Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳

Online Now: Combinatorial mapping of E3 ubiquitin ligases to their target substrates https://t.co/T4aPvUHn08

Please re-tweet: We are hiring! Assistant Professor in statistical genetics. Also, hiring a postdoc. Reach out to hear more. Also, if you’ll be at #ASHG24 #ASHG2024, we could meet.

Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells and our exploration of how cellular metabolism and transcription respond to deletion heteroplasmy. https://t.co/yK2ns3YpiJ 1/19

New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4

This is happening tomorrow! Still some time to sign up! Both in-person and online opportunities! https://t.co/l1FpnlYB3j

Thinking about a PhD using computational power to answer pressing problems in biology and health? @UCSF Biological and Medical Informatics PhD program is recruiting for Fall 2025! Join our info session next Monday Oct 21: https://t.co/jLMUwigeI1.

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? https://t.co/l7bwPsTSkd (1)

The VESS organizing committee is looking for new members! If you are navigating the universe of variant effects and would like to get involved with @varianteffects seminars, contact us!

Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” ! https://t.co/8BtGh7th6P

Finally, starting a lab is chaotic, but it’s been an absolute joy because of my awesome colleagues @UCSF_BTS, and we’re looking to hire another PI this year! If you have bold ideas and are a great colleague, I encourage you to apply!

Before wrapping up, I want to encourage anyone considering applying for faculty positions to reach out! No two paths are the same, but If it’s helpful, I’d be happy to send application feedback or set up a Zoom to answer any questions about the process.

This position was the culmination of a long journey. Faculty hiring cycles are intense, but I loved visiting Universities + meeting so many inspiring scientists along the way. I landed @UCSF, but there are many terrific places to do science, making me optimistic about the future!

I’m eternally appreciative of the encouragement and support from my family and friends who have kept me going, especially through the lows. To them, I apologize for endlessly talking science – pushing them almost past the limits of their superhuman patience.

Getting to this point took a village of support over the years. I’m incredibly grateful for my mentors @JShendure @coletrapnell @jkpritch. I was fortunate to work with the most fantastic labmates, who taught me nearly everything I know.

The Calderon Lab will study how genetics impact health + disease with new computational + experimental techniques. To start, we’ll use data from MPRAs and sc-assays to train models of gene regulation that can, in turn, teach us how cells work (or don’t in disease).

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Human prehistory [separate thread] 3.4: Ancient DNA: a genetic time capsule [this thread] https://t.co/GHMPCTv6BL

We are thrilled to announce two open rank faculty searches @UofUGenetics: a broad search for all areas of genetics research ( https://t.co/fz3fKZYalB) & one focused on computational genomics faculty ( https://t.co/74HmsEUTna). This launches a multi-year recruiting initiative! (1/4)