Biophysical Journal
@BiophysJ
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Biophysical Journal, the premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research.
Rockville, MD
Joined August 2015
#OPENACCESS: Voltage gating and 4-aminopyridine inhibition in the Shaker Kv channel revealed by a closed-state model . Bernardo I. Pinto-Anwandter.
cell.com
The generation and propagation of action potentials in neurons relies on the coordinated activation of voltage-dependent sodium and potassium channels. The Kv1 (Shaker) family of potassium channels...
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Primary sequence not only codes for 3D structures but also for the distinct folding mechanisms, authors show in this simulation study.
cell.com
Protein sequences serve as a natural record of the evolutionary constraints that shape their functional structures. We show that it is possible to use only sequence information to go beyond predict...
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Special issue call for papers: Retinal Proteins: Experiment and Computation.
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Shu and Kaplan develop a multiscale whole-cell theory on mesenchymal cell migration under confinement, revealing that curvature slows down migration efficiency, even on stiff substrates.
cell.com
Mesenchymal cells navigate the extracellular matrix (ECM) in vivo by processing both its mechanical properties and confinement geometry. Here, we develop a multiscale whole-cell theory to investigate...
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#OPENACCESS: Outer hair cells: the rockstars of your inner ear! Kuni H. Iwasa et al. 2025 show how these tiny amps crank up cochlear volume in model systems. It’s like having a mosh pit in your cochlea-physics meets punk!
cell.com
Cochlear outer hair cells (OHCs) have two mechanosensitive elements: the hair bundle (HB) with mechanotrasducer channels and the piezoelectric lateral wall of the cell body. The present report...
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In the New and Notable "Micromanaging the nuclear lamina ," Alişya A. Anlaş highlights the paper "miR-548t-3p impairs nuclear mechanosensitivity and focal adhesion via lamin A/C downregulation ."
cell.com
From the shear stress of arterial blood flow to the cyclic strain of lung expansion and the gradual stiffening of tumors during cancer progression, epithelia encounter and respond to a wide array of...
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Ever wish you could cosplay as a bacterium? Massilia Abbas et al. 2025 made lipopolysaccharide nanoparticles that mimic bacterial surfaces - perfect for probing how microbes feel the world. Think of it as bacterial drag for biophysics!
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Special issue call for papers: Martin Karplus: In Memoriam.
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#OPENACCESS: A higher ATP concentration turns thick myosin filaments into an ON state, leading to altered cross-bridge kinetics. These X-ray data correlate low ATP levels to the inactivated myosin state observed in certain heart diseases.
cell.com
Cardiac contraction is achieved through cyclic cross-bridge interactions between overlapping myosin-containing thick filaments and actin-containing thin filaments. This process is powered by ATP...
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#OPENACCESS: In silico identification of substrate-binding sites in type-1A α-synuclein amyloids . Shraddha Parate, Fiamma Buratti, Leif A. Eriksson, and Pernilla Wittung-Stafshede.
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Past forces shape future firing: Xie et al present an electromechanical modelling framework to investigate the mechanical memory of excitable cells, revealing how past mechanical stimuli shape future responses via mechanosensitive channel inactivation.
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Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog:
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Check out the latest content from Biophysical Journal on our Online now page: gt;.
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Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang.
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#OPENACCESS: Macroscale optimal size of ICM vesicles regulated by quantum design principle in LH2 structure. Ying Zhang, Qianjin Chu, Luchao Du, Yugui Yao, Hailong Chen, Peng Wang, Jianping Zhang, Mingqing Chen, Lingfeng Peng, and Yuxiang Weng.
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Glycinergic synapses are like tiny post offices - but speed depends on how well the mailboxes (receptors) line up with the drop points (release sites)! Ronel Elbaz et al. (2025) reveal how this spatial setup shapes synaptic timing.
cell.com
Glycinergic synapses are the most abundant inhibitory synapses in the brainstem and spinal cord and are important for mediating rhythmic behaviors, such as locomotion and breathing. These synapses...
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Muscles = motors, but what if they had better timing? Jiaxiang Xu et al. (2025) show that delaying phosphate release is like shifting gears just right - boosting your MPG in the gym!
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Special issue call for papers: Martin Karplus: In Memoriam.
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#OPENACCESS: Effects of open-channel blocking peptides in NaV1.5 ΔKPQ . Maria Riedersberger, Madalina Woltereck, Paul J. Wagner, Kristin Focke, Sarina Höller, Angelika Lampert, Christian Alzheimer, Stefan Düsterhöft, and Tobias Huth.
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#OPENACCESS: DNA coronas resist nuclease degradation . Faisal Anees, Diego A. Montoya, David S. Pisetsky, Tariq Khan, Abhishek Kalpattu, and Christine K. Payne.
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