In Japan, China, and South Korea, clinicians report few problems with lecanemab treatment, finding ARIA-E rates of 3 percent to 4 percent. #alzheimersdisease

The ALZ-NET clinical registry has 3,648 participants and enrolls about 50 new amyloid immunotherapy patients per week. #alzheimersdisease @UCSF @USC

Our Dialog Over U.S. Air Traffic Control System Modernization Has Reached a New Low Flying Magazine reports that when FAA Administrator Bryan Bedford was questioned by House Representative Hank Johnson about the rationale behind the selection of Peraton as the FAA’s system

Data from CTAD 2025 suggests that Roche’s γ-secretase modulator Nivegacetor is just as safe and effective in the Paisa kindred that harbors a mutation in the drug’s target enzyme. @Roche

Postmortem brain reveals that aducanumab had cleared plaques and lessened tau pathology but increased vascular amyloid. #alzheimersdisease @MassGeneralNews

Semaglutide doesn’t treat Alzheimer’s, but some think it could prevent AD or other dementias if started earlier. @NovoNordiskUS

Agentic AI is only as strong as the search foundation beneath it. At AWS re:Invent 2025, @NickPatience and @elastic’s GM of Search Solutions, Steve Kearns (@skearns64), break down how enterprises are moving from classic RAG to autonomous, production-grade agentic systems—and how

At CTAD, WashUs Bridget Phillips reported that certain circular RNAs in the blood might be a warning sign of impending Alzheimer’s.

In a Phase 1 trial presented at #CTAD25, the Aβ vaccine AV-1959R provoked strong antibody responses against Aβ aggregates in all recipients.

New role for an old tuberculosis vaccine? Five-year Phase 2 data suggest BCG resets Alzheimer’s-linked proteins and improves key biomarkers in cognitively healthy adults. @MassGeneralNews

New data from CTAD 2025 suggest that the shingles vaccine may protect against dementia, MCI, and even dementia-related death—evidence seen in the UK, Australia, and now Canada. @Stanford

People assume that once they've set up a digital asset LLC, they've handled the legal side of their crypto holdings. The LLC is doing its job. It's protecting you from liability, maybe giving you some tax flexibility, keeping your personal assets separate from your crypto

At CTAD, scientists reported that the FDA-cleared Fujirebio Lumipulse p-tau217/Aβ42 blood test for #alzheimersdisease returns many false positives. The company is investigating. @MayoClinic @CTADconference

Lipid profiles differ between symptomatic AD, asymptomatic AD, and healthy controls. One lysophospholipid looks like a promising AD marker. @UTSWNews

In people with AD, tau tangles found within the touch-sensing stations of the spinal cord might explain loss of tactile sensitivity. @2024_HUST

Scientists identified 49 proteins genetically linked to cerebral small vessel disease. This common co-pathology with #alzheimersdisease contributes to risk for ARIA. @wustl @UTokyo_News

Come meet the most famous trader on Wall Street! @EinsteinoWallSt will be at the Diplomat Hotel. Jam 29-Feb 1.

Introducing Kosmos, an AI biomedical scientist that polishes off six months of human work overnight, making AD-relevant discoveries. @EdiSci

New research identifies inflammatory, C5aR1-positive microglia as potential drivers of the swelling that follows traumatic brain injury.

A new method for detecting genetic variants that disrupt RNA splicing has revealed the function of an Alzheimer’s risk allele: It drops exon 7 from the MS4A3 gene. @PennMedicine

In microglia, blocking formation of cholesteryl esters boosts release of sTREM2, which drives Aβ uptake. #alzheimersdisease @MassGeneralNews

The coming years will split companies into two groups: those that become AI-native and those left catching up. The innovators who harness AI now will define the winners of tomorrow. Follow me for strategic insights on leading through the AI revolution.

Does the Alzheimer’s risk gene INPP5D make lysosomes leaky? In iPSC-microglia, lowering its expression may cause the cells to spill their proteases into the cytosol and spark inflammatory signaling.

Study shines light on the “dark genome” of Alzheimer’s. Long-read sequencing uncovered retrotransposon activity near risk genes and methylation shifts in repetitive DNA, revealing new genetic instability in AD. @BrownUniversity

A modeling study finds that once aggregation of α-synuclein or tau overwhelms cellular removal machinery, runaway aggregation ensues. @Cambridge_Uni @SceinceStowers