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@PlantEvolution
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Weigel Lab aka WeigelWorld Retweet≠endorsement @MPI_Bio #OpenScience COIs GoogleScholar
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I’m proud to be German 🇩🇪 by birth, American 🇺🇸 by choice, and European 🇪🇺 at heart.
We set up a false dichotomy if we say scientists are "citizens of nowhere"; I am proud Brit, a committed European, and a member of the human species - all of these labels, cultures and political systems (however imperfect!) matter to me!
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Alarming: Proportion of research papers submitted where the first author is female, by month over past five years. (Data from 60k journals, so this is more than highly significant.)
@timeshighered
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[1/10] Perhaps most provocative study ever from my lab. Transgenerational
#epigenetics
pales in comparison.
@GreyMonroe
reexamined spontaneous
#mutation
data in
#Arabidopsis
. This led him to ask this heretic question: Could mutation rate bias be adaptive?
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This came up recently: "What's your advice for scientific writing?" Here is my advice:
Read Hemingway. Then write like Hemingway. Short sentences. Simple words.
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#auxin
—one molecule to rule them all. If you thought this only applies to 🌱🌾🌳🌿, check out this paper on the gut
#microbiota
& pancreatic
#cancer
!
(Amazingly, the term “auxin” is completely missing from this paper, even though that is what 3-IAA is).
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If you are an African scientist and have difficulty leaving the Ukraine because of visa issues, please DM me whether we can assist by offering a position at our institute.
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A single wheat field produces seeds with enough new mutations that in average every place in the wheat genome is mutated.
#evolutionisreal
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100%
@maxplanckpress
: An amazing 1st yr PhD walks in, proposes gigantic expt that is somewhat peripheral to your own research, but requires significant resources incl hiring a tech in another country. Long-term unrestricted funding allows you to say: YES. Five years later: This.
Check our latest paper in Nature: "Natural selection on the Arabidopsis thaliana genome in present and future climates"
w/
@HernanABurbano
@OBossdorf
@Ras_Nielsen
@PlantEvolution
, and many colleagues that helped in the field.
👇
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What excites me most about receiving this award:
First, that it is named for one of my genetics heroes, Barbara McClintock. Second that the work of all the previous awardees is full of examples where plant genetics has yielded insights that go far beyond plants.
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Plants are the coolest!!!
Mechanical stimulation of leaf 🍀 hairs by rain 🌧 💧triggers calcium waves, leading to immune response
🌿🍀🌱🌾
@M_Matsumura1993
@NomotoMika
@SpoelLab
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Wonderful to see this recognition for Emmanuelle Charpentier & Jennifer Doudna. Now let’s hope that European politicians finally recognize the power of
#CRISPR
for improving human health and well-being directly, and also indirectly through
#genomeediting
of crops.
BREAKING NEWS:
The 2020
#NobelPrize
in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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Important genomic regions mutate less often than do other regions!
Excellent summary by Jianzhi Zhang of our work led by
@Grey_Monroe
@ThSrikant
with help from several great collaborators
Short 🧵 1/n
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To the enthusiastic reviewer of our manuscript: Thanks!
To the less supportive one, but with constructive criticism: Thanks!
To the dismissive author of a 2-liner recommending rejection b/c all evolution is "soft": Get a life & I hope you treat your students better
@AcademicsSay
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What a cool paper! The parasitic plant dodder doesn't make FT (aka florigen), and instead relies on the mobile FT protein from its host to initiate flowering. (Of course especially pleased since we discovered FT and its partner FD in 1999 & 2005).
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Biology never ceases to amaze: learned today from
@KostChristian
about metabolic cross-feeding via intercellular nanotubes among bacteria to reduce the chances of freeloading cheaters to benefit from the exchanges metabolites
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Don’t mind the math — this is a very well written and accessible paper; I learned more about human
#GWAS
from reading this than all of the original GWAS papers.
A population genetic interpretation of GWAS findings for human quantitative traits
#pleiotropy
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No genome required: Finding causal genetic variants in plants without complete genomes
#GWAS
#kmers
@voichek
@biorxivpreprint
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Big 🙏🏻🙏🏻🙏🏻 to all former & current members of Weigel Lab aka WeigelWorld! Can’t believe it has been 30 years!
I’ve been incredibly lucky to have been so often at the right place & right time, with someone lifting me up at every stage of my career. That’s why I pay it forward.
