Ansu Satpathy
@Satpathology
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Cancer immunology and genomics @Stanford @Wing_VC @GladstoneInst @CartographyBio @Immunaitech @parkerici
Joined July 2015
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20 years ago, I sent ~100 cold emails to PIs asking to work in their labs with no immunology experience. Diane was the only one who said yes. I drove across the country and stayed in youth hostels so I could work in her lab, and it started my career. Congratulations, Diane.
Celebrating the inaugural awardee of the Menarini Prize for outstanding woman Immunologist : Pr. Diane Mathis
@harvardmed
- congratulation Diane
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To me, a major problem is the viewpoint that there is/should be a one-way flow from academia -> industry. Academia should recruit industry scientists at all levels and vice versa. Half of our lab has sig industry experience and it has transformed the way we approach questions.
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Happy to share our study on CRISPR screens of T cell exhaustion! We find that targeting chromatin remodeling factors can improve T cell persistence and anti-tumor immunity. Awesome genomics + cancer IO work led by Julia Belk, Winnie Yao, Nghi Ly, and many terrific collaborators!
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
#bioRxiv
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Delighted to share our story out in
@Cancer_Cell
! Incredible amount of work led by Julia Belk and Winnie Yao, and wonderful collaborations with many close colleagues
@SantoshVardhana
@jccarnevale
@MarsonLab
@MackallLab
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Excited to announce that our lab is joining the Gladstone Institute of Genomic Immunology! Looking forward to teaming up with
@Marsonlab
to pursue the next generation of genomics-inspired immunotherapies and bridging
@StanfordMed
@parkerici
and
@Gladstone
communities.
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Our lab thinks a lot about the epigenetic regulation of T cell exhaustion. Happy to have a chance to discuss important prior work that has influenced our thinking as well as our own speculations in
@NatImmunol
. Led by Julia Belk and
@BenceDaniel2
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Excited to announce that I will be starting my lab in the Department of Pathology at Stanford! Now recruiting students and postdocs interested in studying cancer immunology with epigenomic and single-cell technologies!
@StanfordPath
@parkerici
@CancerResearch
#immunotherapy
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Just got back from reviewing K08 applications
@theNCI
and thought I'd share some of my observations 1/
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Immunotherapies are only as effective as their targets. Excited to share the launch of Cartography Bio, focused on finding safe and effective antigens for every cancer patient. Wonderful to work with founders
@krparker
@HowardYChang
@MaxMumbach
@CalebLareau
@JeffreyVerboon
We’re excited to officially launch Cartography Biosciences today with $57M in initial financing. With this support, we will create a smarter roadmap for
#cancer
immunotherapies with our precision antigen expression atlas. 🧵
#Oncology
#MedTwitter
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Very happy to share our paper on CD19 expression in human brain mural cells! A wonderful collaboration with many people across institutions
@krparker
@HowardYChang
@IAmDrDex
@carlhjune
@MiglioriniDenis
and many others.
@parkerici
@CancerResearch
@StanfordPath
@PennMedicine
New Article online now at Cell: Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
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I’m excited and grateful to expand my partnership with the Wing VC team! It’s an incredible moment in time to build impactful therapeutics driven by new approaches in data and computation. I’m excited to spend more of my own time partnering with founders to bring that vision
We're beyond thrilled to welcome Ansu Satpathy
@satpathology
as a partner on the Wing team, joining
@SaraChoi_
leading our cutting-edge bio x data investments. Welcome Ansu!
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Our paper on simultaneous single-cell T cell receptor and epigenome sequencing is out! Awesome collaboration with
@NareshaSaligra1
@JD_Buenrostro
@HowardYChang
Mark Davis
@WJGreenleaf
and others
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Our paper mapping 3D enhancer-promoter connections in primary human T cells is out!
@NatureGenet
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congratulations to
@HowardYChang
- well deserved, for genome science, and for steadfast and thoughtful mentorship!
