Journal of Leukocyte Biology
@jlb_journal
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Since 1964, JLB has published first-rate research on immunology-related topics, with emphasis on leukocyte physiology and behavior within the immune system.
United States
Joined January 2019
S100A9 is a novel regulator of SYK. Want to know more? Check out this #JLB research article by Wolf and others https://t.co/6Eq66ivjHp
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Predominant expression of the immunosenescent biomarker CD57 on CD4+ T cells and their subsets in the older people associating with the cardiovascular disease risk factors. Take a look at this #JLB article by Sornkayasit et al https://t.co/lbvym9kRwq
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Soucy and others show how platelet-derived microvesicles modulate the bioenergetic and inflammatory phenotype of human polymorphonuclear leukocytes. Learn about this and more in this issue of #JLB
https://t.co/WdbUxYWGPt
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Take a look at this #JLB article by Helder et al. Trained macrophages show increased cytokine production and antigen presentation while driving contact-dependent Th17 polarization of T cells in an antigen nonspecific manner. https://t.co/NlVeCnskxU
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Early changes in the eosinophil-to-lymphocyte ratio at 24 h may serve as a biomarker for severity stratification in SARS-CoV-2 patients admitted to the ED but are insufficient alone to predict mortality. Find out more in this #JLB article by Godfrin et al https://t.co/jCXtJLkzHc
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The F4/80 antigen is a plasma membrane pan-marker for resident and recruited mouse tissue macrophages. Want to know more? Check out this #JLB article by Gordon and others https://t.co/9Gnbf887Q8
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Matrix metalloproteinases are key regulators of intestinal homeostasis and disease, influencing progression of IBD and colorectal cancer, and offering both therapeutic and biomarkers potential. Read more in this #JLB article by Manzanares https://t.co/xLxLDfnMa4
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Check out this #JLB article by Liu and others to learn how senescent cancer cells exhibit complex interactions with the immune system, featuring both immune stimulatory and immune evasive properties that shape cancer progression and therapy. https://t.co/YCp0ZuISzs
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Learn how infection of the liver by HIV, hepatitis B virus, and/or hepatitis C virus impact the bidirectional molecular mechanisms that mediate the effects of macrophage and liver dysfunction in disease in this #JLB article by Brantly and others https://t.co/YGcM1Nqspb
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Zhao's team explains how neutralizing antibodies effectively block both IGF-I and IGF-II from activating IGF-1R and its hybrid receptors, thereby disrupting crucial growth and survival signaling pathways in #JLB. https://t.co/X6qusS7ZHm
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Take a look at this article by Ringer and others in the latest issue of #JLB to learn how the absence of myeloperoxidase results in aggravated skin and joint inflammation in murine mannan-induced psoriatic arthritis by altering neutrophil function. https://t.co/p37ATYDAqa
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Neutrophil antimicrobial functions decline in older people, this is exacerbated in older people with frailty; chemotaxis & phagocytosis are enhanced in centenarians to levels comp to healthy younger adults. Learn more in this #JLB article by Abdullah et al https://t.co/FokUu7jHB1
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Low peripheral blood HLA-DR+CD3+ T cell counts 3 mo post allogeneic stem cell transplantation are associated with an increased transplant-related mortality & higher rate of cGvHD grade 2 to 3. Check out this article by Koeck et al and more in #JLB
https://t.co/lBGb6D2Dm1
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Cao's team shows how treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization in the latest issue of #JLB
https://t.co/cIHI64Lrjg
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The bactericidal and thrombotic potentials of extracellular TRAP-enclosed neutrophil vesicles released in response to Staphylococcus aureus at high glucose concentration. Want to learn more? Check out this #JLB article by Mohan and others https://t.co/Ik9gyLhYO3
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Take a look at this #JLB research article by Kalinina and others. Secreted cyclophilin A regulated the functional activity of T and B cells, influencing the development of the adaptive immune response. https://t.co/MVOkO1kT1J
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Neutrophil proteins & RNA are present in megakaryocytes & platelets of patients with myeloproliferative neoplasm, suggesting the transfer of biological constituents occurred during megakaryocyte emperipolesis. Learn more in #JLB Collinson et al https://t.co/VzyxakOFcc
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SLB 2024 legacy award presentation: Mechanisms of immune suppression in sepsis/shock: one investigator's/lab group's experience. Take a look at this review Alfred Ayala in the latest issue of #JLB
https://t.co/8HZPO6M7OK
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Take a look at this research article in #JLB by Liu et al to learn how tumor-infiltrating CD103+CD8+hnRNPA2B1+ tissue-resident T cells can serve as an unfavorable prognostic factor for ccRCC patients. https://t.co/DyZl10WskA
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An IL-15-modified NKp30×HER2 trispecific NK cell engager enhances NK cell activation and tumor cell killing. Learn more in this #JLB research article by Cheng and others. https://t.co/W4lzxyezRs
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