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@Europarl_EN
Please listen to the young scientists of the world:
The science is clear – yes to
#CRISPR
and other New Genetic Technologies!
#NGT
#NGTs
.
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It’s wrong to shame colleagues & coworkers for working too much, as it’s wrong to shame others for working too little. It’s both a personal choice & a matter of mental capacity.
Also, not all hours are the same — demands of rote work different from creative work.
If you’re an academic habitually working much more than 40 hours/week, you’re probably producing less good work than if you reduced your hours. If you absolutely CAN’T manage within a reasonable schedule, you’re probably doing a lot of things that don’t advance your field/career.
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MEPs - please listen to scientists & vote YES on
#NGTs
! 💚
@katarinabarley
@delarabur
@woelken
@berndlange
@Andi_Glueck
@BirgitSippelMEP
@EnginEroglu_FW
@egebhardtMdEP
@gabischoff
@jcoetjen
@EuropaJens
@Schuster_MdEP
@MariaNoichl
@BuschmannMartin
@Europarl_EN
@weplanetint
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Congratulations,
#plant
scientists Gloria Coruzzi, Maria Harrison, Stephen
@LongLab
, Pamela
@pcronald
, Dan Voytas,
@JaneLangdale
to their election to the
@theNASciences
!
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Just arrived in Glasgow. Customs officer asked me where we publish. I told him where our last two papers were accepted. His answer: “Now you’re showing off!” 😂🤣 Scots are very sophisticated.
#ICMPMI2019
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For the International Day of Women and Girls in Science, I salute four impressive friends and colleagues because they combine first-rate science with exceptional leadership and being decent fellow humans:
Joanne Chory
Caroline Dean
Ottoline Leyser
Gloria Coruzzi
#WomenInSTEM
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Ausgewogene Berichterstattung? Die Meinung eines ausgewiesenen Spitzenwissenschaftlers zu
#GenomeEditing
in grün, die ungleich weniger qualifizierte Gegenmeinung in rot.
@katharina_mau
@AU_de
: Würden Sie Leugnern der Klimakatastrophe ebenfalls mehr Platz geben?
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So happy about this award! Very proud of our contribution to genetic tech (activation tagging, amiRNAs, mapping-by-sequencing and so on), but biotechnology work with Ove Nilsson, accelerating tree flowering from years to months, remains highlight of the lab’s achievements!
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Hope to see many plant biologists tonight when I debate Renate Künast, former Federal Minister of Agriculture and prominent member of the Green Party, on the merits of
#GMO
and
#GenomeEditing
in crop plants. Heidelberg
@DAIHDGermany
8 pm.
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[Please repost] Looking for a PhD program that goes from molecules to ecosystems? Look no further, and apply to us! I'm offering two projects, on the 1001 Genomes Plus project and on investigating functional diversity in the plant immune system
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Frustrated because reviewers dislike thought-provoking speculations in your papers, making writing a Discussion so much less fun?
@eLife
now has a "safe space for speculations"!
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[1/7] Absolutely chuffed about
@joybergelson
’s, Fabrice Roux’ and my lab’s
#PATHOCOM
project selected for funding by
#ERCSyG
@ERC_Research
program. Our full project proposal at , and briefly explained in this thread.
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Amazing resource! Transgenic lines expressing 1255
#Arabidopsis
transcription factors fused to glucocorticoid receptor (GR) ligand-binding domain. Avg of 14 T2s each!
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Savor the small wins, because you can't sustain yourself on big Eureka moments only. You must find joy in a successful PCR reaction, in your plants having grown without being eaten by bugs, in cloning having worked etc etc
This week I was asked by an undergrad starting a PhD program this fall what my one piece of advice for her was.
What advice would you give?
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Huge congrats to
@maxplanckpress
colleague Jane
@ParkerLab_MPIPZ
, elected today to
@theNASciences
in recognition of her amazing work on
#plant
#immunity
!
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Please RT!
Do you have an interest in plant tissue culture and/or gene editing?
@DrPChronicles
in the lab is looking for a (paid) intern to help develop a protocol for DNA-free genome editing of
#cassava
protoplasts. Start from Feb 1, 2023, min. 2 months.