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Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion | Another great team effort with
@JeffreyGranja
@10xGenomics
@gracexyzheng
@WJGreenleaf
@HowardYChang
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
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Excited to share our preprint tracking the T cell response to PD-1 blockade in patients using single-cell RNA/TCR-seq!
Truly an awesome collaboration with
@KatieEYost
, Anne Chang,
@parkerici
(Danny Wells, Samantha Bucktrout), Mark Davis, and of course
@HowardYChang
!
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Clonal replacement of tumor-specific T cells following PD-1 blockade | Great collaboration with
@KatieEYost
@parkerici
Anne Chang
@HowardYChang
After anti-PD-1 therapy in basal or squamous cell carcinoma patients, the CD8+ T cell response largely consists of an expanded and exhausted repertoire of new
#Tcell
clones |
#ImmunoTherapy
@HowardYChang
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This paper really reinforces my belief in engineering the immune system via first principles and basic research, where detailed conceptual understanding can lead to 'simple' modifications that dramatically alter the system. A must read
I’m very excited to share our paper published in
@NatImmunol
describing how T cell lineage fate is determined!
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New year, new people, new website! A belated welcome to many wonderful and brilliant new members of the lab!
@StanfordPath
@parkerici
@CancerResearch
@HumanVacProject
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Happy to share the beautiful work of
@joyp_ai
@AndrewChowMDPhD
Matt Hellmann and many wonderful collaborators
@MSKCancerCenter
!
@parkerici
@CancerResearch
@pewtrusts
Excited to share that our work on regional T cell clonal responses to immune checkpoint blockade is out now! Very grateful to
@AndrewChowMDPhD
, Matthew Hellmann,
@Satpathology
, and all other co-authors for this wonderful collaboration.
Check it out here!
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@theNCI
@biorxivpreprint
papers were viewed very favorable. Often heard ‘if only we could see a pre-print of the paper’
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Happy to share our study profiling SARS-CoV-2 RNA- host protein interactions! Terrific teamwork with
@raflynn5
@juliabelk
@WilenLab
and many
@StanfordMed
@Yale_LabMed
@Stanford_ChEMH
collaborators!
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Wonderful collaboration with
@JeffreyGranja
@10xGenomics
@gracexyzheng
@HowardYChang
@WJGreenleaf
! We develop single-cell ATAC-seq in droplets and study human hematopoiesis and intratumoral T cell exhaustion after PD-1 blockade
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
#bioRxiv
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We are incredibly grateful to
@CancerResearch
! Talk about an institute that has a mission and conviction to provide flexible long-term funding for high-risk ideas. It's no wonder that CRI has been at the center of the immunotherapy revolution.
Congratulations to 3 (!!)
@GladstoneInst
@UCSF
Genomic Immunology faculty on their
@CancerResearch
Lloyd J. Old STAR awards!
@SpitzerLab
@Satpathology
@KoleRoybal
@roybal_lab
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Excited to see the launch of Immunai! Terrific team of immunologists, data scientists, and ML engineers. The future is bright for cancer immunology and AI!
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Thanks
@NatureBiotech
for highlighting our work at
@CartographyBio
. The future of targeted immunotherapies will not be limited to CD19 and BCMA!
Next on our list of the best
#NBTAcademicStartups
spun out from academic institutions in 2022 are Cartography Biosciences and Nested Therapeutics, two startups taking a deep dive into cancer genomes to unearth new therapeutic targets
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Happy to share our study mapping the SARS-CoV-2 viral RNA-host protein interactome! So fun to work with RNA wizard
@raflynn5
@juliabelk
@WilenLab
and many terrific collaborators
@Stanford_ChEMH
@Yale_LabMed
We can finally hear the ChIRPing of the SARS-RNA-interactome! Very collaborative work w/
@juliabelk
@Satpathology
@CarolynBertozzi
@WilenLab
JanCarette
@HowardYChang
others! |
@yaleibio
@Stanford_ChEMH
@StanfordMed
@BWFUND
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What’s in your product?
