After six months, the ImmunoSketch project has officially reached its end. The goal? To take our intricate, jargon-heavy science and turn it into something your loved ones might finally understand—so they stop assuming you just “look at cells” all day. Immunology is hard to

Preprints start the conversation, and #PeerReview pushes research forward. That’s how every discovery we illustrate here takes shape. Our friends over at The Modern Peer are breaking it all down—check out their blog! #AcademicPublishing #OpenScience

This concludes our 10-day journey and the ImmunoSketch adventure. Thank you for joining in. May your new year be as resilient and adaptive as the cells we study. Happy new year! 🎄

And for the grand finale: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity. A perfect reminder of immunology’s complexity—how one decision can shape an entire fate.

Day -2 highlights an immune-sensory dialogue: A γδ T cell–IL-3 axis controls allergic responses through sensory neurons. Immunology doesn’t just fight disease—it listens, connects, and responds. A beautiful symphony of cells to close out the year.

On day -3, we spotlight adaptation: Immune system adaptation during gender-affirming testosterone treatment. A testament to the immune system’s flexibility and resilience—much like the spirit we carry into the new year.

Day -4 turns our focus to early development: Proteome asymmetry in mouse and human embryos before fate specification. A fascinating reminder that immune-related pathways often begin shaping outcomes before fate is even sealed.

On day -5, we celebrate immune cells in regeneration: Dynamic roles of ILC3 in endometrial repair and regeneration. Just like the new year brings fresh beginnings, ILC3s show us how the immune system fosters repair and renewal.

Day -6 dives into the mechanics of cell death: Septins promote macrophage pyroptosis. Who knew cell death pathways could bring such dramatic energy to the immunology stage?

Day -7 brings us a lesson in perfect timing: Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis. A reminder that, like the holiday season, the immune system knows when to act—and when to wait.

Day -8 shines a light on nature’s microscopic defense systems: Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. Like an immune system stocking stuffer, these mobile elements carry all the surprises—tools for attack and defense.

On day -9 of our year-end countdown, we celebrate immune engineering at its finest: A tetraspecific engager armed with a non-alpha IL-2 variant harnesses NK cells against B cell non-Hodgkin lymphoma. Natural killer cells armed and ready—it’s immunology’s version of Santa’s sleigh

Day -10: Today’s highlight takes us to the liver: Kupffer cell reverse migration into liver sinusoids mitigates neonatal sepsis and meningitis. Proof that even immune cells can come home for the holidays—and do remarkable things when they get there.

Some immune cells fuel the fire of disease, while others help put it out—finding the balance could change treatments. @Juliosds1 @BSheridanLab @jlb_journal @forum_gd https://t.co/8HpBNRQ9Wv

CAR-T cells aim to hit cancer targets, but when the target’s unclear, treatment struggles to succeed. @freemanlciaraMD @DrFredLocke @BloodJournal https://t.co/bPTq2SJzx8

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose. @mfgrp @DjenetBousbaine @kdbauman_ @plalgudi11 @BelkaidLab @Nature https://t.co/xXXCJx5VYm

Tracking bacterial ‘seeds’ in new soil reveals how they grow, adapt, and pave the way for next-gen microbiome therapies. @gangfang_1 @fanyu48696214 @MagdalenaKsi @jeremiahfaith1 @grinsa01 @NOKaakoush @IcahnMountSinai @biorxivpreprint https://t.co/QisGjqmInv

Unlocking how bacteria form tiny clusters like marbles could lead to better cystic fibrosis treatments. @DarchLab @AlexaGannon @jenetkay @USouthFlorida @USFHealth https://t.co/L3Af0Z7nQp

Think of a conductor guiding an orchestra—scientists discovered how T cells fine-tune their responses to keep the immune system in harmony. @MarsonLab @maya_arce_ @KroganLab @Satpathology @jkpritch @Nature @UCSF @GladstoneInst https://t.co/VeyYIs40LM

Neutrophils cast chromatin nets to trap tuberculosis, but these nets also feed the bacteria, fueling the disease. @StallingsLab @chanchal_sur @SthefanyCh @Mattila_TB_Lab @cellhostmicrobe https://t.co/RGDWLHnvJP