My son had the best time at Flagg @ProCamps basketball camp! Watching Cooper, Ace & Hunter 2v2 on the court was hilarious & grounding. At the end of the day, the kids took away important lessons - work hard, have fun, love your family & be grateful! @Cooper_Flagg @kflagg11

Link to Katherine's paper:

Join millions who have switched to Grok.

We had the honor to preview @TheKingLab's new publication in @CellStemCell; 'Plot Twist: TET2 Clones Save the Brain'. If you are interested in peripheral vs. central immune cells in the brain in health and disease, check it out!

This was so much fun! Great Q&A and trainee dialogue fueled by pure sugar 😁.

The annual Trowbridge lab mini golf tourney! Newest lab members are team captains & pick their team & theme. Thanks to Margaret, Natalie & Kayla we had team Goldilocks, team pro golfers & team goth. As you likely guessed, the pro golfers won! 🏆 Always a blast with this crew!

Delighted to share an updated review and our perspectives on clonal hematopoiesis and cancer in @NatureCancer in collaboration with Xiurong Cai and Bobby Bowman:

Grants submitted, paper submitted, experiments on pause. taking a break and getting out into our backyard National park! E-bikes for the win 🙌

RT @Fusion_Conf: Day 2 of #MyeloidMalignancies25 is underway. We have more exciting talks after lunch & the poster session later this eve….

A fantastic meeting in the beautiful location of Crete!!.

It is the best feeling when a former trainee surprises you by being in the audience for your talk. and THEN you take that opportunity to shout out the foundational contributions that they have made to your lab and to the field!! @LobergMatthew was and is an absolute rockstar!.

Looking forward to speaking at this symposium and hearing about fantastic new work by @SignerLab Stephnie Xie & James DeGregori! #AACR25.

RT @FASEBorg: For 30 years, #HEMSRC has brought together researchers of hematologic malignancies to share their work at the leading edge of….

RT @jacksonlab: Now published in @NatureComms, JAX scientist Jennifer Trowbridge and team (@TrowbridgeLab) uncovered that supercharged mito….

Congrats to Kira Young who spearheaded this work & all contributing authors. This was a fun (and long!) collaboration with Marc Mansour, Grant Challen, Eric Pietras, Kelsey Fisher-Wellman, @The_Ito_Lab & Steven Chan. Supported by @NIH, EvansMDS & @LLSusa .

To me, one of the coolest things about these papers is that three different labs in three different countries (US, Canada, UK) INDEPENDENTLY observed the same foundational phenotype of increased mitochondrial OXPHOS in Dnmt3a-mutant hematopoietic stem & progenitor cells 🇨🇦🇬🇧🇺🇸.

Together, we report that mitochondrial activity is a targetable mechanism by which clonal hematopoiesis-mutant HSCs gain a selective advantage over wild-type HSCs.

We find that MitoQ also targets elevated mitochondrial respiration and the selective advantage of human DNMT3A-mutant HSCs, supporting species conservation.

Exploiting elevated mitochondrial membrane potential, we used long-chain alkyl-TPP molecules (ex. MitoQ) that selectively accumulate in the mitochondria. These caused reduced mitochondrial respiration, apoptosis, and ablated the competitive advantage of Dnmt3a-mutant HSCs.

Dnmt3a-mutant HSCs have DNA hypomethylation and increased expression of oxidative phosphorylation gene signatures, increased functional OXPHOS capacity, high.mitochondrial membrane potential & greater dependence on mitochondrial respiration versus wild-type HSCs.

Using a mouse model of Dnmt3a-mutant CH that our lab previously developed, we found that mutant HSCs sustain elevated mitochondrial respiration which is associated with their resistance to aging-induced changes in the bone marrow microenvironment.