Check out Research Briefing for our recent paper in Nature Immunology @DuSiling.

RT @DuSiling: 🧵1/.Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF….

Our new study by @DuSiling reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling.

Congrats to @KedmiRanit’s group! RORγt⁺ APCs prime food-specific pTregs and induce oral tolerance. Infection or food poisoning temporarily bypasses this, allowing CD8αβ T cell responses to mimicked food antigens without breaking long-term oral tolerance.

Find the referenced papers below:.Brown: Mucida: Littman: Gardner: Schraml: Colonna:

As RORγt⁺ APC gain attention for their tolerogenic roles, Schraml’s group also highlights their inflammatory potential. Key questions remain: How are RORγt⁺ APC specified? Are eTAC and RORγt⁺ DC distinct or the same? What dictates tolerance vs. inflammation? Fast-moving field!.

Big shoutout to Brown’s group: IRF8-dependent TC are essential for inducing food-specific pTregs & establishing oral tolerance! In line with recent work from Mucida’s, Littman’s, Gardner’s, and our group highlighting the role of RORγt⁺ APC in this process.

RT @WashU: Congratulations to physicist Carl Bender of @washuartsci and immunologist Marco Colonna @washumedicine, who have been elected to….

Excited to share that our work by @PatFernRod and @TongWu99 is published in Cell: RORγt+ DCs are required to induce oral tolerance. Their absence reduces pTregs and impairs oral tolerance to dietary antigens. Read more:

RT @ShoutangW: Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control ….

RT @JExpMed: Cai et al. @TheColonnaLab @washumedicine show that, in an #Alzheimers mouse model, microglial Atg7 deletion impairs plaque cov….

RT @zefachi: Excited to share that our work is featured on the cover of the latest issue of Cell Host & Microbe! Check it out! @TheColonnaL….

Our new paper in Cell Host & Microbe:.Low-fiber diets worsen C. difficile infection by increasing epithelial MHC-II and expanding pathogenic CD4+ IELs. Fiber-derived acetate and FFAR2 boost ILC3 IL-22, suppressing colonic MHC-II and aiding recovery.

Our work by Fachi et al. @zefachi is out in PNAS! We show how NKp46+ ILC3s boost early gut defense against C. difficile infection by producing GM-CSF to support neutrophils. A potential path to new CDI treatments!.

Farewell party for David, a student from Ulrike Schleicher lab, who was a visiting student in our lab! Good luck David

RT @DuSiling: 🧵 Excited to share my first preprint from my PhD @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages….

Check out our newest resource led by @jaeger_natalia and @UlezkoAlina describing the NK-ILC1 gradient in human tissues: The IEL contains true mature (PRDM1+) and immature (PRDM1-) EOMES-ILC1, while other tissues harbor ILC1-like NKs expressing ZNF683.

RT @TheXavierLab: Collaboration with @TheColonnaLab & others, in press at @Dev_Cell: The FGFR1OP gene, implicated in #Crohns, contributes t….

Our new paper led by @TihanaTrsan, collaboration with @TheXavierLab, investigating the link between FGFR1OP and Crohn’s disease. Deletion of FGFR1OP, a centrosomal protein, in mouse gut cells disrupts crypt architecture, causing inflammation and fatality

Congrats @PatFernRod! Distinct lineages contribute to cDC2 diversity: lymphoid-derived pDC-like and myeloid-derived pre-cDC2 both develop into transcriptionally similar cDC2, crucial for humoral immune responses, and are distinct from pro-DC3 derived DC3.