Ari Molofsky
@Molofsky_lab
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Immunologist, Clinical Pathologist. Our research lab studies immune niches in tissue health and disease.
San Francisco, CA
Joined June 2016
Fibroblasts help the body heal, & a discovery about the cells could lead to new therapies for brain injury. “The goal is to give someone who’s experienced a traumatic brain injury or stroke the best outcome possible,” Dr. Ari Molofsky (@Molofsky_lab) says.
ucsf.edu
UCSF scientists discovered that an overlooked cell type in the brain plays a central role in healing traumatic brain injury. Understanding how it does this will lead to treatments for injuries that...
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For the broader audience, a nice summary (and some beautiful videos) on our recent publication. These Cells Have Hidden Powers That Could Heal Brain Injuries
ucsf.edu
UCSF scientists discovered that an overlooked cell type in the brain plays a central role in healing traumatic brain injury. Understanding how it does this will lead to treatments for injuries that...
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This IS happening! June 2-4, 2026 the 6th International Conference on Innate Lymphoid Cells in beautiful Vancouver, BC 🇨🇦 News via: https://t.co/pbuzutCkgq Please, tell all your friends and share widely. 😘 #2026ILC6 #ILC6 #ILC6Vancouver
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...Finally, please check the link from @nathanec1 to a complete Tweetorial on the story.
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...many more thanks are in order, including the research labs of Dean Sheppard, Jeanne Paz, Richard Daneman, Fernando Gonzalez, Mani Aghi, and James Bourne. Collaborative and interdisciplinary science is the best!
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Excited to share our research, spearheaded by MSTP trainee @nathanec1, with contributions from ~9 research labs, focused on the changing roles of brain fibroblasts (and immune cells) in brain injury. Thx in particular to @AnnaMolofskyLab, Tom Arnold lab. https://t.co/j2gWnMvmfX
nature.com
Nature - Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate...
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1/ Thrilled to share that my PhD thesis work is now out in its final form @Nature! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @Molofsky_lab. https://t.co/rqrvY2QBWJ
nature.com
Nature - Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate...
1/ Excited to share my thesis work, now out as a pre-print: “Dynamic fibroblast-immune interactions shape wound healing after brain injury”
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Review @SciImmunology @Molofsky_lab @AnnaMolofskyLab @nick_mroz @PhagocyticPai The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues https://t.co/kIN1n6RiUK
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And a shout out to Pailin Chiaranunt, who worked with Nick Mroz to co-author! Pleasure as always to collaborate with the AV Molofsky team as the links between neuroscience and immunology - the two great 'organismal organizers' - only to continue to expand.
In a new Review, scientists discuss how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance. @nick_mroz @AnnaMolofskyLab @Molofsky_lab Learn more in Science #Immunology: https://t.co/ipRvbnbg3d
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This week in @ScienceMagazine: @jerika_barron, @Molofsky_lab, @AnnaMolofskyLab, & colleagues report that #ILC2 promote #postnatal #synapse formation in the #brains of #mice. An absence of ILC2 leads to impaired #social #behavior in adult mice! https://t.co/3tpL17b0IC
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https://t.co/SWLOkttzG9 thanks as well to @jfosterlab for this great highlight of the paper
science.org
Meningeal innate lymphoid cells guide inhibitory neurons in early life
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ILC2s in the brains.....young brains!!!! Maybe it's too late for my Halloween humor. What a privilege to work with the amazing @annamolofskylab with Jerika, Nick, and the team!
Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science https://t.co/u2fQ2j2OeN
@jerika_barron @ Nick Mroz
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Check out Jin Young's insightful review on the similarities between pathologic senescent fibroblast populations identified in cancer and fibrosis. @UCSFAging Convergent evolution of senescent fibroblasts in fibrosis and cancer w...
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"I don't think our Founding Fathers EVER envisioned a six-four, bald, tattooed, half-Black, half-Samoan, tequila drinking, pickup truck driving, fanny pack wearing guy joining their club – but if it ever happens it'd be my honor to serve you, the people."
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Can you smell what the Rock is cooking? I can. @TheRock for President!
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Excited to see this lung fibroblast tour de force come out. Huge congrats to Tatsuya, Dean, and colleagues….amazing new genetic tools too!
Fibroblasts are everywhere in our tissue as structural cells, yet we are only beginning to understand them. Today in @Nature, we report that lung-specialized alveolar fibroblasts orchestrate lung homeostasis, inflammation, and fibrosis. 🧵👇(1/n) https://t.co/DFycGLzlNV
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🙌 Thank you, NOMIS Foundation, for your generous $20M gift to support our new Neuroimmunology Initiative at Salk! 🧠🔬 “We are excited to take a deep dive into the understudied intersection of neuroscience and immunology,” says Professor Susan Kaech. Read more about this
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If you're interested in anti-tumor immunity and metabolism... Arg:Orn ⚖️ TAM/CD8 Article: https://t.co/QMJa7D4KbT News and Views:
nature.com
Nature Cancer - Tumor fibrosis is known to suppress anti-tumor immunity. A new study now highlights the role of tumor-associated macrophages in coordinating fibrosis-mediated metabolic changes in...
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My first visit to Sweden (and Lund)…psyched to meet folks and talk science and life!
Don't miss out on our upcoming #LundImmunotalks! We have two amazing speakers on my favorite topics: B cells and fibroblasts!
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Congrats to Wendell Lim and the amazing team...and excited for answers soon! UCSF Scientists Build a Molecular ‘GPS’ to Guide Cell Therapies
ucsf.edu
UCSF scientists have been awarded more than $30 million to develop “tissue GPS,” a new system using engineered T cells to guide therapies directly to their targets in the brain to treat neurological...
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