Adam Stevens
@stevenschem
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Assistant Professor @Penn_CBIO The Stevens Lab aims to develop cell and tissue therapeutics by applying synthetic biology to study cell adhesion and mechanics.
San Francisco, CA
Joined May 2012
I am excited to announce that in March, I will start my lab in the Department of Cancer Biology (@Penn_CBIO) at the University of Pennsylvania Perelman School of Medicine (@PennMedicine).
stevens.bio
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We are searching for computational PhDs and Postdocs to join our group in collaboration with @TreutleinLab . We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to deco_ihb@roche.com
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Happy to share that this work is now published in @BiophysJ!
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out it’s both! Excited to share the 1st preprint from my postdoc w/ @SeanMegason @SeanEMcGeary @KleinLabHMS 1/20 https://t.co/m3N06W8xRt
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📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! https://t.co/xZhuYMl5cW
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Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@CellBiomat, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : https://t.co/GSSJPePbgX
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Congratulations to the impressive list of @Penn scientists awarded @NIHDirector's high-risk, high-reward research grants! These #NIHHighRisk awards fund innovative & impactful biomedical research. Check back as we profile each winner➡️ https://t.co/FWxPpmJqLs
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Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology! Check it out! 📜: https://t.co/apDvC2TG7V Thanks to @uwnews for the feature write-up! https://t.co/3tDUmuepDD
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🚨 I'm hiring at all levels! Interested in animal origins & evolutionary cell biology? I'm recruiting a postdoc, PhD students & a research assistant to study the evolution of cell adhesion using marine inverts + comparative genomics. 🔗: https://t.co/975qBVaxGt Please repost!
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The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science. Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving 4–22% success rates with efficient experimental
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New in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out! 📜 :
science.org
Cardiomyocyte hypocontractility underlies inherited dilated cardiomyopathy (DCM). Yet, whether fibroblasts modify DCM phenotypes remains unclear despite their regulation of fibrosis, which strongly...
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New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tom_golde 🙌 @IBECBarcelona
https://t.co/HZVLYVkcde
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1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint. If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too
biorxiv.org
Understanding biological systems requires observing features and processes across vast spatial and temporal scales, spanning nanometers to centimeters and milliseconds to days, often using multiple...
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Please help get the word out - We are hiring at all levels (postdocs, grad students, and postdocs)! If you are interested in sponges, evolution, cell biology, and symbiosis, please don't hesitate to reach out and learn more about the opportunities in our lab.
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🌟Financing milestone! #SpliceBio closes $135M Series B to: 🚀Advance SB-007 for #StargardtDisease 🔬Expand our genetic medicine pipeline Read more: https://t.co/KOf1Vj7QsY
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🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? https://t.co/ejW8rpxzmW
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In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out it’s both! Excited to share the 1st preprint from my postdoc w/ @SeanMegason @SeanEMcGeary @KleinLabHMS 1/20 https://t.co/m3N06W8xRt
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The final version of our protein transposition manuscript is now published in @ScienceMagazine
https://t.co/tKuqYQwr1S We’ve added a few new things since our preprint /1
science.org
Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding...
Ever wanted to swap out an entire internal region of a folded protein for functional biochemical studies? Check out our preprint that has been 5 years in the making, in which we establish a protein editing platform via protein transposition, enabling the insertion of functional
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Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions - now available as a preprint on bioRxiv! 🎉 Huge congrats to @ernest_iu for leading the project, and a special thanks to our amazing collaborators! https://t.co/bf0zimgKHV
biorxiv.org
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin-based lamellipodia protrusi...
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This is an absolutely incredible milestone, and it has been inspiring to see Miquel and his team move this into the clinic.
📢 News alert! #SpliceBio has dosed the first patient in the Phase 1/2 ASTRA study with SB-007, the first dual AAV gene therapy in clinical development for #Stargardtdisease. Discover SB-007's potential for treating Stargardt patients in the press release below.
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BIG NEWS in @CellReports! Adhesion strength of tumor cells predicts metastatic disease in vivo https://t.co/5VpjqeEUha In this work, we show that a physical property - adhesion strength - stratifies mouse and patient samples into disease and non-disease subtypes. (1/4)
cell.com
Kane et al. show that adhesion measurements of cancer cells can be used to retrospectively predict metastatic capacity within an in vivo murine model. Additionally, adhesion can be used to stratify...
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I am extremely proud to see our work about Hepatitis B now published in @CellCellPress. From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 https://t.co/wfdbwQmw4J
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