Hongxiang Fu
@HongxiangFu
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Excited to share our latest work, “KnowYourCG: Facilitating base-level sparse methylome interpretation” in @ScienceAdvances! Our computational framework enables efficient functional enrichment for DNA methylation data from diverse assay platforms https://t.co/s3su9c0dsg
science.org
KnowYourCG is a scalable, CpG-based framework for DNA methylome interpretation for broad biological and technical links.
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Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team!
nature.com
Nature - DNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription...
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DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with @zhouwanding lab. Kudos to Chin Nien Lee @ChinNLee2021 and Hongxiang Fu!
biorxiv.org
The spatial resolution of omics dynamics is fundamental to understanding tissue biology. Spatial profiling of DNA methylation, which is a canonical epigenetic mark extensively implicated in transcr...
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New paper: we developed Methylation Screening Array (MSA)–a scalable tool to dissect DNA methylation in large cohorts. By profiling 5mC & 5hmC, we uncover trait- and cell-type-specific cytosine mod signatures across tissue, aging. https://t.co/ofk7QZLO74
#Epigenetics #EWAS #5hmC
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Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA methylation
pubmed.ncbi.nlm.nih.gov
Influenza virus infection alters the promoter DNA methylation of key immune response-related genes, including type-1 interferons and proinflammatory cytokines. However, less is known about the effect...
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