Journal of Experimental Medicine
@JExpMed
Followers
34K
Following
9K
Media
10K
Statuses
18K
The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress
New York, NY
Joined September 2009
New study from Kama, Tanaka, Hosokawa @Tokai_Univ_ et al. shows that #Notch-mediated reorganization of Runt-related transcription (RUNX) complexes and redeployment of RUNX-binding genomic regions are crucial for triggering the T-lineage program. https://t.co/bEW7nanqdx
0
0
5
Vini Tiwari & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders. https://t.co/rWzbs2QU7a 📘 In Neuroscience 2025: https://t.co/hdosfoXtBp
0
9
45
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. Stifter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. https://t.co/zaIRKxrVtT
1
3
15
Bronnec, Henry et al. @CIRI_Lyon developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. https://t.co/IKt5b5Js05
0
1
9
In this review, Lennol, Gratuze et al. assess all the available evidence regarding how two crucial elements are intertwined in #Alzheimers disease pathophysiology: tau and apoE. https://t.co/jnJqW4SuBC 📘 In Neuroscience 2025: https://t.co/tUVRAkGxj4
0
15
80
Papadopoulos, Kipnis et al. present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. 📘 In Neuroscience 2025: https://t.co/TQlJFUuuzh
0
16
74
The Gommerman lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission 📘 In Neuroscience 2025: https://t.co/a8B7pfNWwm
1
2
15
Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Leon Smyth, Rupal Mehta, Jonathan Kipnis @kipnislab @washu_pathology and colleagues: https://t.co/z22SNgDYXc
#Neuroinflammation #Alzheimers
0
6
34
Antunes, Zamponi et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. 📘 In Neuroscience 2025: https://t.co/6bRWjZJzz0
0
0
10
Frolov, Huang et al. show that #microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. 📘 In Neuroscience 2025: https://t.co/f0qEI42I54
0
5
32
Chatterjee, Zeiser et al. report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activation and T cell infiltration. https://t.co/B32U7UfZBT 📘 In Neuroscience 2025: https://t.co/q2jBcSTweP
0
1
17
Kun Yang, Nan Yan and colleagues show that the STING pathway drives non-inflammatory #neurodegeneration in NGLY1 deficiency. https://t.co/FaENBg65ZL 📘 Neuroscience 2025: https://t.co/ExMq3OTONl
0
0
10
🎥 New video summary from the study by Abdelaal, Gherardin, et al. of the @Jamie_Rossjohn and @WaelAwadMoh group "The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites" ( https://t.co/MWzTYvOCUF) 🔽 https://t.co/ybYRtyYLxi
0
0
5
See a short video summary of the study by Mohamed Abdelaal (Monash University) 🔽 https://t.co/hcJndcrHxn
0
0
0
Ping et al show that brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production. https://t.co/AkmgpFwWtu 📘 Neuroscience 2025: https://t.co/ikfdrtTkB3
0
0
14
JEM’s December Issue is here! https://t.co/oJDsYZ7uzU The cover image represents a #TB lesion in the lungs of C57BL/6 mice at day 21 after infection with M. tuberculosis HN878. See Branchett et al.: https://t.co/qi0ZRmTj2R
0
2
6
.@Jamie_Rossjohn and @WaelAwadMoh group show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation https://t.co/jPx2HwKZlU
1
4
20
Kurz et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche https://t.co/jlyV7BZx2E
0
5
21
Un equipo de investigación liderado por #LaComplutense, revela cómo el sistema inmunitario "llama a refuerzos" para prevenir las reinfecciones virales. El estudio dirigido por @salva_iborra, investigador en el departamento de Inmunología, Oftalmología y ORL de la @FMedicinaUniCM
.@ElenaHerndezGa1, @salva_iborra and colleagues @Unicomplutense show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. https://t.co/GPgXV2CZvb
#MucosalImmunology
0
8
21
Excited to share our new paper in @JExpMed ! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (Trm) amplify antiviral protection during reinfection. 🧵👇1/6
.@ElenaHerndezGa1, @salva_iborra and colleagues @Unicomplutense show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. https://t.co/GPgXV2CZvb
#MucosalImmunology
6
17
45