📢Announcing the launch of our COVID-19 Collection. Covering original research, reviews & much more. Check it out now 👇#ClinTransImmunol #CTICOVIDCollection #SARSCoV2 #COVID19 #COVID_19 #Immunology #Openaccess @wileymolecular @khanna_rajiv @ASImmunology

Allogeneic SARS-CoV-2-specific T-cell therapy was safe and reduced viral load in most immunocompromised cancer patients with COVID-19 in a phase I trial. @WileyGlobal @ASImmunology .

Tattoo uveitis shares key inflammatory features with sarcoidosis but is antigenically distinct—highlighting CXCR5 downregulation and EMT signatures as hallmarks of active sterile granulomatous disease. @ASImmunology @WileyGlobal .

A new study shows semi-automated CAR T-cell manufacturing using Cellmation software delivers high-quality, functional cells—offering a scalable, efficient alternative to manual production. @ASImmunology @WileyGlobal .

Public scRNA-seq data are key to paediatric cancer research, but poor deposition standards hinder reuse. A review of >1.3M cells from 488 samples proposes a framework to improve practices. @ASImmunology @WileyGlobal.

Lower B cells and Tregs—seen before transplant—were linked to chronic lung allograft dysfunction, not donor-specific antibodies. High-dimensional flow cytometry reveals early immune clues. @WileyGlobal @ASImmunology .

In posterior uveitis, vitreous T cells—especially polyfunctional CD8+ cells—show distinct, antigen-specific responses not mirrored in blood, highlighting the limitations of PBMCs in reflecting ocular immunity. @ASImmunology @WileyGlobal .

T-cell responses to SARS-CoV-2 spike differ after vaccination vs. natural infection—vaccines focus on limited regions and HLA-A, while infection broadens epitope spread and shifts to HLA-B (esp. B7).@ASImmunology @WileyGlobal .

IgG aggravates TNF-α-mediated osteoclastogenesis by enhancing TNFR1/NF-κB signaling, helping explain the greater joint damage seen in RA compared to SLE. @ASImmunology @WileyGlobal .

Radiotherapy can boost T-cell responses and enhance immunotherapy, but clinical success remains limited—future research must address barriers and optimize combinations for better cancer outcomes.@ASImmunology @WileyGlobal .

Progressive loss and activation of MAIT cells correlate with worsening myocardial ischaemia and remodelling in CAD patients, possibly due to gut microbial leakage.@ASImmunology @WileyGlobal .

RT @ASImmunology: We warmly congratulate Dr Charis Teh - winner of the Margaret Baird Women in Immunology ASI Award!!.@WEHI_research #IWD25….

Long-term γδ T cell reconstitution after allogeneic stem cell transplantation shows a normalised repertoire, sustained CMV control, and increased activated Vδ1+ T cells in severe chronic GVHD.@ASImmunology @WileyGlobal .

MAIT cell activation profiles in the emergency department distinguish sepsis severity, with high CD69 expression linked to worse outcomes and cytokine-driven activation.@ASImmunology @WileyGlobal .

Lower dendritic cell levels in blood and airways predict severe COVID19, while monocytes accumulate in the lower airways. DC depletion persists in severe cases, but most immune responses recover post-infection.@ASImmunology @WileyGlobal .

CAR therapy faces challenges with high relapse rates (~60%), off-tumor toxicity, and immune deficits—organ-on-chip tech offers a promising alternative to animal models for real-time testing.@ASImmunology @WileyGlobal .

BCG induced a broad and persistent reduction in ex vivo cytokine responses to SARS-CoV-2 but had no impact on antibody or T-cell responses to COVID-19 vaccines. @ASImmunology @WileyGlobal .

Autoantibodies against CD209/CD209L are found in some COVID-19 patients but aren't linked to worse outcomes, unlike anti-ACE2 and anti-IFNα antibodies. @ASImmunology @WileyGlobal.

Off-the-shelf CD19-CAR double-negative T cells show promising efficacy, safety, and manufacturability for treating haematological malignancies, with no observed immunotoxicity or GVHD.@ASImmunology @WileyGlobal .

Incorporating non-criteria antibodies improves obstetric antiphospholipid syndrome diagnosis, identifying cases responsive to aspirin/heparin therapy despite low traditional aPL levels.@ASImmunology @WileyGlobal .

Type 2 epithelial cytokines and basophils play critical roles in allergic inflammation and immune responses, with recent FDA-approved biologics targeting these pathways offering new treatments for allergic diseases. @ASImmunology @WileyGlobal .