Characterization of the circadian translatomes of astrocytes and microglia in mouse cortex in the setting of amyloid pathology or aging, revealing cell and disease-specific circadian reprogramming of neurodegeneration-related pathways @ErikMusiek @johnthefryer @patwsheehan

Resetting the body’s rhythm could protect the brain from Alzheimer’s

Medicare takes money from your paycheck your entire life and in return you get Part A, which covers some of the cost if you’re hospitalized. You’re still on the hook for some out of pocket expenses. If you want to see a doctor, you better have part B, for which you need to

ARE YOU KIDDING ME?! 🤯 Jane Hedengren of @BYUTFXC OBLITERATES the competition at the Big 12 Cross Country Championsip, running an astonishing 18:29.6 course record for 6km to lead BYU to the team title with 38 points. https://t.co/vKpN8mxpVj

Octopuses really have super powers, why is everyone casual about it?

One advantage of having many distinct sovereign nations instead of a single world government is that they can try different policies and we can see which work best.

We’re not crying, we promise 🥹🥲 Yaroslava Mahuchikh broke a 37-year-old World Record at the #ParisDL #DiamondLeague

Advocating socialism is a luxury paid for by the successes of capitalism.

A nice article in @washumedicine about our recent paper: https://t.co/WJWrHe729v

Super happy to see my last paper from the Musiek Lab @ErikMusiek in its final form. We previously described the paper when we added it on biorxiv (also posted below). Essentially, we profiled the circadian translatome of astrocytes and microglia in vivo in healthy, aged, and mice

Turns out that the time of day that you harvest your mice has a significant impact on what DEGs you will find. Anyone interested in AD, brain circadian rhythms, astrocytes, microglia, or brain aging, can look up their favorite genes on our website: https://t.co/6qJdsdIxlU

More than half of all Alzheimer's GWAS genes were rhythmic in the brain, mostly in microglia! Many microglial reactivity/DAM genes were rhythmic, as was microglial amyloid plaque phagocytosis in vivo.

We used TRAP/RiboTag to profile whole brain, astrocyte and microglial gene expression across a circadian cycle (in DD). We found that different cell types in the brain have unique circadian "translatomes" which are reprogrammed in specific ways by amyloid pathology or aging.

Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! https://t.co/AYnP0sCbGj

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 ⁦@WashUMedADRC⁩ ⁦@alzassociation⁩

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! https://t.co/J5HekY1Pc0

Please join us via Zoom this Friday, Oct. 17 at noon Central time for @WashUcobras Seminar Series with Dr. Daniella Noain from University Hospital Zurich! Just DM me for the Zoom link.

I’m turning 41, but I don’t feel like celebrating. Our generation is running out of time to save the free Internet built for us by our fathers. What was once the promise of the free exchange of information is being turned into the ultimate tool of control. Once-free countries

I had a fun time talking with Dr. Mark Mattson on his Brain Ponderings podcast about our lab's work on circadian clocks and neurodegeneration. https://t.co/wopILpPJ3V

Happening today at noon central!