Out today in
@Nature
, we describe HHV-6 reactivation in T cells, including therapeutic CAR T cells. I’m so grateful to have worked with an all-star team during my time in the
@Satpathology
lab that led to these findings. 1/n
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Excited that our team will be part of the IGVF consortium
@genome_gov
together with wonderful colleagues
@CalebLareau
@yimmieg
@doctorcorces
@MayaKasowski
@LeifLudwig
James Gardner
WANTED: Information on genomic variants. Are they friend or foe? We need our best people on the case! We are providing funding to investigators who can help determine how genomic variation alters genome function and how variation affects human health.
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Delighted to share our work defining the epigenetic state and new regulators of tissue-resident memory T cells! Wonderful collaborative effort led by
@buquicchioli
and
@raissaf
in what I hope is the first of many joint efforts with
@LMackayLab
!
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Reactivation of latent HHV-6 in CAR-T cells. Terrific work by
@CalebLareau
in a close collaboration with many academic and industry colleagues. We hope this finding will help support the continued development of safe and effective cell therapies.
Encephalitis caused by human herpesvirus 6 has been repeatedly observed in CAR-T cell case studies and clinical trials. In a new work with
@satpathology
, we make the surprising observation that the cell therapy itself may be the source of lytic virus. 1/n
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What's our lab reading these days? A couple of recent journal club papers that got us excited:
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Happy to share an awesome story from the incredible
@KatieAnnFreitas
Julia Belk and many colleagues in another terrific collaboration with
@MackallLab
@parkerici
@CancerResearch
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The future of immuno-oncology will be driven by developing broad clinical pipelines targeting novel cancer antigens - and the synergy of cancer-directed therapies (ADCs, BITEs, CARs) with immune-directed therapies (PD-1, etc). we have plenty of hammers, time to find the nails
Bright Minds: Searching for novel targets in IO with the co-founder and CEO of
@CartographyBio
.
Full video:
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Even though I think about T cells every day, seeing 10 year (!) persistence of functional CAR-T cells in humans is absolutely incredible.
Penn Patients with Decade-Long Leukemia Remissions after CAR T Cell Therapy Reveals New Details About Persistence of Personalized “Living Drug” Cells. Delighted to announce our study in Nature today
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Happy to share terrific work from terrific scientists
@BenceDaniel2
@KatieEYost
Sunnie Hsiung with generous and fun collaboration from
@FW14B_Red5
@HowardYChang
@facts___matter
@EJohnWherry
and many others
Exciting to see our work out
@NatImmunol
. A real team effort with
@KatieEYost
Sunnie Hsiung
@HowardYChang
@FW14B_Red5
@Satpathology
& many others.
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Look what
@CalebLareau
found in my blood! 🧐
Out on
@biorxivpreprint
, I'm excited to share our latest deep dive into the world of mitochondrial genetics using single-cell genomics. Grateful to have worked with
@LeifLudwig
,
@Satpathology
, and many others. Thread here: 1/n
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IMHO this is the best of what academia has to offer: innovative, collaborative, pushing the boundaries of translational medicine and basic biology. Well done!
T cell lymphoma mutations power adoptive T cell therapies! Excited to see this published! A true collaboration with friend and colleague
@koleroybal
and our students
@jay__daniels
and
#julie_garcia
.
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Thanks to
@HaydnKissick
and Rafi Ahmed for their wonderful perspective on our recent story - one of the best parts of academia is when scientists that you greatly admire give feedback and review your work!
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Happy to share our perspective on checkpoint blockade. With long time partners in crime
@KatieEYost
@HowardYChang
So much incredible work recently on tumor-extrinsic responses to checkpoint blockade - thrilled to our perspective with
@HowardYChang
@Satpathology
out now in
@ScienceMagazine
!
