Will Chen
@wchenomics
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@DamonRunyon Fellow at Baker lab @UWproteindesign. PhD with @JShendure. mainly at https://t.co/WpSk6RTizP
Seattle, WA
Joined October 2013
Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously.
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Molecular recording is an emerging field with exciting applications. In this review, @_Choi_Junhong and I outline major challenges that the community should address to fully realize the potential of this technology, and highlight promising directions that we are heading.
Molecular circuits for genomic recording of cellular events
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Beautiful work! congrats @yodai_takei !.
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies!
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Congrats @JONA. such beautiful paper.
I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine!. @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute. Lots of changes from the preprint. A🧵
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Congrats on this beautiful paper! @sudpinglay.
Now out in @ScienceMagazine we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.
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RT @junyue_cao: Finally out in @ScienceMagazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes acro….
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@tranmartink clarify: the editorial team made the final figures based on the amazing figures made by the above two.
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Such an enjoyable journey to write this review with all the amazing scientists. glad to see it's finally out. A big shout out to Lucia and @tranmartink on their amazing illustrations!.
The lives of cells, recorded #Perspective by @AskaryLab, Wei Chen, @_Choi_Junhong, Lucia Y. Du, @ElowitzLab, @james_gagnon, @schierlab, @sophieseid, @JShendure, @TanjaStadler_CH & @tranmartink.
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Bravo @adam_broerman! Really beautiful old-school design paper! this could open up new avenues for biosensor designs.
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits.
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amazing work! congrats Mo!.
Cute story alert!🧵@Caltech two clueless office mates (@piraner & I) created a tool to control cells with ultrasound. As postdocs (@UCSF & @UWproteindesign), we teamed up again (with @majo__duran & @AdamChazin) to build a tool for engineered cell signaling
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beautiful work! have been waiting for this for a while! congrats @JoshTycko.
Development of compact transcriptional effectors using high-throughput measurements in diverse contexts
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Beautiful paper and well summarized tweet! congrats @Yi__Fu.
Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells and our exploration of how cellular metabolism and transcription respond to deletion heteroplasmy. 1/19.
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Simply thrilled! Well-deserved recognition to David! Congrats! It's an exciting time to do protein design. Let's play more to modulate biology, or even create life.
BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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RT @IanRHum: Here’s our human protein-protein interactome. We mined the SRA, devised a new distillation dataset for protein complexes, trai….
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RT @Mohamad_Abedi: I'm sharing my story in a difficult time for Palestinians and Lebanon, where we found refuge after being exiled from Hai….
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Congrats @FloChardon @TroyMcDiarmid ! beautiful paper!.
Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to identify cell type specific regulatory elements is published!
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Thank you so much @ChenMaggieSY for writing up the report.
For @JShendure and @wchenomics at @uwgenome, it’s about appreciating a cell’s genetic journey over time, not just its final destination.
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Amazing work! Congrats @Nobu_Hamazaki and @VinetteY and all involved. I learned a lot from both Nobu and Wei on gastruloid!.
Excited to share our human RA-gastruloid model in @NatureCellBio! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in
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RT @ArvindSPillai1: Excited to announce our new paper on designing allosterically regulated protein assemblies from scratch, now published….
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