Journal of Leukocyte Biology
@jlb_journal
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Since 1964, JLB has published first-rate research on immunology-related topics, with emphasis on leukocyte physiology and behavior within the immune system.
United States
Joined January 2019
An IL-15-modified NKp30×HER2 trispecific NK cell engager enhances NK cell activation and tumor cell killing. Learn more in this #JLB research article by Cheng and others.
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Take a look at this #JLB review by Nussbaumer and others as it highlights the critical role of posttranslational sialylation in regulating neutrophil biology and examines its potential as a therapeutic target in inflammation, infection, and cancer.
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Check out this article Roy's team Ribosomal protein L13a regulates macrophage polarity in the latest issue of #JLB.
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Learn how downregulation of MicroRNA-93 inhibits proliferation and promotes apoptosis and hematopoiesis in myelodysplastic syndrome cells through PAG1-mediated epidermal growth factor receptor signaling pathway in this #JLB article by Liu and others
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Berbamine promotes autophagy and GPX4 expression through inducing abundant ROS to restrict HIV-1 and Mtb coinfection in macrophages. Learn more in this #JLB research article by Zhou and others.
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Check out this #JLB article by Zúquete et al showing how aged DCs stimulated via TLR2/TLR4 produce less TNFα and more IL-10, and prime CD4+ T cells to a less pronounced type-1 cytokine expression profile with reduced levels of the gut homing receptor CCR9.
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This study by Sun's team found that histone-lysine N-methyltransferase 2D can antagonize the AKT-mTOR pathway by upregulating SMG1 expression through histone methylation, thereby promoting ferroptosis in diffuse large B-cell lymphoma cell. #JLB
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Apolipoprotein A-I is preferentially expressed by a subset of human neutrophils with high side-scatter as a potential counter-regulatory, feedback mechanism to attenuate excessive inflammation. Find out more in this #JLB article by Yao and others
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Check out the #JLB article by Phillips et al to learn how microscale arrays enabled the characterization of the neutrophil swarming response to the hyphae of Candida albicans & provided insights into molecular mechanisms that drive & regulate the process.
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Tumor-associated neutrophils play a crucial role in fostering an immunosuppressive microenvironment that enables tumor immune evasion. Dive into this #JLB article by Xiao to learn more!
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In a peanut allergen model, we observed significant sex-based differences in immune response and circadian clock gene expression. To find out what we learned, take a look at this #JLB brief report by Santhosh Kumar Duraisamy and Isaac Kirubakaran Sundar .
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Take a look at this #JLB research article by Teghanemt and others! Mutation of mazF in Staphylococcus aureus decreases susceptibility to killing by hypochlorous acid and by human neutrophils.
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Arginine metabolism supports metabolic reprograming in β-glucan trained human primary monocytes, allowing for more effective functional responses. To learn more, check out this #JLB research article by the Laura M Merlo Pich team.
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Check out this #JLB article by Channer et al to learn how serum availability alters human macrophage nuclear factor κB dynamics and inflammatory functions including cytokine secretion and phagocytic capacity in response to macrophage activation in vitro.
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Learn more about how metainflammation alters neutrophil function and migration in vivo in response to tissue injury in this #JLB research article by Michael and others .
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Transcriptional programs underlying human monocyte differentiation and diversity. Check out this #JLB article by Komaravolu and others to learn more!.
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Learn more about the potential functions of TRPM2 and TRPM7 channels in the tumor microenvironment in this #JLB article by Izaguirre-Hernández and Sumoza-Toledo .
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Could Neutrophil CD300ld be a savior of organ failure? Read this discussion on the role of CD300ld-mediated phagocytosis by neutrophils in the context of organ damage in sepsis using a murine model in this #JLB article by Jeansonne and Jeyaseelan .
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Fibroblast activation protein on human natural killer cells: insights from natural killer cell activation and crosstalk with cancer-associated fibroblasts. Take a look at this #JLB article by Yentl Van Rymenant et al to learn more!.
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