Clinical & Translational Immunology
@ClinTransImmuno
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Open access journal publishing cutting-edge advances in biomedical research for scientists and physicians. Official journal of @ASImmunology #ClinTransImmunol
Global
Joined March 2020
📢Announcing the launch of our COVID-19 Collection. Covering original research, reviews & much more. Check it out now 👇#ClinTransImmunol #CTICOVIDCollection #SARSCoV2 #COVID19 #COVID_19 #Immunology #Openaccess @wileymolecular @khanna_rajiv @ASImmunology
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New study reveals SIRT7 restores Th17/Treg balance in immune thrombocytopenia by desuccinylating STAT3—highlighting a novel epigenetic target for ITP therapy. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
In this study, we investigated the effect of SIRT7 on the balance of Th17/Treg in immune thrombocytopenia (ITP) and to elucidate the associated molecular pathways. We found that SIRT7 improves the...
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Engineered iPSC-derived NK cells are revolutionising cancer immunotherapy with scalable, off-the-shelf potential and enhanced tumour-killing power. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
This article describes the schematic of the workflow for iPSC-derived NK cells in immunotherapy. iPSCs, generated from somatic cells, undergo genetic modifications (e.g. CAR insertion and CRISPR...
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In t(8;21) AML, leukemic arrest at monocytic stages predicts poorer survival and higher relapse, highlighting differentiation stage as a key prognostic factor beyond genetics. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
In this multi-centre study of 338 t(8;21) acute myeloid leukaemia patients, we demonstrate that leukaemic arrest at monocytic differentiation stages (Immuno-Mono) predicts significantly worse 2-year...
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Combined maintenance with anti-PD-1 and capecitabine significantly improves progression-free survival in metastatic nasopharyngeal carcinoma, offering a promising strategy post-chemotherapy. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
This cohort study evaluated the therapeutic efficacy of combined immunochemotherapy maintenance with capecitabine and anti-PD-1 antibodies in metastatic nasopharyngeal carcinoma (NPC) patients....
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Post-COVID-19 patients show long-term immune alterations across cell types, with potential links to BCG vaccination and improved outcomes in COVID-19 and sepsis. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
This study examined long-term immune alterations in individuals who recovered from COVID-19 and explored potential links between Bacillus Calmette–Guérin (BCG) vaccination, latent infections and...
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Acute high-intensity exercise boosts circulating CD8+ T cells with enhanced cytotoxicity and metabolic rewiring, suggesting improved immune surveillance post-HIIT. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
In this study, we show that supramaximal high-intensity exercise induces a marked increase in the total number of circulating CD8+ T cells characterised by reduced glycolytic activity, a distinct...
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Trauma reshapes circulating dendritic cell and monocyte subsets, with distinct regulation of adhesion GPCRs EMR2, CD97, and EMR3 revealing diverse immune roles in injury response.@ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
We monitored various dendritic cell (DC) and monocyte subsets in traumatised patients for up to 240 h after injury, and compared them with uninjured volunteers who underwent the same blood sampling...
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RT @khanna_rajiv: Join us for celebration of 25 years of Brisbane Immunology Group (BIG). BIG-2025 retreat will be held at @seaworldresort….
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Allogeneic SARS-CoV-2-specific T-cell therapy was safe and reduced viral load in most immunocompromised cancer patients with COVID-19 in a phase I trial. @WileyGlobal @ASImmunology .
onlinelibrary.wiley.com
In this study, we conducted an open-label phase I trial to assess the feasibility and safety of allogeneic SARS-CoV-2 specific TÂ cells in immune-compromised cancer patients with COVID-19. Our...
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Tattoo uveitis shares key inflammatory features with sarcoidosis but is antigenically distinct—highlighting CXCR5 downregulation and EMT signatures as hallmarks of active sterile granulomatous disease. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
Tattoo uveitis (TU) resembles sarcoidosis but is distinguished by the absence of systemic lymphadenopathy despite inflammation of skin and eyes. In this study, we compared blood-borne signatures of...
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A new study shows semi-automated CAR T-cell manufacturing using Cellmation software delivers high-quality, functional cells—offering a scalable, efficient alternative to manual production. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
We present an end-to-end methodology for semi-automating the cell therapy manufacturing workflow using CTS Cellmation software – an off-the-shelf software solution – to control physically connected...
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Public scRNA-seq data are key to paediatric cancer research, but poor deposition standards hinder reuse. A review of >1.3M cells from 488 samples proposes a framework to improve practices. @ASImmunology @WileyGlobal.
onlinelibrary.wiley.com
Publicly available scRNA-seq data can support new research ideas, especially in resource-limited settings, but the lack of standards complicates data validation and analysis. In this article, we...
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Lower B cells and Tregs—seen before transplant—were linked to chronic lung allograft dysfunction, not donor-specific antibodies. High-dimensional flow cytometry reveals early immune clues. @WileyGlobal @ASImmunology .
onlinelibrary.wiley.com
Using high-dimensional flow cytometry, we describe in detail the temporal lymphocyte biology that accompanies LTx and identify a putative novel signature that may predict the subsequent development...
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In posterior uveitis, vitreous T cells—especially polyfunctional CD8+ cells—show distinct, antigen-specific responses not mirrored in blood, highlighting the limitations of PBMCs in reflecting ocular immunity. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
In this article, we compare the T-cell profiles and antigen-specific cytokine responses between paired vitreous and peripheral blood samples from patients with sight-threatening uveitis. The vitreo...
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T-cell responses to SARS-CoV-2 spike differ after vaccination vs. natural infection—vaccines focus on limited regions and HLA-A, while infection broadens epitope spread and shifts to HLA-B (esp. B7).@ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
We investigated the immunoreactivity of SARS-CoV-2 spike protein T-cell epitopes in individuals who were SARS-CoV-2 naive, vaccinated with the AstraZeneca vaccine, and those who became naturally...
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IgG aggravates TNF-α-mediated osteoclastogenesis by enhancing TNFR1/NF-κB signaling, helping explain the greater joint damage seen in RA compared to SLE. @ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
This study uncovered a previously unrecognised dual role of IgG in osteoclastogenesis: while it suppressed receptor activator of nuclear factor kappa-B ligand (RANKL)-dependent osteoclast formation,...
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Radiotherapy can boost T-cell responses and enhance immunotherapy, but clinical success remains limited—future research must address barriers and optimize combinations for better cancer outcomes.@ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
While immune checkpoint inhibitors have shown remarkable success in solid tumours, the induction of TÂ cell dysfunction limits their effectiveness, resulting in treatment resistance and relapse. This...
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Progressive loss and activation of MAIT cells correlate with worsening myocardial ischaemia and remodelling in CAD patients, possibly due to gut microbial leakage.@ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
In this study, we found that as coronary artery disease (CAD) progresses, circulating mucosal-associated invariant T (MAIT) cells undergo a reduction in number, accompanied by increased activation...
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RT @ASImmunology: We warmly congratulate Dr Charis Teh - winner of the Margaret Baird Women in Immunology ASI Award!!.@WEHI_research #IWD25….
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Long-term γδ T cell reconstitution after allogeneic stem cell transplantation shows a normalised repertoire, sustained CMV control, and increased activated Vδ1+ T cells in severe chronic GVHD.@ASImmunology @WileyGlobal .
onlinelibrary.wiley.com
In this study, we found that long-term γδ T cell reconstitution post allogeneic haematopoietic stem transplantation (aHCT) reached a homeostatic state with a normalised TRG CDR3 repertoire. Importa...
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