New biomarker for CAA? CRIP1, a vascular protein, tracks with CAA severity, shows up in CSF, and may seed amyloid aggregation. A genetic variant also decreases a person’s risk for #alzheimersdisease. @EmoryMedicine

To turn obese mice into trim ones, Tenvie’s NLRP3 inhibitor enters the brain, where it cools down an inflamed hypothalamus.

@WatcherGuru This is what happens when you fire the humans and have AI run your IAAS.

Three early-phase trials find that transplanting stem cells into the brains of people with Parkinson’s disease appears safe and may improve motor symptoms. @MSKCancerCenter @KyotoU_News @yonsei_u

A screen of transcriptional regulators identified 18 that control microglial activation states found in #alzheimersdisease brain. @UCSF

Using multi-omics, cell, and mouse studies, scientists propose that gut microbial metabolites alter chromatin structure and RNA splicing in the brain. @Stanford

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Scientists have grown brain organoids for five years in culture. The cells mature at a similar pace to those in the developing human brain. @broadinstitute

Large-scale proteomics study of the Alzheimer’s hippocampus uncovers pathogenic protein operatives, including the astrocytic scaffolding protein, AHNAK. @IcahnMountSinai

Scientists have armed circulating immune cells with tau-destroying aptamers. In mice, these cells crossed the BBB, cleared tau, calmed inflammation, and improved memory. @CAS_Science

Analysis of 2,603 structural MRIs showed the brain does more than shrink with age, it reshapes. Regions along the inferior-anterior axis expand while the superior-posterior axis compresses, and these shifts track with memory and cognitive decline. @ULL

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Altered splicing directly accounts for only 10 percent of proteins perturbed by TDP-43 loss. Gene-expression changes and downstream effects account for the rest. #amyotrophiclateralsclerosis #frontotemporaldementia @UMich @MIT

For the first time, researchers have spotted nanotubes linking neurons in the mammalian brain. These thin bridges shuttle Aβ between cells and increase during early amyloid buildup in Alzheimer’s mouse models. @HopkinsMedicine

Scientists debut the Neurolipid Atlas, a data resource to study how lipids factor into neurodegenerative disease. They start with some insight on cholesterol esters in ApoE4 astrocytes.

Common neuropathologies explain only half of the protein changes in plasma during cognitive decline. #alzheimersdisease @EmoryMedicine

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Walk through the Alzforum portal to free, annotated histological images of neurodegenerative disease pathologies, curated by neuropathologists at LMU. This visual learning tool can help in the lab, publications, and the classroom. @LMU_Muenchen

Synuclein sinkholes snare lysosomal repair proteins. Without them, lysosomes leak, spilling synuclein seeds into the cytoplasm. Does this speed up pathology? @MPI_Biochem

Whether by soccer or American football, repeated blows to the head knock out neurons nestled within the folds of the brain, and strain cognition. @BU_Tweets @Columbia

Study finds microglial aging is driven by the brain microenvironment rather than the cells themselves. Rather than replacing cells, resetting microglial pathways could slow brain aging. @calico

The DSA is behind Mamdani and the takeover of the Democrats. Who are they? Meet Sidney Carlson White - Seeks to destroy the U.S. "Fight American Empire. Struggle for socialism. Demand a new democratic republic!" - "The NYPD is a colonial army that must be defunded" - "Russia

The rare APOE3 Christchurch mutation may shield against Alzheimer’s by rerouting toxic tau into astrocytes for clearance. @ucsantabarbara

Two studies show off tau-binding chimeras: one a protein, the other a small molecule. Both lower pathology in tauopathy models. @CUBoulder @SeoulNatlUni

TDP-43 may play a role in neurodegenerative disorders such as #alzheimersdisease and #parkinsonsdisease, even in the absence of detectable aggregates. @UKDRI @Cambridge_Uni @WeizmannScience @EmoryMedicine