Arthur Mortha
@nkg2d1
Followers
3K
Following
11K
Media
734
Statuses
3K
Professor at the University of Toronto Canadian Research Chair in Mucosal Immunology #theonlylabever #punkrockthursday #FCKNZS @preprintclub @theonlylabever
Toronto, Ontario
Joined April 2013
Here, the marvelous Pailin, Ling Ling and Louis discuss underappreciated functions of gut macrophages, reaching far beyond their well-known roles in immunity. We hope you will find it interesting. YKW? Read it anyway! It's free. #proudPI #openaccess
https://t.co/jETTLkTHHB
5
32
117
This IS happening! June 2-4, 2026 the 6th International Conference on Innate Lymphoid Cells in beautiful Vancouver, BC 🇨🇦 News via: https://t.co/pbuzutCkgq Please, tell all your friends and share widely. 😘 #2026ILC6 #ILC6 #ILC6Vancouver
2
7
16
Building prevention in ibd 👍 Identifying Potential Targets for the Interception of Inflammatory Bowel Disease: Toward Precision Prevention
academic.oup.com
Abstract. There is growing recognition that inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is preceded by a
1
7
30
Our new study led by Bishan Bhattarai shows that circadian proteins REV-ERBα/β protect gut health by maintaining ILC3 homeostasis. Without them, ILC3s turn into IFNγ+ ILC1s, fueling inflammation. Chick it out! https://t.co/f3HaHEODzz
nature.com
Nature Immunology - Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt.
0
23
88
Hot off the press in@ImmunityCP! 🔥 Proud to share our new perspective — a collaborative effort with fantastic colleagues — proposing a unified framework to classify neutrophil subpopulations. #ThePowerOfMany 👉 https://t.co/cSK5cHssDM
6
42
144
Why Dr. Arthur Mortha's lab called @TheOnlyLabEver? Find out in our latest episode, and learn about his work on ILCs and their interactions with the #microbiome! Listen now: https://t.co/h0lYtJp68T
0
2
6
🎉 Excited to organize the 2025 Toronto IBD Research Symposium happening May 23 @SinaiHealth Bridgepoint Auditorium! 🔬 Cutting-edge IBD research:🧪 Multi-omics | 🧬 Preclinical CD | 🥗 Diet | 🩺 Surgery | 🔬 Pathology | 🖼️ Radiology @ptandonGI @amandaricciuto @UofTGastroHep
3
7
33
Open-access @Nature paper from the @IBD_GIVES21 consortium, co-led by @Siew_C_Ng and I, funded by @HelmsleyTrust, and supported by @IOIBD1, reveals the global evolution of IBD across epidemiologic stages. Co–first authors: @dataLindsay & @LingWWindsor
nature.com
Nature - An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across...
6
41
110
Very excited to share our latest work -demonstrating 50% diagnostic rate for CODE and 3 new CODE genes, MYO1A, GRWD1, and MON1A. @NEJM The Genetic Architecture of Congenital Diarrhea and Enteropathy | New England Journal of Medicine
nejm.org
Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated wit...
1
17
48
.@darwinsbro, @QFKC et al. @ArdolinoLab show that PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway. https://t.co/HrqjfbSjeJ 📘 In Tumor #Metabolism 2025: https://t.co/xND9s10p4g
#KSTumorMetab25
0
14
42
In our #DoubleFeatureEvent, Toronto’s Robbie Jin will present a #preprint from @BioYupi @diwakardavar @AClementinaM @airdlab about the way DKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance. 🥩🦪🥜 https://t.co/T0w4Xz425H
biorxiv.org
Approximately 50% of cancers exhibit decreased CDKN2A expression ( CDKN2A Low), which is linked to immune checkpoint blockade (ICB) resistance. While CDKN2A is traditionally recognized as a tumor...
2
1
7
Tomorrow in #PreprintClubHub1 Toronto’s Jennifer Ahn will present a #preprint from @AnnaMolofskyLab @Molofsky_lab @JeanneTPaz about how type 1 lymphocytes and #IFN accumulate in the thalamus and restrict seizure susceptibility after traumatic brain injury https://t.co/kUcFQb8nvX
biorxiv.org
Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide and can lead to secondary sequelae such as increased seizure susceptibility. Emerging work suggests that the...
0
3
6
Cao, Burrows, @nkg2d1 @theonlylabever show that the protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA. https://t.co/hQXdU2f3Ga 📘 Host–Microbe Interactions 👉 https://t.co/9ynwjJZqHX
#KSHumanMicro25 #KSHostMicrobe25
0
1
12
In our Wednesday #DoubleFeatureEvent, Oxford University’s own Lisha Jeena will share a #preprint on the way type I #IFN, induced upon respiratory viral infection, impair lung metastatic initiation. 🫧🦠🫁 https://t.co/qRDL1aAp5X
biorxiv.org
Invasive breast cancer accounts for 7% of all cancer-related deaths, with the lungs being a common site of metastases. At the same time, lower respiratory tract infections are a common cause of...
0
1
6
On Wednesday, January 29th, in #PreprintClubHub1 Mount Sinai’s Annie Khamhoung will present a #preprint about how astrocyte-derived MFG-E8 facilitates microglial synapse elimination in #Alzheimers disease mouse models. 🧠-🐭-💃 https://t.co/GM1kb0Mowg
biorxiv.org
Region-specific synapse loss is an early pathological hallmark in Alzheimer’s disease (AD). Emerging data in mice and humans highlight microglia, the brain-resident macrophages, as cellular mediators...
0
1
4
A gut protozoan plays a key role in shaping the immunological steady state of the lung @CellCellPress Preview by @BenJMarsland
https://t.co/6MYMvUWSRk Manuscript from @nkg2d1
https://t.co/Cz83xIE6Dw
2
9
41
🫁 From the gut to the lung: @DrKyleBurrows and a team in Dr. Arthur Mortha's (@nkg2d1) lab at @UofT investigated how gut microbiota affects extra-intestinal diseases in the lung. @CellCellPress paper - https://t.co/b2LWhJRlnY Episode - https://t.co/1CLa2YB33q
0
8
22
Tomorrow, in #PreprintClubHub1, Oxford's own Ester Gea-Mallorquí @estergeama will share a #preprint about the role of T cell-derived IFN-γ in suppressing T follicular helper cell differentiation and antibody responses during viral infections. 🤒💨⚔️ https://t.co/wpeGY3HyVU
0
2
4
In vivo enhancement of tumour-specific T cells via peptide–MHC-pseudotyped retroviral gene delivery
nature.com
Nature Reviews Immunology - A preprint by Xu et al. shows that MHC-pseudotyped retroviruses can reprogramme, activate and expand tumour-specific T cell populations in vivo.
0
4
18
Here it is, la pièce de résistance
Now online! A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity
0
1
5
Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses https://t.co/JpNnM6XWly
@CellReports @sarah_crome
1
16
61