GoT-ChA! I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in @Nature !! 👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples: https://t.co/M9Y3wEvpuW 👇🧵

Nature research paper: Functional synapses between neurons and small cell lung cancer https://t.co/8OCZyKfqQD

Our team is excited and honored to see our new method, HT SpaceM, for high-throughput single-cell metabolomics published in Cell! https://t.co/OEgNiEHgib 👇

DNA methylation in mammalian development and disease https://t.co/XShWAoBisC #Review by Zachary D. Smith @YaleMed, Sara Hetzel (@hetzel_s) & Alexander Meissner @MPI_MolGen Free to read here: https://t.co/MJWXDPXcyQ @maxplanckpress

Amazing new paper from ⁦@nicholas_navin⁩’s lab! Coalescing single-cell genomes and transcriptomes to decode breast cancer progression: Cell

Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18

Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team!

Nature methods: Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues https://t.co/P6GFcDcCfP

Excited to share our latest work @Nature! We show that the total number of hematopoietic stem cells (HSCs) in the body is restricted, challenging the classical model that HSC numbers are determined locally by the niche and introducing a new paradigm. (1/9) https://t.co/kvFqNQ8Nxb

A new bioRxiv preprint from the @landau_lab at New York Genome Center showcases the unmatched combination of sensitivity, efficiency, and cost-effectiveness made possible by #ppmSeq. Link to preprint: https://t.co/Ktk14kMfIm Link to PR: https://t.co/WBBdgweOwx

🧨Exciting new pre-print! Introducing ppmSeq - cost effective, scalable dual-strand 🧬 sequencing. Scalability & ultra-low error in one! A game changer for somatic genome discovery science and cfDNA clinical apps. Check out thread for deets! @AlexandrePCheng @UltimaGenomics

Highly accurate sequencing OR high throughput? We refuse to choose. Introducing paired plus-minus sequencing (ppmSeq), a method built to deliver both. Our latest paper with @UltimaGenomics 👀👀👀 See ⬇️ for a primer on the next frontier of genomics https://t.co/kl2KOaKziW

Researchers have developed a #DeepLearning system called BioEmu that rapidly generates diverse protein conformations, enabling fast, accurate insights into protein flexibility and function. Learn more this week in Science: https://t.co/Pe15hm9F52

Science doesn’t need to go according to plan; it just needs to lead to a discovery. If doesn’t have to be done alone or together with a buddy; there just needs to be a discovery. It doesn’t need to happen fast or slow; just as long as there’s a discovery, then everybody is happy.

Recently published: Multimodal and Data-Driven Assessment of Myeloid Neoplasms Refines Classification across Disease States https://t.co/zhHhCQrS7I

Single-cell multitargets and mRNA sequencing enable the simultaneous profiling of transcriptome and up to six histone modifications in individual cells @RuggGunnLab @ScienceAdvances https://t.co/wpoUXLClye https://t.co/xkOa8IQHzJ preview by @haiqi_chen

In GWAS studies, moving from a significant genomic locus to the driving genetic variants is challenging due to linkage disequilibrium. This review summarizes statistical fine-mapping methods that aim to detect potentially causal variants among sets of candidate variants.

Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity https://t.co/Twl44S84Ps #stemcells

Enriching polygenic risk scores with single-cell ATAC-seq about chromatin accessibility in disease-relevant cell types shows potential to 👉improve predictive performance 👉better understand cells driving genetic predisposition to disease 👉uncover specific molecular drivers

For innate immune cells, the lack of diverse receptor rearrangements has prevented the study of clonal evolution of the innate immune system in human tissues and tumors. With @satpathology and @caleblareau, I’m delighted to share my PhD work that tackles this challenge:

Time to mark our calendars moving for our 3rd "Probing Human Disease using Single-Cell Technologies" @Fusion_Conf taking place March 1-4, 2026 in beautiful Playa Mujeres, Mexico!! Our first 15 speakers are already on board and Early Bird and Talk submissions on Sept 3rd! Dont