Beneath Earth's glaciers and ice sheets lies an aquatic realm where ice, water, rock, and microbial life interact, driving chemical reactions that can collectively influence the global carbon cycle,...

Genomes encode the instructions for life, yet their full interpretation requires models capable of capturing long-range context and functional meaning at scale. Existing genome language models (gLMs)...

Salmonella Typhimurium is a major zoonotic pathogen, with pigs acting as important subclinical carriers. To explore the specific intestinal immune response at the cellular level, we used Single-cell...

Space exploration presents tremendous health challenges. Here, we report time series of multi-omic and phenotypic profiles of seventeen astronauts from six China Manned Space missions with continuous...

Enterovirus A71 (EV – A71), a neurotropic member of the Picornaviridae family, comprises seven recognized genogroups (A – G). Despite prior identification of D and G genogroups in India, comprehens...

Genome-wide association studies (GWAS) often analyze one trait at a time, but multivariate GWAS can increase the power by leveraging trait correlations. However, existing methods struggle with high...

Gonipterus species, or Eucalyptus snout beetles, are defoliators that damage Eucalyptus trees in plantations globally. The Gonipterus sp. n. 2 genome was sequenced using both Oxford Nanopore and...

Distinguishing self from non-self is a major challenge for the immune system. Endogenous cytoplasmic double-stranded RNA (dsRNA) can mimic viral RNA and activate immune sensors like MDA5. ADAR1-med...

Borrelia burgdorferi sensu lato bacteria are the causative agents of Lyme borreliosis, a multisystemic illness with an expanding epidemiology in temperate areas. Genomic studies on Borrelia are...

Background- Klebsiella pneumoniae , known to acquire antimicrobial resistance genes (ARGs) through horizontal gene transfer, possess type I CRISPR-Cas systems. This study investigated the association...

RNA Polymerase II (Pol II) transcribes all protein-coding and many non-protein coding genes in the genome. Pol II transcription termination is crucial for mRNA maturation and, when disrupted, can...

The Type VI secretion system (T6SS) is a major determinant of bacterial competition, yet its dissemination across lineages remains unclear. Analyzing 43,213 plasmids and 29,161 chromosomes, we reveal...

The centromere of the eukaryotic chromosome is necessary for the accurate segregation during cell division. Yet, centromeric DNA is highly variable and rapidly evolving. In fungi, centromeres range...

An ideal fishery stock assessment requires a comprehensive understanding of population structure across landscapes. In the Gulf of St. Lawrence and the Laurentian Channel (GSL-LC), massive Sebastes...

Spatial transcriptomics (ST) provides high-dimensional gene expression profiles together with spatial coordinates, enabling the reconstruction of tissue architecture at cellular resolution. While...

The long-term persistence of obligate asexual lineages represents one of the most enduring and critical paradoxes in evolutionary biology. Sexual reproduction, through meiotic recombination and...

Meiotic drivers achieve biased transmission to the next generation, often at the expense of their host. Drive is widespread in nature and can shape the evolution of genomes and species. Many drive...

Viral transcriptional regulators (vTRs) reprogram host gene regulatory networks to promote replication, persistence, and immune evasion. Despite the identification of hundreds of vTRs in human...