Dr Francesca Telese
@TeleseFrancesca
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Studying the complexity of the brain to cure diseases. Academic mom of 2. First Gen. Lover of the outdoor life and espresso. https://t.co/7GxPWqP2Pc
San Diego
Joined May 2011
NIH will no longer require letters of intent or prior approval for applications requesting over $500,000 in direct costs
Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Intent and Unsolicited Applications Requesting $500,000 or More in Direct Costs
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A functional perspective on astrocyte heterogeneity. A review by @bcm_neurosci @bcmhouston Benjamin Deneen & colleagues in @TrendsNeuro #SfN2025
cell.com
Astrocytes are glial cells of the central nervous system (CNS) that perform an array of diverse functions that are essential for brain activity. Studies on the functional diversity of astrocytes...
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New online! Genomics of drug target prioritization for complex diseases https://t.co/C2BZTB0vsD
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CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci https://t.co/5VtEnCmKEB
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More powerful tools for understanding the brain. 🧠🔍 Today, comprehensive, cross-species developing brain cell atlases were released to help advance health and disease research. 🧵 #studyBRAIN #BICAN @USBrainAlliance
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Atacformer: A transformer-based foundation model for analysis and interpretation of ATAC-seq data https://t.co/us4PaLgt2a
#biorxiv_bioinfo
biorxiv.org
Introduction Chromatin accessibility profiling is an important tool for understanding gene regulation and cellular function. While public repositories house nearly 10,000 scATAC-seq experiments,...
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Hot off the press @NeuroCellPress "From variants to mechanisms: Neurogenomics in the post-GWAS era" Genetic architect -> biological mech for ASD/SCZ/AD Major effort led by MSTP student Michael Margolis + great collab w/ @MichaelZiller5 & @WrayNaomi
https://t.co/Iskl55oEAK
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New online! Decoding the regulatory genome with large-scale deep learning
nature.com
Nature Reviews Genetics - In this Journal Club, Peter Koo reflects on the 2021 publication of Enformer and its impact on the use of deep learning for modelling the regulatory genome.
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In our latest Registered Report, @PengyiYang82 and colleagues compare computational methods for single-cell multimodal omics data integration and provide recommendations for different tasks and scenarios. https://t.co/xAJOASTv6y
nature.com
Nature Methods - This Registered Report compares computational methods for single-cell multimodal omics integration and provides recommendations for different tasks and scenarios.
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Our October issue is live! 🥳 https://t.co/RcmU6aV61O On the cover, single-cell DNA-RNA sequencing (SDR-seq) links genetic variants to gene expression. Artwork by Tobias Wuestefeld. Paper here: https://t.co/Jj6TpEtxlK
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Please RT: We are recruiting a postdoc in statistical genetics for a project in my lab on genes and environment in autism
We are proud to be one of the 13 projects funded by the NIH Autism Data Science Initiative. Our project: "Elucidating the Interplay of Genes and Environment in Autism Using Genomic and Exposure Data from Large Populations" 🧵 https://t.co/7gp6gBNYgn
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For decades, human genome editing has been limited to small, localized modifications. Today, in a new paper published in @ScienceMagazine, researchers from the @pdhsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.
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LRP8 is a receptor for tick-borne encephalitis virus | Nature
nature.com
Nature - LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, is a receptor for tick-borne encephalitis virus.
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Since legalization new schizophrenia cases linked to heavy cannabis use have nearly tripled.
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🚨High-Potency Cannabis Pub🚨 @UCLACannabis & @RANDCorporation #SystematicReview with @s_l_lake, @BeauKilmer, @conormurray points to ⬆️ "problem" cannabis use. 🧠Mental health? Poor outcomes for psychosis. More research needed! W/@CAcannabisdept support https://t.co/2DPTIrzSKN
psychiatryonline.org
Objective:Amid continuously rising concentrations of delta-9-tetrahydrocannabinol (THC) in cannabis (i.e., potency), high-potency cannabis is a major topic in contemporary cannabis policy discussio...
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New NIH Article: Scientists design gene delivery systems for cells in the brain and spinal cord https://t.co/6qbffR9TB8
#studyBRAIN
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New preprint alert: https://t.co/RugxCYzlSH. Excited to share our analysis on the impact of genetic variants on single-cell chromatin accessibility in blood, using scATAC-seq and WGS from over 1,000 donors and 3.5M nuclei as part of TenK10K phase 1 🧬 🧵👇 (1/n)
medrxiv.org
Understanding how genetic variation influences gene regulation at the single-cell level is crucial for elucidating the mechanisms underlying complex diseases. However, limited large-scale single-cell...
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Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics. #SingleCellTotalRNA #scRNAseq #scNoncodingRNA @biorxiv_genomic
https://t.co/Tp8kiAnKDA
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My colleagues at the @nytimes and I have been investigating the cannabis industry and health risks associated with marijuana for more than a year. Our latest story is about how cannabis poisonings have sharply increased in recent years, especially among kids. Read the thread -->
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Cocaine use disorder is associated with lower brain state transition energy particularly in higher order and excitatory networks https://t.co/ZjabOQ0jMt
#biorxiv_neursci
biorxiv.org
Cocaine use disorder (CUD) detrimentally impacts personal health, social relationships, and economic opportunity. Here, we assess CUD-associated shifts in brain dynamics using Network Control Theory...
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