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Pam supported and mentored me early in my career - just because. We didn't collaborate, I didn't train with her, and we were miles apart. It meant a lot. Thanks
@PamSharmaMDPhD
Celebrating our amazing mentor, colleague & friend
@PamSharmaMDPhD
❤️. Thank you for everything you do for all of us!!
@BettyKimLab
@DrAriaV
@aaparicioMD
@MarlaPolk8
@LyndaChin
&Sumit Subudhi.
@MDAndersonNews
.
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our recent commentary on utilizing single cell genomics to design targeted cancer therapies in
@CancerCell
Thrilled to have worked with Kevin Parker and
@Satpathology
on our new commentary out in
@Cancer_Cell
where we discuss the state and the future of targeted therapies in fighting cancer-- A short thread on our ideas:
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congratulations to new NAS members
@HowardYChang
and
@carlhjune
! Well deserved for such generous mentors of young scientists.
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Excited to announce a new joint postdoc fellowship program in data science with the Parker Institute for Cancer Immunotherapy! Please share and apply!
@parkerici
@StanfordMed
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another banger from
@BenceDaniel2
@andy_yhchen
@SandorDanielne
evidence that innate immune memory is programmed by 3D chromatin architecture
@4DNucleome
Excited to share our work with
@andy_yhchen
,
@SandorDanielne
,
@Satpathology
, and others on how inflammation-induced 3D genome conformation can integrate distinct inflammatory signals, and provide transcriptional memory in macrophages.
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is there anyone who knows more about TCR Tx than
@KlebanoffLab
? probably not
🚨🧬💉Everything you wanted to know about TCR therapies* (*but were afraid to ask). Check out our new review in
@NatRevDrugDisc
👇. A wonderful collaboration between
@KlebanoffLab
,
@ND_BakerLab
,
@QuezadaLab
, and
@ToniRibas12
.
@MSKCancerCenter
@parkerici
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Thrilled for
@CalebLareau
who is an exceptional scientist and mentor and will continue to make important discoveries across many fields!
Some big news: I’m absolutely delighted to announce that I will be starting my group this fall in the Computational and Systems Biology Program at
@MSKCancerCenter
in New York City! 1/
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awesome collaborative work led by
@BenceDaniel2
@KatieEYost
identifying new Tex cell types and clonal trajectories of T cell exhaustion
Excited to share our preprint on clonal T cell differentiation trajectories of T cell exhaustion. Great collaboration with
@KatieEYost
@HowardYChang
@FW14B_Red5
@Satpathology
and others
@StanfordMed
.
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ENTER-seq for high-throughput mapping of receptor-ligand interactions! awesome work by
@BingfeiY
Quanming Shi
Excited to share our 3-in-1 viral platform to capture receptor-ligand interaction and connect such communication with molecular phenotype at the single-cell level🥳
It's fulfilling to see "crazy" ideas end up to be a great platform as they often fail🤣
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We
#WearWhite
to support the many dedicated scientists, medical professionals, and organizations that are working to improve the lives of cancer patients through immunotherapy.
@CancerResearch
@parkerici
#hackcancer
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Fun collaboration with creative colleagues
@adamjrubin
@krparker
! We developed a single-cell platform to screen epigenomic phenotypes with CRISPR.
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4 years ago I read a brilliant paper from
@samuels_yardena
@NCIEytanRuppin
on tumor heterogeneity and its impact on immune rejection and knew
@joyp_ai
and I had to work with them. some cold emails and lots of fun later…
Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion
#biorxiv_cancer
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I would have never studied immunology without my undergrad mentor Diane Mathis. This article is data nonsense
@NatureComms
Yeah my three female mentors
@BelkaidLab
@JulieSegre
and Elaine Fuchs really held me back professionally 🙄....What the actual F$&!
