Floris Barthel
@florisbarthel
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Assistant professor @TGen | Postdoc @jacksonlab @MDAndersonNews | Evolutionary cancer genomics | Glioma | Telomere dysfunction | Tweets are my own
Phoenix, AZ
Joined November 2009
Massive credit to the brilliant PhD student @SharvariMankame, for leading this work. You can dive deeper into the science with our full thread on the other platform. #Glioblastoma #cfDNA #TGen #Research.
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Excited to share our new preprint: "Cell-Free DNA Sequencing Uncovers the Longitudinal Consequences of Temozolomide Treatment and Host Co-Culture in Glioblastoma"!.
biorxiv.org
Glioblastoma (GBM) is a highly aggressive brain tumor with limited options for longitudinal monitoring. We evaluated the potential of cell-free DNA (cfDNA) as a real-time biomarker of tumor burden...
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Two weeks ago we shared our lab's first manuscript on bioRxiv: We performed diploid genome assembly to fully resolve the telomeres, centromeres and numerous other repeats of the BJ and IMR-90 fibroblast cell lines. Please get in touch with feedback!.
biorxiv.org
Human cell lines are fundamental tools in biomedical research and are widely used in disease modeling, drug development, and many other domains. Here, we present chromosome-level, phased diploid...
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RT @mpmeers: I roughly calculated the state-level economic impact of withholding NIH grants in terms of jobs lost per day. For Missouri it'….
usa.gov
Use USAGov’s Contact Your Elected Officials tool to get contact information for your members of Congress, the president, and state and local officials.
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RT @marianattestad: Investigating structural variants? I just released a tutorial video showing how I do this quickly and intuitively using….
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RT @biorxiv_genomic: A comprehensive survey of RNA modifications in a human transcriptome #biorxiv_genomic.
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RT @pashadag: In @rayarayan, Yoann Dufresne and I comment on the decoupling of ‘population’ pangenome graphs from….
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RT @DGautheret: Let me introduce Transipedia, our project for cancer RNA-seq exploration just published in Genome Biology, with @ChloeBess….
link.springer.com
Indexing techniques relying on k-mers have proven effective in searching for RNA sequences across thousands of RNA-seq libraries, but without enabling direct RNA quantification. We show here that...
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RT @nomad421: Prestige signals and pedigree are anathema to the scientific endeavor and quite harmful to the community of scientists active….
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RT @NeBanovich: Excited to be launching COSMO. If you are looking to generate spatial transcriptomics data please reach out!.
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RT @StevenSalzberg1: pretty cool result: using a new mathematical model, scientists estimate that the ancestral human population shrunk to….
science.org
A severe bottleneck that brought human ancestors close to extinction occurred between about 930 and 813 thousand years ago.
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RT @kunhsingyu: Excited to share that our paper on a foundation AI model for cancer prognosis and pathology diagnosis is published in Natur….
nature.com
Nature - A study describes the development of a generalizable foundation machine learning framework to extract pathology imaging features for cancer diagnosis and prognosis prediction.
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RT @KathleenHBurns: Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesis .
biorxiv.org
L1 retrotransposition is a significant source of genomic variation in human epithelial tumours, which can contribute to tumorigenesis. However, fundamental questions about the causes and consequences...
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Stellar discussions and even better company.
We spent two days in the mountains discussing how cancer genomes become such a chaotic and rearranged mess. Thanks to the participants, my fellow co-organizers @isidrolauscher and Titia de Lange, and @ForbeckForums for bringing us together in Aspen, Colorado!
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This is pretty incredible - and the future of our field.
Today we’re excited to freely share an early-version of, perhaps, the world’s most expansive genetics dataset: Logan. #bioinformatics #petabase #genetics #genomics #openscience.
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RT @ewanbirney: Some muses on data engineering. TL;DR much of science is happening in a computer, not least AI. This is often called "Data….
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RT @megankle: I'm happy to share the results of my rotation with @lh3lh3: We co-assembled reads from paired tumor-….
biorxiv.org
The accurate identification of somatic structural variants (SVs) is a problem with significant applications to clinical cancer research. Though technologies such as long-read sequencing have facili...
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This is a fantastic piece of journalism that rings very close to home yet it's message perhaps even extends beyond the scope intended by Packer.
Civilization in Phoenix and its surrounding valley depends on solving the problem of water. Solving the problem of water depends on solving the problem of democracy. In The Atlantic’s latest cover story, George Packer explores if America is up to the task.
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RT @mpmeers: All researchers who engage with NIH should read these recommendations carefully and submit comments by the August 16th deadlin….
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