Janos Groh
@GrohJanos
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Neurobiologist interested in myelin, inflammation, and degeneration of the diseased and aging nervous system.
Würzburg, Munich
Joined February 2021
Now published in the June issue.@NatureNeuro. I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover. #Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple. Thanks @ElisaFlo04 & co!.
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RT @AllenInstitute: When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function. New stu….
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RT @vinitiwari1: Happy to share this review article published in @RockUPress @JExpMed today. Thankyou Mika and @Lucie_JExpMed for the oppor….
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RT @alzforum: Are T cells in the brain friend or foe? In tauopathy mice, CD8⁺ T cells can slow pathology. In older, wild-type mice, they da….
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RT @vizgen_inc: New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cel….
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RT @LukensJohnR: Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and m….
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See also this excellent News & Views from Jonathan Monteiro and Veronique Miron.
nature.com
Nature Neuroscience - Aging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on...
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Pleased to share our latest work on neural-immune interactions in aging white matter. It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations. Many thanks to everyone involved.
nature.com
Nature Neuroscience - White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell...
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RT @NeuroCellPress: To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by @AGuskjole….
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Happy to share this recent review with Mika Simons - White matter aging and its impact on brain function: Neuron
cell.com
Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes...
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RT @Cell_Mama_: My first-author paper is out today @NatureComms ! We investigated how oligodendrocytes produce myelin. Using volume EM, we….
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RT @GregDuncs: I am excited to announce our work on how myelin loss culminates in neurodegeneration has been publi….
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RT @LenaSpieth: 🚨NEW PAPER ALERT 🚨 Our paper just got published in @ImmunityCP ! From Munich with 🥨 Check it out here: .
cell.com
Pathogenic protein aggregation drives Alzheimer’s disease, but how it is initiated remains unclear. By generating a APOE-HaloTag knockin mouse model and optimizing APOE purification techniques, Kaji...
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RT @vinitiwari1: 🎉Excited to share that my PhD work is out @ImmunityCP. We show that epigenetic reprogramming via innate immune training wi….
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RT @NatureNeuro: In a mouse model of #Alzheimer’s disease, amyloidosis itself triggers age-related #oligodendrocyte and #myelin damage medi….
nature.com
Nature Neuroscience - The involvement of age-related myelin damage in Alzheimer’s disease is unclear. Kedia et al. show that T cell-mediated microglia activation triggers a response against...
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RT @ManuelFriese: Proud to present our findings in @CellCellPress about neuronal STING as integrator of inflammatory and glutamate signals….
cell.com
Inflammation and glutamate excitotoxicity are the major drivers of neuronal cell death in multiple sclerosis (MS). This study identifies neuronal STING as a central regulator of inflammation-induced...
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RT @Cell_Mama_: I’m going to present a poster in ASCB/EMBO this year. Stop by if you want to know about oligodendrocyte, one of the most po….
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Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease.
nature.com
Nature Communications - Despite being implicated in several neurological diseases, the gut-brain axis remains poorly understood. Here the authors describe a mechanism of communication between the...
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Please check out the final version of our recent work on #myelin disease, neuroinflammation, and axon degeneration Thankful for a very constructive review process @NatureComms and amazing help @Lab_Coleman @AE_Saliba @Uniklinikum_Wue @SyNergy_Cluster et al.
nature.com
Nature Communications - Demyelination is often suggested to cause axonal degeneration. Here, the authors study mice carrying distinct PLP defects and reveal how persistent ensheathment with...
Happy to share our new preprint on #myelin disease:.
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