RT @pdhsu: Come join the bridge editing team @arcinstitute and build the future of genome design!.

RT @GENbio: STING Inhibition Differences Revealed Between Humans and Mice. Mechanistic discrepancies between species highlight the limitati….

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This interface defines a previously unrecognized, drug-accessible site on human STING and offers a promising direction for designing inhibitors that are effective across contexts. This sets the stage for future therapeutic development in autoimmunity and inflammation.

To move beyond the limitations of context-dependent modifications, Li's team focused on the oligomerization interface itself. This led to the discovery of a minimal 8–amino acid peptide that binds a defined, surface-exposed pocket and blocks STING activation.

Palmitoylation at C64 and C91 regulates disulfide bonding at C148, which stabilizes STING oligomers. This disulfide formation is necessary, but if it occurs too early, it locks STING into an inactive state.

Instead, Li's team finds that C64, a conserved and basally palmitoylated cysteine, is essential for human STING activation. C64 prevents premature assembly of STING into non-productive oligomers and serves as a key checkpoint before activation.

Li and her colleagues show that C91 palmitoylation, the target of several inhibitor compounds including H-151, is dispensable for human STING signaling. This helps explain why some inhibitors block STING in mouse cells but not in human immune cells.

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Core Investigator @li_lingyin's new paper in @NatChemBio investigates why human STING inhibitors have shown limited efficacy, despite strong activity in mouse models. The study, led by @xujun_cao and @rjchan426, finds that the commonly targeted site on STING is not required for

In this Q&A with @NikoMcCarty, Jain discusses her group's latest discoveries, the revival of mechanistic research into vitamins, and how Arc enables her metabolite-centric approach:

Welcome @ishahjain, Arc's eighth Core Investigator! Jain has spent more than a decade studying how the human body senses, and responds to, external molecules—especially oxygen and vitamins.

RT @EricTopol: Getting to the virtual cell is the holy grail of life science. Now there's a challenge on to accelerate it..

Love the enthusiasm @nalidoust! Virtual Cell Challenge entrants who are happy to share their models will benefit the entire field.

RT @yusufroohani: How close are we to simulating living cells?. Today @arcinstitute is launching the Virtual Cell Challenge (VCC), an annua….

RT @anthonycosta: Incredibly excited to support and partner with @arcinstitute to accelerate our understanding of biology -- remember, if y….

RT @UltimaGenomics: Proud to support @arcinstitute's inaugural #VirtualCellChallenge with @10xGenomics and @nvidia, to push the frontiers o….

RT @genophoria: We are excited to bring to you the Virtual Cell Challenge, a new benchmark initiative from the @arcinstitute to evaluate pr….

RT @xiaofei_lin: .@arcinstitute has announced the inaugural “Virtual Cell Challenge,” sponsored by @nvidia,.@10xGenomics, and @UltimaGenomi….