Jeremy Grenier MD PhD
@JGrenierMDPhD
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Pediatric Hematology-Oncology Fellow
Philadelphia, PA
Joined June 2022
This is a perfect sentiment - when you can't bear to see it anymore, that's how you know it's ready to go!
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Faculty position opening in our pediatric ‘Transplantation and Cellular Therapy’ Service @MSKCancerCenter Don’t hesitate to reach out to me for questions!!
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👇Fascinating observation. Raises important questions, including whether the @moderna_tx adjuvant vaccine study result in melanoma (Keynote-942) was attributable to *any* vaccine encoded epitopes. FYI: Neither this nor phase 3 (NCT05933577) has empty vector control. @FDA
🚨Our new paper is out today in Nature! We show that SARS-CoV-2 mRNA vaccines can sensitize tumors to immune checkpoint blockade (ICI) — revealing that clinically available RNA vaccines may act as potent immune modulators.
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How do mRNA vaccines help fight cancer? A @nature publication today tells the story, one with big implications, as reviewed here @MDAndersonNews
@StevenLin_MDPhD @adam_grippin
https://t.co/J0OvNP1Oc4
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In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxic effects. Full study results: https://t.co/CeklQvnuIj
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Tumor-on-chip models of CAR-T cell therapy @NatureBiotech
https://t.co/J6sc9yobAp
https://t.co/f33yyAxSEh
https://t.co/cNC60NnTBD
@CellStemCell
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#Cellcoast25 @MoffittNews expert presentation by @bshah describing the move to treat B-ALL with car t consolidation in frontline. Can we shorten therapy and eliminate the high relapse rate in adults by early CAR T? Looking v. promising.
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#genetherapy for #hemophilia can be life changing. Proud to offer this transformative treatment at @ChildrensPhila Gene therapy changed the life of a South Jersey man with hemophilia | PhillyVoice
phillyvoice.com
The novel treatment, partly developed by CHOP, eliminates the need for regular infusions while preventing the life-threatening bleeds caused by the condition.
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Our new, comprehensive review on CAR T cell persistence is officially published in @CellCellPress @trendscancer. Fantastic work from lead authors @kpmueller1 @JGrenierMDPhD. Link to the full article: https://t.co/4a0lsoqHtm
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In a national cohort of veterans, the 2024–2025 Covid-19 vaccine was linked to reduced risks of emergency department visits, hospitalizations, and deaths from Covid-19 @NEJM @zalaly
https://t.co/ZEMBuii04B
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We're thrilled to once again be ranked among the very best in the nation for Pediatric Cancer by @usnews!
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The description of regulatory T cells and connection to FoxP3 is a beautiful story for #Science and the #NobelPrize
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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Well done to @drclaireroddie and team for this amazing work. Many take home messages from this work -Lymphodepletion is essential for CAR-T to work -Repeat doses don't seem to work here, but more work is needed @HCC_UCLH
https://t.co/AbAKMEu2cC
ashpublications.org
Key PointsMatched allogeneic donor CD19 CAR-T therapy (CAR-DLI) is safe and effective for relapsed adult B-ALL but only after lymphodepletion.Repeat CAR-DL
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Huge shoutout to every NIH official grinding non-stop to support researchers and pushing through to meet that Sept 30 award deadline to ensure 100% of the funds are sent. You're the heroes keeping biomedical research alive. Unfortunately politicians are not as good as you are.
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Today is the last day of Childhood Cancer Awareness month. I haven't been able to find the words to do it justice--I'm not sure there are any. The world has told us pediatric cancer is "rare", in part to justify its low budget towards this research, but it's a lie.
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@MangusoLab @BrianC_Miller @MarcelaMaus @Nature @MGBResearchNews @broadinstitute Congrats Rob, beautiful study!
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This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease https://t.co/mZUmxYyII0
https://t.co/j3QTXcIEZM
https://t.co/VKWBGeE2aP
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@biorxivpreprint In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumor @jccarnevale @UCSF @GladstoneInst
https://t.co/AHukJHRety
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Long-term outcomes of genome-edited “universal” CAR19 T cells for relapsed/refractory B-ALL at a single pediatric center https://t.co/PwTHMJk8lQ
#clinicaltrialsandobservations #genetherapy #lymphoidneoplasia
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#ICYMI: Dr. Haley Newman receives @hopeonwheels Young Investigator Grant that will support research on risk predication models for T-cell malignancies. Learn more in this @6abc report: https://t.co/ZLpVf43GLv.
6abc.com
Children's Hospital of Philadelphia is a Hyundai Hope on Wheels grant recipient for their research to help identify which children with T-cell cancers are most likely to relapse.
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