@NatureComms
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a true pleasure to partner with
@JorgeCondeBio
@beckypferdehirt
and the entire
@a16z
bio team
@vijaypande
@vintweeta
@julesyoo
@JayRughani
Cancer immunotherapies are only as good as their targets — they must kill cancer cells while sparing healthy ones. 🎯
By bridging the worlds of biology + computation,
@CartographyBio
is building a comprehensive atlas to navigate this tricky terrain. 🗺
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Perturb-ATAC! A method to perform CRISPR screens for epigenomic phenotypes in single cells.
Excited to share this work, a great collaboration with
@krparker
,
@Satpathology
and many others
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Patient Treg mutation -> mouse model -> chromosome conformation. Nice work by Fred Van Gool
@kickassscience1
and many collaborators.
@Immunity
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Look out immunology world for this outstanding young scientist!
Incredibly honored to present some of my postbac research next to other amazing scientists
@sacnas
in San Juan! have enjoyed listening to trailblazing scientists, talking to different graduate schools, and eating mofongo and tostones ¡Wepa!🇵🇷
#NDiSTEM2022
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terrific paper from
@MangusoLab
Dubrot et al use genome-scale in vivo CRISPR screens to look at
#immune_evasion
mechanisms across
#cancer
models, showing that IFN-mediated upregulation of classical and non-classical MHC class I inhibitory checkpoints facilitate immune escape.
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For anyone looking to do scATAC-seq analysis, here is your solution!
Excited to announce ArchR () an R package for scATAC! Great collaboration with
@doctorcorces
,
@Sarah_E_Pierce
,
@HowardYChang
, and
@WJGreenleaf
! ArchR has a diverse toolset and can analyze upwards of a million cells on a Macbook Pro!
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it's always such a thrill to collaborate with
@EvanWeberPhD
- congratulations to
@andy_yhchen
@alexdoan96
@kpmueller1
and the team!
Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?
We answer this in our lab’s first paper in
@Nature
led by
@alexdoan96
@kpmueller1
@andy_yhchen
. 1/
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@theNCI
Proposing specific aims that were recently published (or significantly resembled published work) was a major no no for most reviewers
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@theNCI
Sticking with the same postdoctoral mentor for the training period of the K08 was sometimes viewed as a negative, if the committee felt that there was nothing more for the candidate to learn. Switching to a new mentor with justification was usually viewed as a big plus.
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Congratulations to
@CalebLareau
!
They are rising star researchers with ideas that can change cancer care as we know it. Congratulations to PICI’s 2021 class of early career research awardees!
#CancerFearsPICI
@BeltraJC
@Themis_Brown
@EvanWeberPhD
@CalebLareau
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very interesting work by Sangya and Carl - and also supports the view that PD-1 KO will not meaningfully improve CAR-T function.
Excited to share my Ph.D. work in
@carlhjune
lab showing uninhibited CD28 co-stimulation via CTLA4 disruption invigorates dysfunctional CART cells
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Wonderful collaboration on the CD4 T cell response to chronic antigen with
@FW14B_Red5
lab - led by Yu Xia,
@SandorDanielne
, and
@joyp_ai
!
Now our new paper is online.
Great collaborative work
#2
(many more to follow) with Ansu Satpathy
@Satpathology
.
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Wonderful teamwork with
@warshpower
@juliabelk
and the Anderson lab understanding the function of a human mutation that causes Type 1 diabetes.
@JDRF
.
@warshpower
, Belk, Anderson et al
@UCSF
establish a STAT3 gain-of-function mouse model that recapitulates the human type I
#diabetes
phenotype by driving cytotoxic CD8+ T cells that are epigenetically distinct & resistant to terminal exhaustion
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Terrific review by
@joyp_ai
on single cell TCR- and multi-omic-seq!
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Thanks to
@patrickc
@tylercowen
and the rest of the Fast Grants team. We will move fast too.
• Day 11.
• 67 awards made.
• $12M distributed.
• Starting to list the scientists and their projects here: .
