The Mark Foundation for Cancer Research
@TheMarkFdn
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Partnering with scientists to accelerate transformation in cancer research
New York, NY
Joined May 2017
“The Mark Foundation is different from other organizations. All types of cancer are in scope for us, and that was by design, from the beginning.”—Ryan Schoenfeld, CEO Watch our new video to learn how we are accelerating progress in the fight against cancer.
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A major leap in antibody design! Members of CGC #NexTGen (co-funded by @TheMarkFdn), Nikolaos Sgourakis & John Maris, contributed to a new Nature paper from David Baker’s lab showing AI-designed antibodies with atomic-level precision. A potential game-changer for how we discover
nature.com
Nature - The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that...
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We’re in Bergamo, Italy, for @EACRnews-Mark Foundation Joint Conference: The Rise of Early-Onset Cancers! For 3 days, experts from diverse fields are exploring the alarming rise of cancer in young patients & identifying new strategies for prevention, detection, & treatment.
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Huge quarter for our grantees! Q3 2025 papers reveal links between dietary fat & cancer (@lynchielydia), humoral determinants of checkpoint blockade (@aaronmring), and mechanisms for cachexia (@AyeletErez).🔬Check out our full list of highlights: https://t.co/0R6xHcKBOv
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💡 New research from the #CancerGrandChallenges NexTGen team offers a way to make CAR T-cell therapy more effective — even against cancers that try to hide. This study is part of the NexTGen project, supported by @CR_UK, the @theNCI, and @TheMarkFdn through the Cancer Grand
nature.com
Nature Cancer - Majzner and colleagues show that engineering T cells with a membrane-tethered version of the signaling adaptor molecule SLP-76 alongside a chimeric antigen receptor (CAR) enhances...
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Through data sharing and methods refinement, these two groups are working collaboratively to identify correlates for predicting early progression or transformation in FL. Learn more about their work & our partnership with @Cure_FL:
themarkfoundation.org
The Mark Foundation for Cancer Research and the Follicular Lymphoma Foundation have joined forces to co-fund two new ASPIRE Awards focused on developing more personalized treatment strategies for...
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Both teams are making exciting progress toward the goal of using novel spatial omics platforms and AI-guided approaches applied to a collection of longitudinal tissues to map the FL microenvironment.
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Last week, we traveled to NOLA to hear updates from two fantastic ASPIRE Award teams co-funded by our partners at @Cure_FL and led by Michael Green (@GreenLymphoLab) & Rong Fan (@RongFan8).
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We're so grateful to our partners at @TheMarkFdn for supporting the NexTGen team and helping to make their research possible. “For far too many children living with these types of cancer, current treatments are not good enough. We’re proud to support this ambitious global effort
📢 Congratulations to our NexTGen team who have been featured in the @washingtonpost discussing their CAR T-cell immunotherapy trial. This landmark study will explore whether CAR T-cell therapy can offer new hope for children and young people with hard-to-treat solid tumours —
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It was a fun update and brainstorming session on how to best tackle inflammatory drivers of the obesity-cancer connection. The science is great and the team is even better
Fantastic meeting in sunny Chicago with our trainees and investigators across sites to share recent updates in person with our @TheMarkFdn Endeavor Award team. Thanks to @JeffRathmell for hosting us at @UChicago in the beautiful Knapp Center for Biomedical Discovery.
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The @AACR–Mark Foundation Chemistry in Cancer Research Grants are now accepting Letters of Intent! We’re seeking bold, innovative approaches in chemistry and chemical biology to tackle the biggest challenges in cancer. Apply now➡️ https://t.co/rrXs3leSN7
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Fantastic meeting in sunny Chicago with our trainees and investigators across sites to share recent updates in person with our @TheMarkFdn Endeavor Award team. Thanks to @JeffRathmell for hosting us at @UChicago in the beautiful Knapp Center for Biomedical Discovery.
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In her keynote at last year’s Mark Foundation Scientific Symposium, Regina shared her insights into how BoltzGen and AI will open radical new possibilities for drug discovery, & we’re proud to support this work through the @CancerGrand Challenges MATCHMAKERS team.
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Molecular modeling has just leveled up! 🤖 BoltzGen, a new generative model created by Mark Foundation grantee @BarzilayRegina & her colleagues at @AIHealthMIT, can generate new protein binders against any biomolecular target. https://t.co/5ZymOutADZ
boltz.bio
BoltzGen is a new generative model for designing protein and peptides of any modality to bind a wide range of biomolecular targets.
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📣 CAR T breakthrough! In @Nature, @CancerGrand’s MFCR-supported team NexTgen demonstrates a new method to amplify signaling in CAR T therapy to overcome a key cause of resistance. https://t.co/BYvYSdRln8
#CancerResearch #CancerImmunology
nature.com
Nature Cancer - Majzner and colleagues show that engineering T cells with a membrane-tethered version of the signaling adaptor molecule SLP-76 alongside a chimeric antigen receptor (CAR) enhances...
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Help us build a figure of healthier aging by supporting the Waxman Institute:
themarkfoundation.org
Your support of the Samuel Waxman Institute for Aging & Cancer, a subsidiary of the Mark Foundation, will allow us to accelerate scientific discovery and build a future of healthier aging.
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This Wednesday, we celebrated @WaxmanCancer's legacy - and its future as the Samuel Waxman Institute for Aging & Cancer at The Mark Foundation - at its 28th annual "Collaborating for a Cure" celebration. Together, 200 attendees raised $1.6 million for cancer research!
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Great feature from @DanaFarberNews on exciting new research by 2019 Emerging Leader Award winner @CKadoch!
New research in @NatureGenet from @DanaFarber’s @CKadoch and @Jstlaurent_MD uncovers potential targeted therapy for endometrial cancer. @kadochlab ➡️ https://t.co/34LHIke5XF
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🎉Three members of The Mark Foundation’s community — @CharlesSwanton, Michel Sadelin, and Victor Velculescu — were elected to @theNAMedicine yesterday! 🎉 Learn more about their remarkable achievements:
themarkfoundation.org
Yesterday, the National Academy of Medicine announced the election of 90 new regular members and 10 international members in recognition of their outstanding professional achievement and commitment...
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✨✨hot off the press from the #loilab. We show here that pregnancy & breastfeeding is associated with increased T cells in the normal breast and protection against #tnbc #breastcancer moving the role of immunity from treatment to prevention. 👏👏Thanks to @FAndreMD @DrChoueiri
Translational data shows that #breastfeeding helps personal immunity improving CD8+ T This work can help to understand better the immune system and breastfeeding mechanisms @LoiSher @OncoAlert #ESMO25 @FernandoOnco
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“These kinds of game-changing results can only come from a unified, global approach to cancer research that is not limited by geography. That’s why we remain committed to funding the most innovative science, wherever it takes place.” - Ryan Schoenfeld, PhD, CEO of @TheMarkFdn
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