Fun collab that we thought up over drinks after our RiboTag paper/data ( https://t.co/f9mE55pE2E). System works but not perfect since Cx3cr1 labels other myeloid cells, but most in brain are microglia (and we see the same “DAM” signature as others). Erik’s lab did the hard part!

Hugely important work from ⁦@zenbrainest⁩ that opens new doors (and immensely complicates the picture!) The polypharmacology of psychedelics reveals multiple targets for potential therapeutics: Neuron

Neurons looked most impacted in this data, but most likely because there are more neuronal nuclei in snRNAseq data

Fun collaboration with @OlneyKimberly and @vivekenigma

Sometimes you have to live with PMI, but using a well controlled system (mouse model of Alzheimer’s disease) allowed us to attribute effects solely due to PMI. Surely the brain is not unique here, but curious whether others have tried similar analyses in other tissues.

We’ve always wondered if PMI leads to changes in snRNAseq data (spoiler: it does). So, we did the study and decided to publish it for others to consider. Post-mortem interval leads to loss of disease-specific signatures in brain tissue

Makes you wonder what they’re measuring/publishing…

It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

A fun podcast I did with Karie Dozer on our new Center for Accelerated Nanotherapeutics at TGen where we will harness the power of llamas/alpacas to hopefully treat many maladies. Hope it is accessible to a broad audience. E78:The Power of Nanotherapeutics

Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal -synapse number and maturation -seizure susceptibility and hippocampal-prefrontal cortex coherence -segregation of inputs into the lateral geniculate nucleus -neuronal and astrocytic gene expression https://t.co/C6FBRqwwMA

Potential game changer in how we vaccinate against…everything!

Really nice sleuthing from some Northwestern students. I wonder how many of these exist? At least dozens. Agree we need coordinated operations against these. Hidden hydras: uncovering the massive footprint of one paper mill’s operations – Retraction Watch

@ndosenbach and I founded @TuringMedical to turn two decades of advanced MRI collaboration and friendship into real-world impact. We handed the keys over to the incredible team @TuringMedical and they are bringing that vision to life. Huge congrats on reaching this milestone! 👇🏾

Lots to unpack in this really cool work by @Da_Mesquita_S lab! Not just for brain lymphatics nerds!

I feel like the name is close enough that they should name those panda babies Salt and Shaker. Giant panda Ying Ying gives birth to twins : NPR

This continues to be a problem for research. What’s in a picture? Two decades of image manipulation awareness and action – Retraction Watch

So sad to hear about the passing of Carl Cotman. He published countless seminal works and is an icon in the field.

If you’ve not seen this paper yet and you do sc/sn-RNAseq, stop and go read it now! Comparative Analysis of Commercial Single-Cell RNA Sequencing Technologies | bioRxiv

Super legit lab doing tons of cool work!

This was a fun project to collaborate on. We played a small part, but the data is so interesting. Please explore!