Junhong Choi
@_Choi_Junhong
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PI at @MSKCancerCenter. Synthetic (Developmental) Biology + Molecular recording. Words like the physicality of information make my heart go a bit faster.
Joined June 2020
New synthetic biology / molecular recording lab opening in the New York city, and we are hiring at all levels (research tech / grad student / postdoc), so please reach out to me via choij10 _at_ .
mskcc.org
At MSK, cancer care – from immunotherapy and surgery to integrative medicine – is the only thing we do. Call us at 800-525-2225, visit us online at MSKCC.org, or in person at 1275 York Avenue, New...
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RT @junyue_cao: Finally out in @ScienceMagazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes acro….
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Amazing thread by @NatureRevGenet on our review paper! Thoroughly enjoyed being a part of this group :-) (+@wchenomics, missed in the original post).
The lives of cells, recorded #Perspective by @AskaryLab, Wei Chen, @_Choi_Junhong, Lucia Y. Du, @ElowitzLab, @james_gagnon, @schierlab, @sophieseid, @JShendure, @TanjaStadler_CH & @tranmartink.
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RT @sdomcke: New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for exam….
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RT @diegoisworking: Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Caldero….
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RT @TroyMcDiarmid: Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineer….
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RT @jsschiffman: Excited to share "Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution",….
nature.com
Nature Genetics - Phylogenetic analysis of trait heritability (PATH) applies phylogenetic correlations to single-cell lineage tracing data, quantifying cell state plasticity and transition...
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RT @GSKGradSchool: Now accepting applications for our 2025 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers wi….
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RT @SRsrivatsan: Today out in @biorxivpreprint we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial ge….
biorxiv.org
Spatial genomic technologies include imaging- and sequencing-based methods ( [1][1]–[3][2] ). An emerging subcategory of sequencing-based methods relies on a surface coated with coordinate-associated...
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RT @junyue_cao: Thrilled to introduce IRISeq, a scalable, cost-effective and imaging-free spatial genomic technique for mapping mammalian b….
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RT @Nobu_Hamazaki: Excited to share our human RA-gastruloid model in @NatureCellBio! Early retinoic acid supplementation, followed by later….
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With these two techs, I imagine we will see more advances in the molecular recording field, certainly from the SeaHub directed by @JShendure and hopefully from my lab at @MSKCancerCenter!.
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The revised ENGRAM paper is out! It was amazing to work with @willchemonics. During COVID, we were kicked out of the lab, and were only dreaming of making both ENGRAM and DNA Typewriter a reality :-).
Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously.
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RT @JShendure: Our latest, from the brilliant @wchenomics and @_Choi_Junhong, out in @Nature , is ENGRAM, a multiplex method for symbolic r….
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Our DNA Typewriter protocol (written by @LiaoHanna, @JShendure, and myself) is out! Thank you @NatureProtocols for writing/editing this with us and having it as this week’s #FeaturedProtocol :-).
#FeaturedProtocol this week from Jay Shendure on using #DNATypewriter (#primeediting-based method) for tracing insertional events
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RT @lydfinley: Our newest preprint identifies a role for p53 in balancing nutrient supply and demand by enabling phospholipid headgroup rec….
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RT @TommyVierbuchen: Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell….
biorxiv.org
The directed differentiation of pluripotent stem cells (PSCs) from panels of genetically diverse individuals is emerging as a powerful experimental system for characterizing the impact of natural...
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Lastly, I would like to thank my mentors (@JShendure and @puglisilab ) and friends in science (too many to list here!) who shaped my way leading up to here – Again, thank you!.
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Our lab ( is a part of the Developmental Biology Program in @MSKCancerCenter, with world-leading experts in Dev Bio, Cancer Bio, Genomics, and more. Exciting collaborations on their way :-).
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My lab will focus on developing new CRISPR Prime Editing-based DNA recording technologies (e.g., DNA Typewriter, ENGRAM, P3 editing) and applying them to understand Dev Bio + stem-cell models.
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