @Sonja_Vernes @hillermich & all involved. Proud to support the generation of high quality bat genomes w/PacBio sequencing:
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E is for evolution! The evolution of the new Sequel IIe System includes increased computational capacity & on-instrument data processing to directly produce highly coveted, highly accurate #HiFiReads -- saving users time & money. Learn more:
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Just like The Force, our genomes are both powerful and mysterious. Unleash the full potential of your research with #Onso and #Revio, and explore the dark regions of the genome. May the force of genomics be with you!. #MayThe4th #PacBio
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Is it possible to generate truly high-quality, long-read data from minuscule amounts of DNA? Absolutely, thanks to our new kit for ultra-low DNA input, which enables whole genome amplification starting from as little as 5 ng of genomic DNA.
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Start your year with a win: Bring in long reads, accuracy, uniform coverage, and native methylation calling – Revio system at ~50% less up front with reagent bundles. See the offer:
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How to improve the accuracy of #DeepVariant even further? Tackle phasing. See how the @GoogleHealth team improved their popular variant caller to make the most of #HiFiReads with a new haplotype channel.
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🌱 A complete de novo plant genome generation workflow that starts from plant tissue samples & produces high-quality draft genomes w/ relatively modest laboratory & bioinformatic resources. within 7 days? Check out #LeafGo by @kaust_corelabs 🌱.
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The results are in! Long-read sequencing named 2022 Method of the Year by @naturemethods. A win for our customers and the scientific community- let's keep the discoveries coming in 2023! #Revio #PacBio.
It's finally here!! Our Method of the Year 2022 is. long-read sequencing! 🎉. Read our (free!) Editorial to learn why we felt the time was right to select this class of powerful technologies as the Method of the Year.
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Best stuff is in the Supplement! HGSVC says 'As sequencing tech & assembly algorithms continue to evolve, HiFi sequencing has been predicted to predominate because accuracy & higher depth will afford access to even more previously inaccessible regions.'
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“The ability to find so many variants that were previously missed is exciting, + holds great promise for diagnostic testing in the future.” See what Greg Cooper & colleagues at @hudsonalpha found when they applied #HiFiReads to unsolved #raredisease cases.
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Extracting DNA for sequencing isn’t always as straightforward as lyse, precipitate, wash, suspend. In this #Sequencing101 blog, we share tips, tricks, & protocols to help make your DNA isolation easier. Check it out & share widely!
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Oxford, Liverpool, Edinburgh. and beyond! The UK is now well equipped for #SMRT Sequencing, w/ several new Sequel II & IIe Systems installed at three top centres: @OxfordGenomics @CGR_UoL @edgenome.We can't wait to see what discoveries they will enable!
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We look forward to seeing what @radboudumc can accomplish with their addition of 2 new #PacBio Sequel IIe Systems. Their work with our #SMRTsequencing is crucial in identifying hidden variants that cause #rarediseases. Learn more here: 📸: @ahoischen
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