Darshan Sapkota
@darshan1s
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Keywords: New PI, mRNA translation, Brain homeostasis, Neurological disease, JJ Cale, Mark Knopfler, George Harrison.
United States
Joined April 2016
Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! https://t.co/AYnP0sCbGj
nature.com
Nature Neuroscience - Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and...
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I'm excited that @Jjiyeon_lee's 2nd paper from the lab is out in @NatureAging. We found that the circadian gene REV-ERBalpha regulates brain NAD+ by controlling CD38 in astrocytes. REV-ERB KO or pharmacologic inhibition mitigates tau pathology in mice.
nature.com
Nature Aging - Lee et al. show that the circadian clock protein REV-ERBα controls brain NAD+ levels by regulating the NAD+-consuming enzyme CD38. Global or astrocytic REV-ERBα deletion or...
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Spatial transcriptomics and sex-differential expression analyses in the human ventromedial hypothalamus and arcuate nucleus are preprinted! Come hear more Wednesday at #ACNP2024, poster W 189! @kr_maynard @martinowk
biorxiv.org
The hypothalamus contains multiple regions, including the ventromedial hypothalamus (VMH) and arcuate (ARC), which are responsible for sex-differentiated functions such as endocrine signaling,...
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Btw. @DjuranovicLab will be Djuranovic lab at Brown University and newly formed RNA Center from July 1st 2025. Postdoc as well as staff scientist positions will be available, please apply. https://t.co/4IObhKdiE0
brown.edu
The ambitious goal of the new Brown RNA Center is to untangle the mysteries of human RNA, which could be instrumental in preventing and developing treatments for a wide variety of complex diseases.
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I'm excited to announce that Jennifer Lawrence's thesis work is now out! Check it out here: JCI Insight - Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown
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Biol Sci at UT Dallas is hiring 4-5 Asst Profs, at least 1 each in biochem, cancer biol & neurosci. The startup is robust, salary is hard $, and core facilities are stellar. Happy to answer questions as a search committee member. Pls apply here. Thanks!
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Very excited that our astrocyte & microglia circadian atlas preprint is out! Congrats to @Patwsheehan on this awesome work, and thanks to @joeddougherty @darshan1s and especially @johnthefryer! If you study glia, AD, aging, circadian, check it out! @SRBR_Outreach @ResearchSleep
My final paper from my PhD with @ErikMusiek is now on biorxiv! We asked if microglia and astrocytes have the ability to change which genes are expressed in rhythmic manner during Alzheimer's pathology and during normal aging.
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Maximizing Access to Research Careers
impact.utdallas.edu
Help The University of Texas at Dallas raise $2,000 for the project: Maximizing Access to Research Careers. Your gift will make a difference!
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Congrats to Dr. Kelli Palmer and her team who received a $3 million federal grant to investigate how lipids help disguise the bacterium from immune cells and make infants susceptible to sepsis and meningitis. @MorcosLab @UTD_Biology @UTDScience 🔗 https://t.co/noSgbcDOcP
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Happy to share the first preprint from the lab! Led by @SharonKwende and made possible by the contributions of @nutellachapati @jacqulenesingh @subhajitmaity97 Dun Ning, Grant Shryock, Zhenyu Xuan @UTD_Biology @UTDScience and @AACR funding😊
Obesity modifies cell fate plasticity of Pdgfrα-expressing mammary adipocyte progenitors to promote an aberrant mammary microenvironment https://t.co/foFN4B64Sw
#bioRxiv
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Our preprint is out! @connor_maltby used CANVAS patient iNeurons to interrogate how AAGGG repeats in RFC1 cause neurodegeneration. Findings suggest repeat removal but not RFC1 replacement corrects phenotypes -pointing way to a potential therapy. #Ataxia
https://t.co/a2L3PC2NpV
biorxiv.org
Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a late onset, recessively inherited neurodegenerative disorder caused by biallelic, non-reference pentameric AAGGG(CC...
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My dept (Biol Sci at UT Dallas) is hiring faculty members at all ranks. It's an awesome place, full of young investigators and excellent core facilities. You will prosper here. Pls let me know if you have any questions.
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UT Dallas @UTD_Biology @UTDScience has multiple tenure-track faculty positions open! It is a great place to build your research program. We have excellent students, core facilities, research support and multidisciplinary collaborative opportunities!
We have multiple openings for tenure track faculty (Assistant, Associate, Full) in our department @UTD_Biology. Please RT and encourage your colleagues to apply!
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We are looking for a postdoc!! Do you love microbiome research? Are you passionate about using interdisciplinary approaches to improve Women’s Health? Do you want to work in a supportive, trainee-focused environment? If so, then come join us! DM me w/ Qs!
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Sick of how long MIC testing takes? Wish you could set it up 800% faster while maintaining its high accuracy? Let me introduce you to HT-MIC, a new robotics MIC workflow designed by Suman Tiwari @sumantiwari921 with help from Oliver Nizet @OliverNizet. https://t.co/ib1Fj0CaKv
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Very happy to finally present my PhD paper in the Musiek lab where we find astrocyte activation via loss of Bmal1 abrogates intra-neuronal tau/synuclein pathology! We also find Bag3 upregulation in a cluster of astrocytes in human AD patients that resemble DAA astrocytes! 👇
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Interested in recording epigenetic states in the brain over time? Step by step instructions (and software) from the inimitable Allen Yen of @CarpeRibosomam are live here: https://t.co/5efTF3Hjyw And if you are at Brain Iniatiative meeting come find him (or me) at the posters!
biorxiv.org
Calling Cards is a platform technology to record a cumulative history of transient protein-DNA interactions in the genome of genetically targeted cell types. The record of these interactions is...
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Local translation occurs in peripheral #microglial processes (PeMPs) in mouse brain, and plays a role in phagocytic cup formation New from @joeddougherty @jurassicvasek @CarpeRibosomam @sarah_koester4 @TristinaLi_Lab @DeajonJelani @jiwonyi2 et al. https://t.co/WRR8x9mSXB
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We’re hiring! Projects combine genomics, in vivo ephys and synaptic physiology to understand how plasticity in basal ganglia circuits give rise to maladaptive decision making- with a focus on models of substance use disorder and chronic pain! (1/n)
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Congrats to @CeliaMcKee on her exciting work on astrocyte lysosomal regulation by BMAL1, out in @PNASNews! Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes | Proceedings of the National Academy of Sciences
pnas.org
An emerging role for the circadian clock in autophagy and lysosome function has opened new avenues for exploration in the field of neurodegeneratio...
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