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Agree w
@EUCourtPress
that genome edited plants are as safe as transgenic plants, which have no proven risks different from conventionl plants. Decision otherwise completely ignores scientific facts, such as rampant background mutation rates
#GenomeEditing
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Translation: To get tenure, sacrifice the career prospects of multiple grad students and postdocs, if you must, to get that one big paper you can be proud of, instead of rewarding all students and postdocs with solid papers they can be proud of.
"To get tenure, aim to publish one big CNS paper from your lab, instead of multiple smaller papers"
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DIAMOND v2 is here! Check out this paper from
@bbuchfink
&
@HajkDrost
in our Department. Instead of "we blasted gazillions of genomes, which took several days" it will now be "we diamonded gazillions of genomes during the coffee break."
We hope our efforts to enable protein alignments at tree-of-life scale will inspire genomics research in the
@EBPgenome
era. An extraordinary effort with
@bbuchfink
& Klaus Reuter with fantastic support by
@PlantEvolution
,
@MPI_for_DB
&
@maxplanckpress
.
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Breaking news: EU Advocate General opinion -- genome edited organisms exempt from
#GMO
regulations (like X-ray or chemical mutants), as long as no intermediate transgenic step
#CRISPR
#GenomeEditing
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👏🏻👏🏻👏🏻
@EU_Commission
finds current
#GMO
laws “not fit for purpose” for new
#CRISPR
#GenomeEditing
technologies. Next steps: stakeholder consultation, hopefully soon followed by new legislation that is future proof.
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I have news for you: Many non-native English speakers have a much better command of the language than the average native speaker.
Reviewers: You can ask that the presentation be improved, but don't say "because the authors are non-native speakers". That's insulting.
“The English language ranks this manuscript among the top 5 worst manuscripts I have ever reviewed”
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Happy to see plants in
#NobelPrize2017
announcement. Would've been even happier w/ plant scientists among laureates
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Testing out a metaphor: if I want to enhance the performance of my old car again, do I go to a garage that knows loosening one particular screw will do the job, or should I rather ask somebody to randomly change a hundred screws? What’s more dangerous?
#mutagenesis
#GenomeEditing
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More summer reading: "How flower development genes were identified using forward genetic screens in
#Arabidopsis
thaliana" by David Smyth in Genetics
@GeneticsGSA
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I was so engrossed in the science all day long that I didn’t check email or Twitter and even had to steal this screenshot! Thank you to the organizers, all the amazing speakers and all of you who asked questions or just listened. This was the best birthday gift imaginable!
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... small typo: “how *animal* cells sense oxygen”
#plantblindnesss
The 2019 Nobel Prize in Physiology or Medicine has been awarded to Ratcliffe, Kaelin and Semenza for how cells sense and adapt to oxygen availability
@NobelPrize
#NobelPrize
#PremioNobel
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What a great read — perfect for a leisurely weekend. As expected impressive in its simplicity, clarity and beautiful prose. What I perhaps liked best is the equal billing given to 🦠 , 🍄, often 🌱🌿🌾🌼🥀, and 🐞🦋🦜🦒 including great apes.
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I’ve been incredibly lucky (another word for having had unearned privilege) to have had a series of amazing mentors. One of them was born 70 years ago on this day. Happy birthday, Elliot Meyerowitz!
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Running for city council for the only German party in favor of
#GMO
. To paraphrase the Tübingen Lord Mayor Boris Palmer: Shitstorm is inevitable.
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How to sample hundreds of seedlings for RNA-seq in 30 minutes in the time of Corona. Team WeigelWorld and friends from Bayer lab
@ZMBP_Tuebingen
@AS_in_Hohenheim
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Agree, agreed, agreed. I especially like:
“Know the literature better than your mentor.”
“Your mentor is losing neurons much faster than you.’
The last is sadly very true!
Advice to graduate students, beginning with "A PhD is not a picnic"
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What warms your heart: When you have an important appointment, and your lab sends you this:
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Dame Caroline Dean
@CarolineDeanLab
@JohnInnesCentre
to receive the Wolf Prize in Agriculture for her groundbreaking work on epigenetic memory. Congratulations, Caroline!
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The only way to save the American
#chestnut
is by
#GMO
. Greens & friends: What do you prefer – losing an iconic wild species because of ideology, or saving it with modern tech? And no, there is no alternative.
