ElowitzLab
@ElowitzLab
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Lab of Michael Elowitz at Caltech. Synthetic biology and systems biology
Los Angeles
Joined December 2013
Congratulations @ShiyuXia and @ucberkeley!.
In January 2026, I will be joining Berkeley @UCBerkeley as an Assistant Professor in the Department of Chemical and Biomolecular Engineering, College of Chemistry @UCB_Chemistry, with exciting connections with world-class communities including the Lawrence Berkeley National
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RT @ma_yitong: Added some tiny improvements to the flowcytometry app I made during my time in @ElowitzLab. Now it supports exporting gated….
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This work was led by brilliant students: @andreww_lu, @lkmoeller, and Stephen Moore, and is a collaboration with @Zhu_Lab and @DJSiegwart. If you have experience in animal cancer models and are interested in circuit therapeutics, please reach out.
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In a mouse model of Ras-driven liver cancer, systemic treatment with the circuits (lower row) reduced tumor burden compared to untreated controls (upper row). Much more to explore.
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We compared circuits (right) with Ras inhibitors (RMC-7977 and Sotorasib) by targeting mutant cells (magenta) co-cultured with wild-type Ras cells (green). Circuits were potent and selective.
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We tried many, many, many circuit designs, eventually generating ones that sensitively discriminate Ras mutant cancer cells. We also generated protease-activated proteases to amplify weak oncogenic signals.
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Why therapeutic circuits?.Sense-and-kill ≠ inhibit. Oncogene inhibition indirectly induces cell death, but is susceptible to resistance through compensatory signaling. Circuits directly rewire oncogenes to cell death --> less chance of resistance. Other benefits as well.
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In this paradigm, engineered proteins are introduced into cancer and healthy cells using LNP-delivered mRNA. They then sense cancer markers (such as mutant Ras) and trigger engineered cell death effectors (caspases or gasdermins) only in cancer cells. (idealized schematic)
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Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
biorxiv.org
Many targeted therapies indirectly suppress cancer cells by inhibiting oncogenic signaling pathways such as Ras[1][1]–[4][2]. This renders them susceptible to resistance and limits their long-term...
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Beautiful paper from @sandynandagopal , Galit Lahav & colleagues. a seemingly “messy” circuit of dimerizing proteins (bHLH factors) can process a combinatorial input signals. Important step in more systematically understanding biological signal processing.
How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out:
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I just love the great writing, beautiful books (and now. the capsule!) that @NikoMcCarty and others at @AsimovPress are creating.
Our second book is now available for pre-order. 🎉. Embracing the book's technology theme, we did something special:. We encoded the entire book into DNA & packaged it into stainless steel capsules, where it will live for tens of thousands of years. 1,000 copies were made. 🧵
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RT @schmidburgk: How could we identify key genes involved in any biological process and cell type? Please read on about Nuclear In-Situ Seq….
nature.com
Nature Biotechnology - An optical pooled screening method can correlate phenotypes and perturbations in any nucleated cell type.
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RT @NatureRevGenet: The lives of cells, recorded #Perspective by @AskaryLab, Wei Chen, @_Choi_Junhong, Lucia Y. Du,….
nature.com
Nature Reviews Genetics - Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their...
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Amazing opportunity to work with phenomenal scientist….
Join us @ArcInstitute and @Stanford Genetics! We're looking for a phenomenally talented and motivated Research Associate II to help us build synthetic biology and genomic technologies to understand and manipulate cells. Apply here!
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RT @RoyKishony: AI-Science: New features! .- Human-AI copilot app: Much more powerful (and fun) than the AI agents doing it all. - Fully an….
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RT @jeffnivala: Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing C….
nature.com
Nature - A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed...
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RT @PostdocIsrael: Attention prospective postdocs!. The Azrieli International Postdoctoral Fellowship for Research at Israeli Universities….
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RT @ItaiYanai: Top 10 Manu Prakash teachings from his amazing episode of the Night Science Podcast. 1. Science is a sense of wonder; a pers….
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RT @tranmartink: Check out this awesome work from Will — a huge step towards the dream of multiplexed long-term recording of cellular histo….
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