Dylan Burnette
@MAG2ART
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Cell biologist studying how a heart grows and dies; also Blebbisomes. Associate Professor at Vanderbilt. Married to @gillianhoo.
Nashville, TN
Joined January 2015
I am excited to finally be able to share with you our work reporting the first Extracellular Vesicle with a personality! This video does not show a cell, it is a Blebbisome! #CellBiology
https://t.co/ABCCCZ5fPp
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I am presenting at the Science and Art Minisymposium at #CellBio2025 today! The line up is great this year. I am hands down the least qualified person presenting. It is a weird feeling but I am excited! Here is my title slide. Room 122 4pm
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The movement within a nucleus is crazy! This movie of a cell's nucleus videoed through a DIC (transmitted light) microscope shows 30 seconds of movement in 8 seconds. #CellBiology
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Todas nuestras células sanguíneas, incluyendo las del sistema inmunitario comienzan con una sola célula: célula madre hematopoyética pluripotencial. 👇🏼
🔥 Your entire immune system starts with one cell. Every red blood cell that carries oxygen Every platelet that stops a cut from bleeding Every neutrophil that attacks bacteria Every T cell that hunts viruses Every B cell that makes antibodies All of them come from the same
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A monolayer of heart muscle cells dying in a culture dish videoed through a microscope. Purple shows the nucleus of each cell. A nucleus turns green when a cell dies. #CellBiology
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Today’s alpha-actinin-4 (ACTN4) plot twist: Based on our non-muscle myosin II work, we expected ACTN4 loss to reduce sarcomere assembly. Instead, ACTN4 depletion produced the opposite; more sarcomeres and cellular hypertrophy. Sometimes biology says, “Try again.” #CellBiology
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¿Qué vemos en la imagen? No es 'Cookie Monster', son células del músculo cardíaco en donde se observan los cromosomas condensados en la metafase del ciclo celular. Hermosa, ¿no? 🤩🔬 ©️ @MAG2ART y Dr. James Hayes. Fuente: https://t.co/giQ6KYW9X9
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ACTN4 isn’t just hanging around the Z-disc in heart muscle cells. AlphaFold3 predicts it forms heterdimers with muscle ACTN2. And the pull-downs agree: ACTN4 brings down ACTN2 even when actin is out of the picture. #CellBiology
https://t.co/OQ4tj9R8xW
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Today’s data drop from our alpha-actinin-4 paper! 1A: Cardiac myocytes don’t just express muscle alpha-actinin (ACTN2)… they also express ACTN4; a “non-muscle” paralog. 1B: ACTN4 is sitting right at the Z-disc, shoulder-to-shoulder with ACTN2. https://t.co/OQ4tj9RGnu
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"Non-Muscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling" is now online at Circulation Research! Congratulations to Dr. James Hayes on this ambitious work! There is a lot in the paper so let's start with the graphical abstract. @CircRes
https://t.co/OQ4tj9RGnu
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Some cells are just in it for the drama! The bottom 5 microns of cells videoed through a microscope by @EmmaKoory. The middle cell rounds up (for fun?) and subsequently rounds up to divide. We missed so much of the action by just sampling the bottom. @CellBiology
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Un migrasoma es un orgánulo celular que se produce durante la migración celular y cuya biogénesis depende de este proceso. Se genera en diversas células: inmunitarias, tumorales metastásicas, otras células con funciones especiales como los podocitos y las de organismos en
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A hungry heart muscle cell (cardiac myocyte) videoed through a microscope by Burnette Lab graduate student, @EmmaKoory. What is it eating and why? We may never know....... #CellBiology
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A cell with prominent membrane blebs videoed using spinning disk confocal (left) and differential interference contrast (right) microscopy. #CellBiology
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A large extracellular vesicle called a "blebbisome" videoed through a spinning disk confocal microscope. Video dimensions: 15x15 microns. #CellBiology
https://t.co/ABCCCZ5NEX
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Been doing a lot of time lapses of iPSC-derived cardiac muscle cells lately! Here's one of my favorites. This cell is expressing fluorescent alpha-actinin-2 and the colors represent depth. Movie length = 24h with frames taken every 20m. #microscopymonday #cellbiology @MAG2ART
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Membrane blebs on a cancer cell videoed through a DIC microscope. What are blebs? Intracellular pressure within the cell blowing up tiny balloons using the plasma membrane. Or something like that. #CellBiology
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iPS cell-derived cardiac myocytes (heart muscle cells) typically beat about once per second, so I usually speed up the movies I post; otherwise, scrollers might miss the action. But every now and then, a cell looks like this in real time. Could we use these rare cells to uncover
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Beating iPSC-derived heart muscle cells videoed through a microscope. Alpha-actinin-2 is shown. #CellBiology
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An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, @EmmaKoory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.
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