Congratulations to the authors on this terrific piece of work! Read the original work here:

I had the opportunity to write an editorial for a piece in Neuro-Oncology (@NeuroOnc ) executing a genomic analysis on perhaps the largest cohort of extracranial metastases of adult gliomas to date.

Why does the telomere interact with these distant repeats? We speculate that this is key for maintaining nuclear organization and may involve nuclear orphan receptors. Many questions remain. Read the paper to dive into the data 👇 #TelomereC #Genomics #Chromatin #Epigenetics

We validated these contacts with classic 3C/PCR and confirmed the 3D proximity using Southern Blotting and stunning 3D FISH data, proving these are real, higher-order chromatin structures.

Specifically, we found strong enrichment at three classes of repetitive elements: Interstitial Telomeric Sequences (ITS), Telomere-Associated Repeat 1 (TAR1), and D20S16 elements.

The telomeric interactome spans the entire genome! While contacts are enriched near telomeres (<100 Kb), over 80% of all interactions occurred >5 Mb away from chromosome ends. This isn't just about the subtelomere.

Our initial goal was to map telomeric regulation of key genes, like TERT. The reality? Gene-level interactions were massively outnumbered by contacts with repetitive elements! 🤯

To map the telomeric interactome, we developed Telomere-C (Telomere Conformation Capture). This novel, ligation-free method uses a biotinylated PNA probe to capture telomeric DNA, allowing us to measure nuclear contacts efficiently using short-read sequencing.

Excited to share our preprint (3rd of 2025) on the 3D telomeric interactome, a project that started with a K99 in 2018. Thanks to @YA_Chen_PhD, first postdoc in our lab and first author who worked tirelessly to realize this dream.

Happy to get this one out at last. Might have to do a little thread on this later.

Massive credit to the brilliant PhD student @SharvariMankame, for leading this work. You can dive deeper into the science with our full thread on the other platform. #Glioblastoma #cfDNA #TGen #Research

Excited to share our new preprint: "Cell-Free DNA Sequencing Uncovers the Longitudinal Consequences of Temozolomide Treatment and Host Co-Culture in Glioblastoma"! https://t.co/eyzixOEHoS

Two weeks ago we shared our lab's first manuscript on bioRxiv: https://t.co/53RIq5Fcm0 We performed diploid genome assembly to fully resolve the telomeres, centromeres and numerous other repeats of the BJ and IMR-90 fibroblast cell lines. Please get in touch with feedback!

I roughly calculated the state-level economic impact of withholding NIH grants in terms of jobs lost per day. For Missouri it's 79--553 jobs a week that this drags on. Data: https://t.co/PJyjsAcwWK How to contact your representatives with this information:

Investigating structural variants? I just released a tutorial video showing how I do this quickly and intuitively using my tools Ribbon and SplitThreader: https://t.co/AlF0gR17kA

A comprehensive survey of RNA modifications in a human transcriptome https://t.co/GepqiRyqUv #biorxiv_genomic

In https://t.co/TpdlGQ2Nwv, @rayarayan, Yoann Dufresne and I comment on the decoupling of ‘population’ pangenome graphs from ‘application-specific’ pangenome graphs. (1/3)

Let me introduce Transipedia, our project for cancer RNA-seq exploration just published in Genome Biology, with @ChloeBessiere, @CamilleMrcht, @RayanChikhi, @hl_xue, M. Salson and Thérèse Commes’ lab in Montpellier. 1/9 👇 https://t.co/A8SmVgp8hG

Prestige signals and pedigree are anathema to the scientific endeavor and quite harmful to the community of scientists actively working to advance human knowledge.