Michael Gandal
@mikejg84
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Hetznecker Associate Professor, Psychiatry & Genetics at Penn/CHOP. Developmental brain genomics & dad jokes
Philadelphia, PA
Joined October 2011
New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment. Major developmental shifts in #genetic reg., New colocalized risk genes at ~60% of #psych #GWAS loci. #PsychENCODE24
https://t.co/COilXdAAAh
science.org
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain....
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Great review paper on neurogenomics, especially neuropsychiatric genetics. As I’ve said before, much of the near future of neurogenomics is less about identifying risk loci for neurological disorders (both degenerative and psychiatric) and more about functional interpretation
Hot off the press @NeuroCellPress "From variants to mechanisms: Neurogenomics in the post-GWAS era" Genetic architect -> biological mech for ASD/SCZ/AD Major effort led by MSTP student Michael Margolis + great collab w/ @MichaelZiller5 & @WrayNaomi
https://t.co/Iskl55oEAK
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Hot off the press @NeuroCellPress "From variants to mechanisms: Neurogenomics in the post-GWAS era" Genetic architect -> biological mech for ASD/SCZ/AD Major effort led by MSTP student Michael Margolis + great collab w/ @MichaelZiller5 & @WrayNaomi
https://t.co/Iskl55oEAK
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"Long Read Genome Sequencing Elucidates Diverse Functional Consequences of Structural and Repeat Variation in Autism"
medrxiv.org
Long-read whole genome sequencing (LR-WGS) technologies enhance the discovery of structural variants (SVs) and tandem repeats (TRs). Application of LR-WGS has potential to identify novel risk factors...
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Our recent commentary on two very interesting preprints using long-read whole genome sequencing to uncover novel variants in ASD from @sebatlab and evan eichler labs. https://t.co/0qHhCCymy1
thetransmitter.org
Strips that are thousands of base pairs in length offer better resolution of structural variants and tandem repeats, according to two independent preprints.
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Excited to present our recent work as part of the @StanleyCenter Symposium "Severe Mental Illness: From Genes to Mechanisms to Therapeutics" at the @broadinstitute. A fantastic lineup spanning basic science, genetics, genomes, to human clinical trials! https://t.co/uMrFA1rQ3b
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Important new meta-analysis shows no link between in-utero MPH, AMPH, or atomoxetine exposure and any NDD outcome. Great news for women hoping to keep taking their stimulants during pregnancy (though still slightly higher risk of gest HTN, abruption, etc) https://t.co/ldWrOMgE9Y
nature.com
Molecular Psychiatry - In utero exposure to methylphenidate, amphetamines and atomoxetine and offspring neurodevelopmental disorders – a population-based cohort study and meta-analysis
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Phenotypic analysis of 11,125 trio exomes in neurodevelopmental disorders https://t.co/vJEO0DTdeW
#biorxiv_genetic
biorxiv.org
Genomic sequencing is widely used to identify causative genetic changes in neurodevelopmental disorders, such as autism, intellectual disability, and epilepsy. Most neurodevelopmental disorders also...
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Fascinating study comparing >200k veterans started on GLP-1R agonists for diabetes vs 1.2M started on other T2D meds, tracking 175 outcomes over 3.7 yr. 10-20% reduction in neuropsych outcomes, including schizophrenia, SUD https://t.co/Qkty16GMIc
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Awesome tools for complex trait genetics, a collection curated by Michel Nivard: https://t.co/bBQjlfoBu6 🧬
github.com
A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics
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The @Penn @ChildrensPhila Lifespan Brain Institute held its 2024 symposium, "Pathways to Psychosis," Nov. 4, featuring a line-up of lectures on risk mechanisms in #schizophrenia, #brainimaging in early psychosis, lived experiences, & more. Learn more: https://t.co/re6pYU3UpO
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Decoding sequence determinants of gene expression in diverse cellular and disease states | bioRxiv
biorxiv.org
Sequence-to-function models that predict gene expression from genomic DNA sequence have proven valuable for many biological tasks, including understanding cis -regulatory syntax and interpreting...
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Excited to share that denovo-db is now available on @ZENODO_ORG ( https://t.co/a6RAlR47Ov)! The new version of denovo-db contains >1 million de novo variants from published data on >70,000 individuals. After much thought, this feels like the right step for sharing with the
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Online Now: Large-scale map of RNA-binding protein interactomes across the mRNA life cycle https://t.co/5o6Ml1xQbr
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Excited to see the revised version of our paper now published at @CellGenomics led by @YSereb
https://t.co/rqJGg0zsT3
cell.com
Serebrenik et al. develop a method for pooled induction of ectopic protein-protein interactions by combining gene tagging using a ligand-binding domain with generic heterobifunctional small molecul...
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New research from @ChildrensPhila’s Gandal Lab + the Lifespan Brain Institute shed light on the genetic underpinnings of complex neurodevelopmental & psychiatric disorders as part of the @NIMHgov's #PsychENCODE initiative. Learn more: https://t.co/Csta5dHvKZ
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What if Facebook actually followed the (sensible) advice of its own Llama3 AI platform on how to mitigate social media's exacerbation of our current mental health crisis:
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New review from @coletrapnell summarizing major statistical inference methods applied to single-cell, spatial, perturbation data to study gene function in healthy and disease states @NatureRevGenet
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