Cole DeForest
@coledeforest
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Weyerhaeuser Associate Professor of Chemical Engineering & Bioengineering, University of Washington | Husband | Father | Outdoor Enthusiast
Seattle, WA
Joined September 2009
HUGE NEWS! In our new preprint, we introduce “grayscale image z-stack-guided multiphoton optical-lithography” (GIZMO) to rapidly photomodulate materials in full 3D non-binary patterns at sub-µm resolutions spanning large volumes (>mm3). https://t.co/5QJmZDschS Paper 🧵 (1/19)
Grayscale 4D Biomaterial Customization at High Resolution and Scale https://t.co/SnamjMqcUn
#bioRxiv
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Medicine isn’t just about finding the right therapies — it’s also about getting them to where in the body they’re needed. These new smart proteins can autonomously read bodily cues to zero in on the exact locations of diseases. @coledeforest
https://t.co/qANwLDrPLL
washington.edu
Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint precise areas of the body can reduce the medicine dosage and avoid potentially harmful “off target”...
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Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@CellBiomat, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : https://t.co/GSSJPePbgX
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Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology! Check it out! 📜: https://t.co/apDvC2TG7V Thanks to @uwnews for the feature write-up! https://t.co/3tDUmuepDD
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Thanks also to @UWISCRM for nicely highlighting the work! https://t.co/n2BjNAkfXB
iscrm.uw.edu
Multiscale analysis reveals that fibroblasts play a more active role in dilated cardiomyopathy than previously suspected.
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Mike Regnier, Farid Moussavi-Harami, Nate Sniadecki, and their respective labs also played instrumental roles on these exciting efforts!
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This has been a huge collaborative effort overseen by Jennifer Davis and driven by co-first authors Ross Bretherton (co-advised between the DeForest and Davis labs) and Bella Reichardt.
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New in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out! 📜 :
science.org
Cardiomyocyte hypocontractility underlies inherited dilated cardiomyopathy (DCM). Yet, whether fibroblasts modify DCM phenotypes remains unclear despite their regulation of fibrosis, which strongly...
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Our new manuscript entitled "PhoCoil: A Photodegradable and Injectable Single-component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation" is now live at @ScienceAdvances! Check it out here (🔓):
science.org
PhoCoil is a genetically encoded hydrogel that enables noninvasive delivery and subsequent user-controlled photodegradation.
A new study in @ScienceAdvances from @coledeforest introduces PhoCoil, a recombinant protein hydrogel with light-triggered disassembly, enabling precise spatiotemporal control of cell delivery, advancing tools for regenerative medicine + cell therapy. https://t.co/WmUzWAiBlS
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Check out our new paper entitled "Genetically Encoded Interpenetrating Polymer Networks as Injectable Biomaterials for Controlled Therapeutic Protein Delivery", appearing in @ACSBiomaterials! https://t.co/YA1fgRtD0e
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Happy Holidays from the DeForest Lab! What fun to celebrate the group’s 2024 achievements, especially in the baking sector. Our annual dessert bake-off competition was a tasty success!
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Professors often tell graduate students that “Your PhD is a #marathon, not a sprint”. Having now run the 2024 @SeattleMarathon (many years after finishing a PhD), I now actually feel qualified to make such a statement. @UWMedicine
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Happy Halloween! 👻 A patterned arrangement of photos, each of an analytical balance/scale that is colored gray? Or, perhaps... a "grayscale photopattern"? (costume inspired by our lab's recent work here: https://t.co/5QJmZDschS)
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Come be our new faculty colleague - we're hiring this year at @UWBioE! Great department, stupendous science, awesome location, and amazing people!
Calling all faculty candidates (postdocs, Asst Profs, senior grad students) - Apply to @UWBioE! Job ad at link below. If you are considering applying and have questions on the ad, please email or DM me. Come join us, UW is amazing!
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Absolutely thrilled that my recent sabbatical host, collaborator, backcountry ski partner, and friend - the one and only David Baker from the @UW @UWproteindesign Institute - for winning the 2024 #NobelPrize for "computational protein design"! What an amazing ride!
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Looking forward to working with and helping expand the @UWMolES community in this new role!
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Excited to see our latest manuscript, entitled "Light-based fabrication and 4D customization of hydrogel biomaterials" is now LIVE at @natrevbioeng! Read for free here: https://t.co/eedyTNCwPL Congrats to Irina Kopyeva (@UWBioE) and @RP_Brady (@UWChemE)! This was a fun one!
Light can be applied to engineer materials approaching the 4D complexity of tissues. In their Review, @coledeforest et al discuss the light-based fabrication of hydrogels - the union of light-based manufacturing and photoresponsive chemistries @RP_Brady
https://t.co/hLmGdmcobO
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Huge congrats to @kunlinwu whose @UWChemE Master's thesis work/manuscript in our lab received @RSCAdvances's "Outstanding Student Paper Award 2023" for the Materials Chemistry category! 🎉 Be sure to check out the paper, too:
pubs.rsc.org
The extracellular matrix (ECM) undergoes constant physiochemical change. User-programmable biomaterials afford exciting opportunities to study such dynamic processes in vitro. Herein, we introduce a...
We would like to highlight the winner of the @RSCAdvances Outstanding Student Paper Award 2023 in the Materials Chemistry category, Kun-Lin Wu from @UW, for his contribution in https://t.co/HjuDLctJ8M Read more about him here: https://t.co/2qcJvYzqje
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Join us this Wednesday, Sept. 25th at 3pm EST for a #TissueTalk with @UW Prof. @coledeforest on “User-programmable hydrogel biomaterials to probe and direct 4D stem cell fate.” See you there: https://t.co/cvdpWVcfPJ
Join us for #TissueTalks on Wednesday with guest speaker Cole DeForest from the University of Washington. Register here: https://t.co/snIGJjrK5G
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We're just ONE WEEK AWAY from the Society for Biomaterials (@SFBiomaterials)'s inaugural Northwest Symposia here in Seattle @UW on Sept. 19-20, 2024! Exciting speakers, posters, panel, social, & networking! Registration is still open! https://t.co/aXQasDosWT Come join the fun!
🙌Excited for the SFB Regional Symposia, September 19-20, 2024? We are! 👍Two full days of top-notch plenary talks, insightful sessions, interactive poster presentations, and fantastic networking opportunities! There's still time to register: https://t.co/bEQqe0Sfsz
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Want to photorelease proteins from biomaterials w/o exogenous light? Use BRET! "Bioluminescence Resonance Energy Transfer (BRET)-Mediated Protein Release from Self-Illuminating Photoresponsive Biomaterials" is live @J_A_C_S! 📜: https://t.co/ScUe0Vkn3E Congrats @teresarappphd!
Bioluminescence Resonance Energy Transfer (BRET)-Mediated Protein Release from Self-Illuminating Photoresponsive Biomaterials | JACS @coledeforest @UWBioE
@UWChemE @UWISCRM @UWMolES #Bioluminescene #BRET #Protein #Release #Biomaterials
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