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Beautiful discovery from one of the most thoughtful scientists I know!
Tumors spread to lymph nodes before they metastasize to distant tissues, but for over a century scientists have debated whether this matters. It does. Check out our paper online now
@CellCellPress
@CellPressNews
1/15
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PERFFect method from PERFFect trainees. congratulations to
@tsion_abay
@CalebLareau
#BobStickels
and team!
What a PERFFect day to share our new preprint!
With
@tsion_abay
#BobStickels
@MerilTakizawa
@ChaligneRonan
and
@Satpathology
, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. 1/n
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beautiful work from
@joyp_ai
and
@AndrewChowMDPhD
describing T cell dynamics in lung cancer! Among other things, we find clonal evidence for TEx precursor cells in tumor-draining human LNs
Very excited to share our work on regional T cell clonal dynamics in lung cancer! Honored to be able to work with and learn from
@AndrewChowMDPhD
, Matthew Hellmann,
@Satpathology
,
@charlesrudin
,
@merghout
,
@wolchokj
, and many more.
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Thanks
@AnaAndersonlab
!
.
@AnaAndersonlab
& Acharya preview the
@NatureMedicine
paper from
@HowardYChang
, Chang, Satpathy &co showing that T cell clones that dominate the intra-tumoral T cell landscape after immune checkpoint blockade are distinct from those prior to treatment
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@theNCI
Several people had previously told me that specifics of the proposed research were not as important for transition awards. Not true, a LOT of time was spent digging into the research plan.
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Much appreciation for the lab's first postdoc
@BenceDaniel2
for helping to kick-start the lab!
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Such an awesome discussion from the beautiful mind of
@mfgrp
. every student should read this
'It is better to treat ideas like leeches that are trying to make a meal of your time.'
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Awesome paper from
@MarsonLab
- synthetic alleles + HT screening + immunology is the future
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Thanks!
@10xGenomics
has been a terrific parter for tech innovation in our lab. The Flex assay was essential for developing this advance
We’d like to celebrate the innovation of PERFF-seq by
@tsion_abay
@ChaligneRonan
@Satpathology
&
@caleblareau
! Their work, which leverages the Chromium Flex assay, will pave the way for new studies of rare cells. 👏
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Congratulations to the
@Immunaitech
team! Thrilled to be part of the fun ride
@Immunaitech
is now a UNICORN 🦄and on the right path to redefining drug development. Congrats
@NoamSolomon1
and Luis Voloch
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Thanks to
@CancerResearch
for their continued and critical support of our work!
Dr. Ansu Satpathy (
@Satpathology
), a
@CancerResearch
Tech Impact Award recipient at
@StanfordMed
, is building a single-cell atlas to help us better understand why some people respond to cancer
#immunotherapy
but not others.
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Excited to welcome Dan to the
@CartographyBio
team!
We’re pleased to announce the appointment of Dan Rock, Ph.D., as CSO.
As a proven
#drugdiscovery
leader, Dr. Rock will drive Cartography’s novel
#oncology
programs into the clinic, with an initial focus on our lead CB21 program for colorectal
#cancer
.
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Fun working with the Egawa lab
@FW14B_Red5
@sraju89
and
@BenceDaniel2
@KatieEYost
to understand the source of memory T cells in chronic infection! Multiple cell subsets and trajectories in T cell exhaustion
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another awesome team effort led by the incredible
@BenceDaniel2
!
Happy to share that our work is online
@MolecularCell
. Our single-cell chromatin atlas of macrophage polarization reveals cyclical macrophage plasticity states in cell cycle. Great collaboration with Julia Belk,
@HowardYChang
&
@Satpathology
.
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really cool paper from
@IdoAmitLab
and colleagues!
We are excited to share our
@NatureCancer
paper showing how interactions between subtypes of T and dendritic cells shape the tumor microenvironment in patients with different types of cancers and can enhance the response to checkpoint blockade therapy
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Awesome work identifying a new Aire-expressing cell population by
@CalebLareau
in collaboration with
@gardnerlabUCSF
!
