Jay Shendure
@JShendure
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Genomics technology developer. Developmental biology adult learner. Professor at @uwgenome @HHMINEWS @BrotmanBaty. He/him.
Seattle, WA
Joined May 2011
Today we release in @biorxivpreprint a pair of related methods, DNA Ticker Tape & ENGRAM, for multiplex, temporally ordered genomic recording of cell lineage histories, enhancer & signal transduction activities, respectively led by the brilliant @_Choi_Junhong & @wchenomics 1/25
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RT @SomiteAi: Somite is building the blueprints to create any cell type for any person. We call it DeltaStem, our foundation model for the….
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RT @ShechnerLab: Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!). O-MAP is a powerful new method for biochemicall….
nature.com
Nature Methods - Oligonucleotide-mediated proximity-interactome MAPping (O-MAP) enables precise multiomic characterization of biomolecular interaction networks at target RNAs. Distinct O-MAP...
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RT @loicaroyer: 🚨Big news! Five years in the making, our Zebrahub paper is now published in #Cell 🎉. We’ve built a timecourse atlas of zebr….
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RT @Yi__Fu: Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells an….
biorxiv.org
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled the precise introduction of base substitutions and the effective removal of genomes carrying harmful...
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RT @JCoolScience: Flexible differential expression analyses have always been neat in CZ #CellxGene. Now they’re next level! Quickly perform….
cellxgene.cziscience.com
Find, download, and visually explore curated and standardized single cell datasets.
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RT @sdomcke: New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for exam….
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RT @jvveenvliet: 📢 Check out our @teamstembryo @NatureCellBio News & Views with postdoc @alex_schauer_ on the latest feat in human stem-ce….
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RT @UW: University of Washington biochemist David Baker has won the 2024 Nobel Prize in Chemistry for his pioneering work designing new pro….
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RT @NobelPrize: BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to….
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RT @TroyMcDiarmid: Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineer….
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RT @diegoisworking: Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Caldero….
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RT @DougJBalloon: (1/X) I hate doing these, but I feel like I'm being baited to do so. A few days ago Maggie H did an interview where she….
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RT @TroyMcDiarmid: Our paper describing a scalable method for Multiplex, single cell CRISPRa screening for cell-type specific regulatory el….
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RT @FloChardon: Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to i….
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RT @jeffnivala: Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing C….
nature.com
Nature - A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed...
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RT @NatureCellBio: 💫NEW: Hamazaki, Yang et al. report that an early pulse of #RetinoicAcid induces human #gastruloids with a neural tube, s….
nature.com
Nature Cell Biology - Hamazaki, Yang et al. report that an early pulse of retinoic acid robustly induces human gastruloids with a neural tube, segmented somites and more advanced cell types than...
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RT @AMartinezArias: Deluge of useful information @ proteomics, protein/mRNA correlations, comparative molecular landscapes and more. #gastr….
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RT @riddhimankg: Very happy to share our latest w/ @dschweppe1 and @Nobu_Hamazaki labs, where we map the temporal dynamics and proteomic la….
biorxiv.org
Gastrulation is the highly coordinated process by which the early embryo breaks symmetry, establishes germ layers and a body plan, and sets the stage for organogenesis. As early mammalian development...
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RT @KircherLab: We are recruiting two computational biologists/bioinformaticians with ML expertise and a focus on genomics, variant effects….
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RT @ljljolin: Excited to share my postdoc work from the @schierlab. This project was a joint effort with many collaborators @seeliglab, @c….
biorxiv.org
The interplay between transcription factors and chromatin accessibility regulates cell type diversification during vertebrate embryogenesis. To systematically decipher the gene regulatory logic...
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