Today we release in @biorxivpreprint a pair of related methods, DNA Ticker Tape & ENGRAM, for multiplex, temporally ordered genomic recording of cell lineage histories, enhancer & signal transduction activities, respectively led by the brilliant @_Choi_Junhong & @wchenomics 1/25

Super excited re: first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to brilliant Chase Suiter & @Green_Ahn @UWproteindesign on the work! Preprint: https://t.co/7gh8ZtcKUO

New paper from my lab and @JShendure lab! Led by the brilliant @Zukailiu and @CXchengxiangQIU. We tackle a question: How do anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid)? (1/n) https://t.co/PjZ7ZpuhOV

Thrilled at the news of @10xGenomics ' acquisition of @scalebio, which I co-founded with Frank Steemers (ex-Illumina), @coletrapnell and @GarryPNolan. Further thrilled to joining 10X Genomics as an scientific advisor and for the synergies that lie ahead!

This acquisition will bring together two pioneering companies with a shared vision: to make single cell analysis more powerful, affordable and accessible to researchers worldwide. Learn more: https://t.co/rtqbg7lFOa

Thank you @JShendure, @sapazz, Nicole Fraenkel @khoslaventures, @fidjissimo, @nasdaily, @NoamSolomon1, Kendra Harris, Katia Veressen, and Cliff Tabin for the video blessings. Thank you for helping us turn #AI insights into real therapies. #SomiteTherapeutics

Ideas aren’t just born fully mature into commercial realization. They require refinement, testing, well-integrated teams, and, moreover, a need for their purpose. I am thrilled, therefore, to announce the acquisition of Scale Biosciences by 10X Genomics. I co-founded Scale Bio

Somite is building the blueprints to create any cell type for any person. We call it DeltaStem, our foundation model for the human cell. Our proprietary capsule technology allows us to generate cell signaling data 1,000x faster and more efficiently than current methods,

Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 https://t.co/gBGsQ6dBs9

🚨Big news! Five years in the making, our Zebrahub paper is now published in #Cell 🎉. We’ve built a timecourse atlas of zebrafish embryonic development, combining #scRNAseq data and #lightsheet live imaging, and delved deep into the dynamics of key progenitors.

Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells and our exploration of how cellular metabolism and transcription respond to deletion heteroplasmy. https://t.co/yK2ns3YpiJ 1/19

Flexible differential expression analyses have always been neat in CZ #CellxGene. Now they’re next level! Quickly perform DE analysis across our entire data corpus. For ex: leveraging >125 relevant datasets to compare astrocytes with/without Alzheimer’s📷

New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4

📢 Check out our @teamstembryo @NatureCellBio News & Views with postdoc @alex_schauer_ on the latest feat in human stem-cell-based embryo models by @Nobu_Hamazaki, @JShendure & colleagues. Full text: https://t.co/793rz6GTD0 https://t.co/MrjeHBj0FV #gastruloids

University of Washington biochemist David Baker has won the 2024 Nobel Prize in Chemistry for his pioneering work designing new proteins that can neutralize viruses, target cancer cells, and more. Read more from @uwmedicine: https://t.co/PU7AM1ETvA #NobelPrize #GoHuskies

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” ! https://t.co/8BtGh7th6P

Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳

(1/X) I hate doing these, but I feel like I'm being baited to do so. A few days ago Maggie H did an interview where she complained criticism of her reporting, James Fallows answered back (mentioning this account) and Jon Chait and some Reason bro took a shot at Fallows for...

Our paper describing a scalable method for Multiplex, single cell CRISPRa screening for cell-type specific regulatory elements is now published! https://t.co/XSq2c5rPY8 https://t.co/ENt5kQ3zJz

Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to identify cell type specific regulatory elements is published!