Thrilled to see this collaborative work out in
@SciImmunology
led by
@JessicaWang927
and
@gardnerlabUCSF
at
@UCSFDC
and Stanford in the
@Satpathology
lab
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beautiful method and study, looking forward to trying this out!
Presenting Slide-TCR-seq: our method for measuring the transcriptomes of cells & T cell receptor (TCR) sequences in situ!
This collaboration w/ Bryan Iorgulescu, Shuqiang Li, Catherine Wu, and
@insitubiology
led to some cool findings...
1/8
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Terrific new work by
@cmcginnis92
on immune remodeling during tumor metastasis!
@parkerici
@CancerResearch
@pewtrusts
(1/22)🚨NEW
@biorxivpreprint
PRE-PRINT🚨Longitudinal scRNAseq analysis of immune cells in the metastatic niche. From primary tumor formation thru pre-met niche to end-stage disease. 1st paper of my postdoc with
@Satpathology
@JulianeScience
@RetickerFlynn
🧵
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Happy to highlight work from
@YuriPritykin
and the Leslie lab on genomic pathways to T cell dysfunction with
@SandorDanielne
@BenceDaniel2
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thank you
@vcluca1
@JenBinning
@PatrickHwuMD
and many colleagues for a wonderful visit and exciting science
@MoffittResearch
!
Had a great time hosting
@Satpathology
for his Grand Rounds seminar at
@MoffittResearch
today. Many interesting perspectives on how single-cell genomics can guide us towards better immunotherapies.
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@theNCI
Each component of the application (candidate, career development plan, research plan, mentor/environment) was equally important. Significant flaws in one category could sink an otherwise exceptional application. 2/
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what a great thread by
@kpmueller1
, academia can be a fun and collaborative place where everyone wins
I'm wildly proud to share our FIRST Weber Lab paper, out today in
@Nature
! I want to share a story about how this whirlwind of a project came together. A 🧵 on teamwork, open science, and how far we can go when we intentionally build a culture of trust in research. 1/
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Happy to share recent work from
@SandorDanielne
@joyp_ai
@BenceDaniel2
in collaboration with the Egawa lab
@FW14B_Red5
identifying a TCF1+ CD4 progenitor that maintains long term responses to chronic antigen
BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen
#biorxiv_immuno
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from Theo Roth and co!
Non-viral intron knockins enable simplified and flexible targeting of endogenous genes
Non-viral Intron Knockins Enable Simplified and Flexible Targeting of Endogenous Genes
#biorxiv_bioE
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It took several years, but we now report that ZBTB46 is a specific marker for classical dendritic cells and dendritic cell tumors in humans!
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Awesome milestone for
@Immunaitech
! Proud of the innovative and multi-disciplinary team and partnerships that we have built spanning AI, immunology, genomics, and cancer
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@theNCI
Generally, the reviewers were quite optimistic, and in cases where a resubmission was recommended, they spelled out exactly what should be addressed. Resubmitted applications that directly addressed all of the previous critiques were almost always viewed favorably.
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The immune system does everything. Really fantastic paper from
@DrShrutiNaik
Our very first paper lead by
@KoniecznPiotr
@YUEXING_1
and
@IkjotSidhu
uncovering a novel role for il17a in controlling hypoxic adaptation. A labor of love that spans nearly four years!!!
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Papers are best viewed as conversations with the field, rather than infallible truths that should stand the test of time. Our understanding will change, but every conversation is progress. Well done
@MartinGuilliams
1/4 Time for a mea culpa. I would like to highlight a serious misinterpretation I did in the past. In 2013 we proposed CD64 as a marker to identify monocyte-derived cells based on CCR2-dependence. Because with high dose of HDM we found CD64int cells in LNs, we called them moDCs.
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