@sciencemagazine
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Must read: very accessible, yet nuanced
@FAO
booklet “Gene editing and agrifood systems”. Foreword by
@doudna_lab
, written by
@CaixiaGaoLab
@lidderpr
@jenniferkuzma0
@kevintzhao93
& others
#CRISPR
#GenomEditing
#GMO
@GreensEFA
@Die_Gruenen
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Congratulations, Dr. Ale Duque! Ale defended her thesis "Characterization of a Natural Arabidopsis thaliana –
Pseudomonas viridiflava Pathosystem" co-advised by
@KarasovTalia
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...and this is how oxygen sensing works in plants
2019 Medicine Laureates William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.
#NobelPrize
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1/2 ETI and PTI are not as different as you might think -- this collaborative study (not enough space to write out all Twitter handles!) shows how pathogen signals from both outside and inside the cell converge on the EDS1–PAD4–ADR1 node
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Congrats to
#plantsci
colleagues Alice Barkan,
@gregg_howe
, Elizabeth Ainsworth, Loren Rieseberg, Toby Kellogg
@TheKelloggLab
, Barbara Valent
@ValentLab
, Xiaofeng Cao & Spencer Barrett tto their election to
@theNASciences
#NAS157
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Wonderful surprise when I returned to the lab — everything set up for reenactment of the Helsinki ceremony, including top hat and sword! Checkout the beautiful
#Arabidopsis
🌱 engraving on the sword.
I’m not sure
@PlantEvolution
knew what he agreed to when accepting invitation to become an honorary doctor
@helsinkiuni
but he has preformed his duty with remarkable grace and enthusiasm!
@FilPromootio
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Recently on the bus, I chimed in regarding a conversation on COVID-19. Challenged as to my credentials, I said I’m Head of local Max Planck Institute. Was told I’m a liar. I wonder what image these folks had in their mind. (I’m a 58 year old white male.)
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What a brilliant idea! Engineer gRNA and
#Cas9
mRNA for long-distance mobility and then use grafting for one-shot generation of transgene-free plants!
#CRISPR
#GenomeEditing
#GMO
#GiveGenesAChance
CRISPR-edited plants using graft-mobile gene editing system !!! 😲
@NatureBiotech
▶️Heritable transgene-free genome editing in plants by grafting of wild-type shoots to transgenic donor rootstocks
📖
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What a great way to start the day: breakfast with your PhD advisor on a sunny September morning in the city where you got your PhD 31 years ago.
@MPI_for_DB
#Tuebingen
#T
übingen
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I'm Detlef, an
#actuallivingscientist
studying how plants adapt to their environment. I used to be a serious folk dancer.
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In this
@ThePlantCell
review,
@cbarragan91
& I review "Plant
#NLR
Diversity: The Known Unknowns of Pan-NLRomes"
Check out the mind boggling ways in which NLR clusters can change & directions for making sense of NLR diversity!
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How new genes are born:
#Arabidopsis
can produce thousands of
#lncRNAs
, but in most natural accessions, most of these lncRNAs are silenced.
#TEs
play a big role in this story. Super interesting work from
@kornienkoalexa
@magnusnordborg
#1001Genomes
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Congratulations, Dr.
@cbarragan91
, awarded a summa cum laude for her thesis "A DANGEROUS MIX: From Natural Variation to Genetic Incompatibilities in Arabidopsis thaliana and Arabidopsis arenosa"!
Next station:
@KamounLab
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Please RT: Two exciting PhD positions available: Mutational processes acting on transposable elements | New components of the (plant) immune system | Apply by 5 February.
(Check out how well our alumni & alumnae have done: )
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Please RT
#plantsci
#plantscijobs
#ecology
#evolution
#microbiome
Join us! 4 postdoc & 2 technical assistant positions, 6-year
@ERC_Research
effort with
@joybergelson
@EcogenLab
& us to "Understand and predict PATHOgen COMmunities (PATHOCOM)".
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#GMO
maize meta study: higher yield, lower toxins. Only non-target species affected by Bt maize: parasite of target herbivore
‘Impact of genetically engineered maize on agronomic, environmental & toxicological traits: meta-analysis of 21 years of data’
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Congratulations to three amazing plant scientists elected as International Members of
@theNASciences
:
• Regine Kahmann
@maxplanckpress
•
@gilesedoldroyd
@CropSciCentre
• Yi-Fang Tsai
@AcademiaSinica
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As far as I can tell, not even one of the undersigned has a background in genetics or molecular biology. Thus not even a single one seems to be qualified to evaluate the impact of genetic changes on organisms.
In other words, it would be like me weighing in on quantum physics.
