Thrilled to share that our genome-edited wheat was just approved by Chinese regulators and granted a biosafety certificate! We edited four cuts, resulting in three gene knockouts and a ~403kb deletion(!) to generate disease resistance with enhanced yields https://t.co/L2VaKhZC5e

This genotype was first introduced by the amazing @CaixiaGaoLab in this 2022 @Nature publication Super exciting to see this scientific achievement be approved by regulators in ~2 years! https://t.co/hQWuqbDJpR

Congrats to all co-authors on this amazing study! Chenxiao Xue, Fengti Qiu, Yuxiang Wang, Boshu Li @kevintzhao93 and Kunling Chen!

We use our engineered enhanced plant prime editor ePPE to either (1) create de novo uORFs or (2) extend existing uORFs in order to down regulate gene expression to varying extents, which generates new germplasm with varying phenotypes

Our previous study in 2018 describes disrupting upstream open reading frames (uORFs) as a way to upregulate protein translation. In this 2023 study, we describe a complementary approach to downregulate protein translation https://t.co/X8qFGbvv9V

I'm excited to share with everyone our recent study on using precision genome editing technologies to tune gene expression in plants! 🌱🧬

Extremely humbled and honored to be part of the 2022 @ForbesUnder30 @ForbesAsia cohort! Huge thanks to @davidrliu for all the amazing training opportunities and to @CaixiaGaoLab for letting me work on exciting projects now! 🥳🧬🌱

Also new in @nature today is a paper that describes a wheat mutant that is resistant to powdery mildew without yield costs and the resisatnce allele of which can be rapidly introduced into elite wheat lines by precision genome editing https://t.co/e3du2jj7a3

Prime editing in plants is improved fivefold through molecular engineering by @CaixiaGaoLab

Views & News: "Wonder Wheat: A Disease-Resistant Crop Without Growth Tradeoff" -- @Demirer_GozdeS mulls over recent development of powdery mildew-resistant wheat via precision genome editing that does not have growth and yield penalties (@CaixiaGaoLab). https://t.co/uL6UnkU8Z7

I'm excited to share our newly engineered plant prime editor (ePPE) now online @NatureBiotech

Huge congratualtions to Yuan Zong, Yijing Liu, and Chenxiao Xue for leading this study! I'm excited to share this new tool with the global plant engineering community!

We combined our ePPE with two epegRNAs recently developed by @davidrliu to achieve even higher editing efficiencies across a variety of plant cells!

We discovered that the removal of the RNAseH domain in RTs and addition of a viral nucleocapsid protein improved prime editing efficiencies in plant cells

I'm excited to share our newly engineered plant prime editor (ePPE) now online @NatureBiotech

Thanks to @CrisprMedicine for highlighting our work and describing our future efforts! https://t.co/PSmjIb2BtQ

Thank you to @erikstokstad @ScienceMagazine for his amazing reporting on our work and the advancement of genome editing in crops in China https://t.co/KKEE6IJLmj

Huge congrats to Shengnan Li, Dexing Lin, Yunwei Zhang, Min Deng and all co-authors on this project!

I'm thrilled to share our 8-year effort @Nature describing disease resistant wheat without yield penalties! We use multiplex genome editing to create a 304-kilobase pair deletion, which revealed a novel relationship between disease resistance and growth.

Congrats @BrandeWulff for the fantastic study!