New preprint alert! We mapped a foundational protein-protein interaction (PPI) network involving 100 high-confidence (hc) autism spectrum disorder (ASD) risk genes, and leveraged AlphaFold2 to reveal a deeper mechanistic understanding of autism biology🧵👇 https://t.co/cdIC8cGmmF

QBI @UCSF launches the Paul Farmer African Initiative for Research (PFAIR) to strengthen research capacity across Africa by building a foundation for sustainable research through mentorship, funding, and international exchange for African scientists. https://t.co/z3K5BA5XWO

It was both inspiring and enriching to have this remarkable and synergistic group come together for the QBI Chromatin Symposium today!

Nevan Krogan @KroganLab @GladstoneInst @UCSF keynotes the first day of @SSP2024 with a manifesto on the universality of PPIs in human disease. “Every protein is important. And every protein is connected.” #TeamMassSpec #Proteomics

Excited to announce a Lunch & Learn with Dr. Nathanael Gray @Stanford on Oct 2, 12 PM at @UCSF's Bruker Center of Excellence in Proteomics! Learn about his cancer drug discovery work. Moderated by @rmkaake & Alicia Richards. Details: https://t.co/Qcy9IrGACd #CancerResearch

Exciting Opportunities in Cancer Systems Biology! Apply by Aug 9. 1- Training Program: Grad students, postdocs & senior scientists at @UCSF & @UCSD, join us! Up to 50% salary support for 1 year, with reapply option. More info: https://t.co/nZTwzcC90x

Hosted by @dlswaney & Chris Adams, QBI and @rezo_tx invite you to @UCSF Mission Bay on May 30 for a Mass Spec Symposium featuring a great line up of speakers and talks! If you haven't already, register to secure your spot: https://t.co/1IZauvk5mn #QBIRezoMassSpec #BayAreaScience

You're invited to the QBI – Berlin Integrative Mechanistic Biology Meeting! Join us at @UCSF Mission Bay from June 4-5 for a dynamic gathering hosted by Drs. Christian Freund @FU_Berlin, Natalia Jura @JuraLab_UCSF, and Nevan Krogan @KroganLab. Register! https://t.co/zple0v2yu8

Dive deep into the world of infectious diseases with us at the Systems Biology for Infectious Diseases training workshop, hosted by @rmkaake! Join us on April 12 @GladstoneInst for a day packed with insights from leading experts. Learn more: https://t.co/vx00TkHk49

The grand opening of the @Bruker Center of Excellence in Proteomics at the @UCSF Weill Neurosciences Building marks a significant milestone in research and innovation in neuroscience! Thank you to all who joined in celebrating this pivotal moment.

Join us for a presentation by Dr. Mohamed Samai from @COMAHS_USL on 04/10, as he shares the groundbreaking Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE), moderated by MS @IGHSatUCSF student Janesca Seif. Learn more & register: https://t.co/32UrYUkve6

The @UCSFSenate's 66th Annual Faculty Research Lecture in Basic Science is being awarded to Andrej Sali @salilab_ucsf for his work on computational biology and integrative structure modeling! Attend his lecture on 04/16 at Mission Bay Campus. Learn more: https://t.co/ZG0gDQYy1G

Join us on 03/27 @UCSF for a seminar by Lara Szewczak, Deputy Editor @CellCellPress, hosted by Nevan Krogan @KroganLab. Dr. Szewczak will share insights on publishing with Cell Press and provide a view on the career of a scientific editor. Don't miss it! https://t.co/trn77dUB1P

Don't miss our seminar with Zach Sweeney, head of therapeutic discovery at QBI, hosted by @KroganLab! With vast experience leading multifunctional drug discovery groups, Zach will discuss new drug candidates for neurodegenerative and inflammatory diseases. https://t.co/QOT2XEffQG

Rezo is excited to be included among @biospace's NextGen Class of 2024! 2023 was an important year for Rezo and we look forward to carrying that same momentum into the new year as we seek to unlock a new era of #drugdiscovery.

This project was a huge collaborative effort lead by scientists from @QBI_UCSF, @UCSFPsychiatry and @GladstoneInst, with important contributions from scientists at @rezo_tx, @IMSB_ETH, @emblebi, @institutpasteur and @UCSanDiego.

S/o to the 1st authors @belinda_p_wang, Rasika Vartak, @fimazaltsman & @SnowNaing1, from @WillseyLab & @KroganLab. Thanks also to @kelseyhennick, @bpolacco , @DoctorBou, Steven Finkbeiner, @TreyIdeker, @pedrobeltrao, Kirsten Obernier, @LabNowakowski, @rhuttenhain & Matthew State!

Overall, this work offers critical insights into molecular mechanisms underlying ASD, and describes a powerful platform that combines wt and mutant PPI data with AF2 to develop and test therapeutic strategies for a wide range of genetically-defined conditions.

We observed a patient-derived mutation in FOXP1 disrupting interaction with FOXP4, leading to a change in DNA binding sites and disruption of neurogenesis in human forebrain organoids. Consistent with previous work this has an impact on deep layer cortical and subplate neurons.

Using AF2, we provide molecular-level detail of the interaction interfaces of ADS-PPIs, enabling mechanistic hypotheses on mutational impact. We observed interface mutations more often result in loss rather than gain of interaction, even for low-scoring AF2 predictions.

We also generated a differential PPI map of 54 patient-derived missense mutations. This network suggests that damaging hcASD variants share changes in molecular function, with some interactors being commonly gained or lost across multiple mutant hcASD.