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Can you please add a cartoon figure of what the cow looks like after journal submission and revision?
Don’t perish! A step by step guide to writing a scientific paper
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Why I love being a scientist: Sunday morning reading outside my field, a review on multispecific drugs in
@nature
by Ray Deshaies. Then stumbling across a paragraph on the “natural molecular glue” auxin!
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When the data do not support the conclusions but it is nevertheless published in a prominent place.
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Two WeigelWorld alumni, José
@JoseDinneny
& Moi
@MExpositoAlonso
recognized with
@ASPB
awards!
They not only do fantastic science, but are also setting examples in leadership, collegiality & how to lift up their team members. Congratulations!
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Mutation bias (in Arabidopsis thaliana) – is it real? [0/24|
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Not just one, but several postdoc positions in the lab of the one and only Jeff Dangl! Jeff is one of the most original plant biologists of our generation -- 10/10 recommend!
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Have you ever wondered how plants rejuvenate themselves, even though their germ cells are derived from adult somatic cells? Jian Gao and colleagues from Jia-Wei Wang's lab have the answer
#epigenetics
#miRNA
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Discovered this gem during lab cleaning: chart of my progress in chromosome walking with lambda phages in the Drosophila mastermind region. Chart uses Mb scale — covered 0.16 Mb from April 1985 to April 1986 😀
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Proof that scientists know what they are doing with
#GenomeEditing
, and that single gene mutations can be very useful |
@nature
editorial: "Super-tomato shows what plant scientists can do"
#CRISPR
@ebner_sha
@RenateKuenast
@peter_simone
@testbiotech
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1/2 At
@eLife
I advocate that a cool new phenomenon is vry much worth publishing, even if we don’t yet understand the “mechanism” behind it. If is something sufficiently interesting, that 1st pub in a highly visible place will hopefully greatly accelerate the quest for mechanism.
Been thinking about reviews that say a paper “lacks a mechanism”, as if identification of a new phenomenon isn’t important. The discovery of transposition lacked a mechanism, as did the discovery of splicing, or epigenetic silencing.
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Last preprint of the year: Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass led by
@Kersten_Sonja
@malacopa_genome
, collaboration with
@kjschmid
@christiandhuber
@YvesVandePeer
& more
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Congratulations
@irri
After rigorous biosafety assessment,
#GoldenRice
“has been found to be as safe as conventional rice" by the Philippine Department of Agriculture-Bureau of Plant Industry.
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Congratulations
@SandyKnapp
, botanist extraordinaire and the world’s foremost
#Solanum
hunter, for election to the American Academy of Arts and Sciences
@americanacad
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Wondering whether HiFi reads are as good as claimed, even when it comes to species with difficult-to-assemble centromeres such as Arabidopsis? (Yes, Arabidopsis centromeres more challenging than those from maize or rice!) 1/n
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@NobelPrize
Big day for
@maxplanckpress
@MPI_EVA_Leipzig
, ancient DNA as well as the visionaries of the Human Genome Project and the developers of
@illumina
massively parallel sequencing who made it all possible. Congratulations, Svante!
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Wissenschaftliche Fakten kann man sich nicht nach Belieben aussuchen. Wer Wissenschaft im Kampf gegen den Klimawandel ins Felde führt, kann nicht gleichzeitig faktenfrei gegen
#Gentechnik
#GMO
#CRISPR
argumentieren.
@Die_Gruenen
Gute PM von
@ebner_sha
zu neuer
#Gentechnik
: CRISPR/Cas ist genauso Gentechnik wie „herkömmliche“ Gentechnik und muss genauso geregelt, geprüft, gekennzeichnet werden. Alles andere wäre grobe Verbrauchertäuschung.
Gentechnikfreiheit statt Gentechnik ist Erfolgsmodell.
Stimmt!
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Congratulations,
@FEBS_Letters
! You just made utter fools of yourselves, celebrating 50 years with a speaker list that has 5% women. Yes, that's not a typo: 5%, not 50% women
FEBS = Federation of Elderly Balding Scientists?
…
#manpanels
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I’d add: and if you want to grow, you better surround yourself with peers who are smarter than you are!
No matter how smart you are, if you don’t surround yourself with smart peers, sooner or later you will wilt!!!
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#Transgenerational
inheritance of defense priming in Arabidopsis thaliana: apparently dependent on environment and experimenter
#epigenetics
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