Xavier Trepat
@XavierTrepat
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Scientist of Living Matter, Professor @icreacommunity, Group Leader @ibecbarcelona, Jazz trombone @lalocojazz. The need to know.
Barcelona, Spain
Joined January 2015
New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). @IBECBarcelona
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A thread of our new preprint 🧵👇 🤩.
Have you ever thought about inflating tissues? .Or maybe quickly deflating those inflated tissues? . New #EpithelialMechanics pre-print: 🧵with pressure control, multiscale buckling, patterned wrinkling
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🚨 Second preprint of the week!. We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa🙌. Theory by Marino Arroyo and team.
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How to turn a layer of fibroblasts into a tulip 🌷?. Check out our new pre-print on shape-programmable living surfaces. Led by @pauguillamat @IBECBarcelona .
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RT @ahcells: There’s tons out there about fibroblast #mechanobiology in disease. In @ConfinementLab’s new review in @aplbioeng, Yeji gives….
pubs.aip.org
Fibroblasts play crucial roles in wound healing, cancer, and fibrosis. Many aspects of these roles are driven by the process known as fibroblast activation. The
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RT @SchwarzUlrich: (6/6) In summary, our new pipeline now allows us to dissect how such a complex multicellular system like a budding intes….
biorxiv.org
The intestinal epithelium in vertebrates has a characteristic architecture of protruding villi and receding crypts that enables nutrient absorption and cellular turnover. Intestinal organoids...
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RT @PeruccaAlice: 1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that rec….
nature.com
Nature Communications - Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a...
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Work conceived by Anna Labernadie during her postdoc in the lab—now running her group @CIPFciencia— collaboration with @CalonLab. Congrats to first authors Alice Perucca, Andrea Gomez and Oriol Mane.
ibecbarcelona.eu
The Micro Immune Response On chip (MIRO) allows tumours and their environment to be replicated in order to understand their response to immunotherapy-based treatments.
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RT @telomerase2: Explore emerging research with field leaders @KeystoneSymp - Organoids: Engineering Innovative Approaches for Basic and Tr….
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New preprint from the lab! We studied how single cells migrate up, down and about fibronectin gradients. Experiments by @icfortunato , theory by David Bruckner. Collaboration with @EdouardHannezo and @RaimonSunyer @IBECBarcelona .
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Sad to witness the implosion of #scitwitter, with all the great moments it brough us, but scientific exchange seems to be shifting for good.
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Very nice focus issue @CurrentBiology on Physics and Biology. Some of us wrote a perspective article on "Where physics and biology meet" led by @WallaceUcsf and Deborah Taylor.
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RT @MorphoLab_AS_AR: 1/4 In our new concept paper in @BiolTheory, we elaborate an investigative approach that prioritizes the art of carefu….
link.springer.com
Biological Theory - The roles played by physics in the study of the life sciences have taken many forms over the past 100Â years. Here we analyze how physics can be brought to bear on the...
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RT @pwoakes: We wrote a fun review all about the different types of mechanosensing and the ways cells regulate these important processes. C….
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RT @BenFabryErl: Thrilled to share that our paper on 3D traction force measurements of migrating immune cells (and growing axon growth cone….
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RT @JgrosL: Finally, out in @Nature!.A great team effort to address very constructive reviews. With @caldarellip1, Alexander Chamolly, @vil….
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RT @SchwarzUlrich: 📢Paper alert📢. Great @Cluster3DMM2O collaboration with the group of @EvaBlascoPo on stimuli-responsive mechanical metama….
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RT @EpiMechFC: Hi, I’m David Brückner @d_brueckner. I’ll take you through how cells in a tissue can use information distributed by biochemi….
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RT @NatalieADye: Our latest is out!! 🙌Active shape programming drives Drosophila wing disc eversion | Science Advances .
science.org
In-plane cellular dynamics drive 3D tissue morphogenesis of the everting Drosophila wing disc epithelium.
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