Are you using 5xFAD mice to study Alzheimer’s disease? Our work @NeuroCellPress may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11) https://t.co/ykg48zcalG

Lymphoid gene expression supports neuroprotective microglia function @nature https://t.co/fQFs9faxl7

Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease:

A PSEN1 variant in a father and son with early-onset Alzheimer’s abolishes γ-secretase activity. What explains their dementia? @VIBLifeSciences https://t.co/Ny2K43mpbP

Stoked to see this essay on the involvement of the white matter in Alzheimer’s disease published and @ConstanzeDepp being one of the finalists for the Eppendorf & Science Prize for Neurobiology this year! 🎉 https://t.co/s9InjS2ZHG

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @ImmunityCP offers some hints. https://t.co/QBUdWljXhY Congrats @fngruqng2, @LenaSpieth, @LuLiu_Laura, @StefanBerghoff, @vinitiwari1 et al.

The ‘‘inactive’’ X chromosome (Xi) is active. Xi regulates gene expression from the active X. 1/n

Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! https://t.co/AYnP0sCbGj

Cells and blebbisomes photographed through a microscope by Burnette Lab graduate student, Grace Ward. Actin filaments are shown. #CellBiology

Oligodendrocyte precursor cell-specific blocking of low-glucose-induced activation of AMPK ensures myelination and remyelination

Testing some new antibodies to identify oligodendrocytes 🟣, for me, the most difficult one to target in brain microscopy! Here, I was able to identify its nuclei but not the whole cell body like neurons 🟡or microglia 🔵. Still, you can see oligos are everywhere! #Neuroscience

Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation

Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function ⁦@WashUMedADRC⁩ ⁦@RCFNeuro⁩ ⁦@AFTDHope⁩

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice https://t.co/eZsHUGa5Yq

The Lipid Brain Atlas is out now! If you think lipids are boring and membranes are all the same, prepare to be surprised. Led by Luca Fusar Bassini with Gioele La Manno's lab, we mapped membrane lipids in the mouse brain at high resolution. https://t.co/q3AeqGsIS1

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes https://t.co/ijOJ6lzv8Y @alzdemjournals

#GUTImage from the paper by @MelaNeurobio from @_ibima and @InfoUMA entitled "Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis" via https://t.co/3CAbo7m8Zf #Microbiota #Obesity

Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors: Cell Stem Cell

The accepted dogma for dietary lipids was their absorption by the gut lining into our bloodstream. It turns out there's another way in, via our immune cells, influenced by the gut microbiome (as shown in mice) @ScienceMagazine https://t.co/Knvh8g9BjM https://t.co/15UXOG7tAI

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport | Signal Transduction and Targeted Therapy

Presented our work at the Glia Congress 2025 a few months ago on the topic of oligodendrocytes in Alzheimer’s disease and was awarded the stipend! Many thanks to the organizers and grateful for the wonderful discussions with old and new connections.